Delving into the Latest Updates on Fenspiride Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Fenspiride, Fenspiride hydrochloride (USAN)

+ [5]

Target-

Action-

Mechanism-

Therapeutic Areas

Immune System DiseasesRespiratory Diseases

Active Indication

Asthma

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC15H20N2O2

InChIKeyFVNFBBAOMBJTST-UHFFFAOYSA-N

CAS Registry5053-06-5

View All Structures (2)

An open label, balanced, analyst blind, randomized, two treatment, two period, two sequence, single dose, crossover, bioequivalence study of Fenspiride hydrochloride extended release tablets 80 mg of Zuventus Healthcare Ltd. (A JV Company of Emcure Pharmaceuticals Ltd.) with PneumorelÂ® 80mg (Fenspiride hydrochloride tablets 80 mg) of Servier, France in normal, healthy, adult, human subjects under fasting condition.

Start Date13 Nov 2014

Sponsor / Collaborator

Zuventus Healthcare Ltd.

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100 Clinical Results associated with Fenspiride Hydrochloride

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100 Translational Medicine associated with Fenspiride Hydrochloride

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100 Patents (Medical) associated with Fenspiride Hydrochloride

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161

Literatures (Medical) associated with Fenspiride Hydrochloride

01 Feb 2025·Chromatographia

Development and Validation of Confirmatory Quantitative and Screening Methods for 63 Prohibited Substances in Horse Urine Using LC–MS/MS

Author: Goktas, Eylem Funda ; Kabil, Erol

Abstract: The number of potentially abused substances in horse racing is very large and it is not easy to analyze the full range.To facilitate the analyses of substances of abuse, a method has been developed for 63 substances in horse urine using liquid chromatog.-tandem mass spectrometry.The developed method has been validated according to the 2021/808/EC and AORC criteria.The horse urine samples were extracted after enzymic hydrolysis via a C8-BCX SPE cartridge with an automated SPE and analyzed by LC-MS/MS.According to the validation study results, the within-laboratory reproducibility CV was no more than 13.9% and the average recoveries ranged from 90.71 to 117.94% for repeatability and reproducibility.The decision limits (CCα) for quant. anal. and detection capabilities (CCβ) for qual. screening were close to the targeted limit for each substance.The results of the present study showed that the method was able to perform quant. analyses of 54 substances and screening analyses of 9 substances (total 63) in horse urine and that the results were valid and applicable.The validated method was successfully applied to five proficiency tests and three suspected samples.

19 Jul 2024·ACS Catalysis

Biocatalytic Construction of Spiro-Oxazolidinones via Halohydrin Dehalogenase-Catalyzed Ring Expansion of Spiro-Epoxides

Author: Wang, Yuan-Fei ; Jin, Xiao ; Wan, Nan-Wei ; Ma, Jin-Mei ; Miao, Run-Ping ; Chen, Yong-Zheng ; Wang, Hui-Hui

Spiro-oxazolidinones are highly valuable compounds in the fields of medicinal and organic chem.; however, the methods for synthesizing these compounds have not been well established.Herein, we present a biocatalytic methodol. for the construction of spiro-oxazolidinones through the halohydrin dehalogenase-catalyzed ring expansion of spiro-epoxides.By performing screening and protein engineering of halohydrin dehalogenases, both chiral and racemic spiro-oxazolidinones were synthesized in 24-47% yields (90-98% ee) and 69-98% yields, resp.The biocatalytic method was also applied to the efficient synthesis of the drug fenspiride at a high substrate concentration of 200 mM (44 g/L).In addition, a chemo-enzymic strategy was proposed to overcome the limitation of the maximum 50% yield inherent in the kinetic resolution process.Moreover, large-scale synthesis and representative transformations of the spiro-oxazolidinones were carried out to provide addnl. evidence of the practicality and applicability of the biocatalytic approach.

01 Apr 2024·Computers in Biology and Medicine

Exploring the anti-gout potential of sunflower receptacles alkaloids: A computational and pharmacological analysis

Article

Author: Wang, Kaiyu ; Li, Wannan ; He, Qizheng ; Liu, Kaifeng ; Han, Weiwei ; Fu, Xueqi ; Cui, Huizi

Gout, a painful condition marked by elevated uric acid levels often linked to the diet's high purine and alcohol content, finds a potential treatment target in xanthine oxidase (XO), a crucial enzyme for uric acid production. This study explores the therapeutic properties of alkaloids extracted from sunflower (Helianthus annuus L.) receptacles against gout. By leveraging computational chemistry and introducing a novel R-based clustering algorithm, "TriDimensional Hierarchical Fingerprint Clustering with Tanimoto Representative Selection (3DHFC-TRS)," we assessed 231 alkaloid molecules from sunflower receptacles. Our clustering analysis pinpointed six alkaloids with significant gout-targeting potential, particularly emphasizing the fifth cluster's XO inhibition capabilities. Through molecular docking and the BatchDTA prediction model, we identified three top compounds-2-naphthylalanine, medroxalol, and fenspiride-with the highest XO affinity. Further molecular dynamics simulations assessed their enzyme active site interactions and binding free energies, employing MM-PBSA calculations. This investigation not only highlights the discovery of promising compounds within sunflower receptacle alkaloids via LC-MS but also introduces medroxalol as a novel gout treatment candidate, showcasing the synergy of computational techniques and LC-MS in drug discovery.

1

News (Medical) associated with Fenspiride Hydrochloride

18 Feb 2019

·www.bioportfolio.com

UK Industry Skeptical Of Govt’s No-Deal Brexit Filing Expectations

The BioIndustry Association’s latest Brexit webinar looked at issues such as companies’ drug filing strategies in a no-deal scenario as... Related Stories Heart Rhythm Concerns Prompt EU-Wide Suspension For Fenspiride Cough Medicines Australia Considers Identifying Drugs Filed For Approval FDA Launches Pilot To Gain Practical Experience With 'Established Conditions' In Quality Assessments

100 Deals associated with Fenspiride Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D04163	Fenspiride Hydrochloride	R03DX03 R03BX01	DB08979

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Asthma	-	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ERS2018	Not Applicable	Pulmonary Disease, Chronic Obstructive serum TNF-α \| IL-1β \| IL-8	39	Fenspiride 80 mg	(srsgqtzsme) = mlnyigfyzh yritkqbjsb (kfsdimkibm ) View more	Positive	15 Sep 2018
				Beta2-agonists	(srsgqtzsme) = dulkhnroov yritkqbjsb (kfsdimkibm ) View more
ERS2017	Not Applicable	Pulmonary Disease, Chronic Obstructive	42	Fenspiride 80 mg	(goljxwrbsw) = epyztzybct fveolfocmh (vvpeanzaqf ) View more	Positive	01 Sep 2017
				Bronchodilators (Beta2-agonists)	(goljxwrbsw) = gzmkocnqpx fveolfocmh (vvpeanzaqf ) View more
EULAR2017	Not Applicable	-	18	Fenspiride (15 mg/kg)	njeovyufar(tjlvnsvhkv) = usvjlywkmv exohvszllm (gbzsxdtecg ) View more	Positive	14 Jun 2017
				Saline solution (4ml/kg)	njeovyufar(tjlvnsvhkv) = nqzmbmyzqr exohvszllm (gbzsxdtecg ) View more
ERS2012	Not Applicable	Pulmonary Disease, Chronic Obstructive	-	Fenspiride 15 mg/kg	axyfayrhup(snxtyboyoy) = frvsaxbltp wuvxovmkym (hykerpdegw )	-	01 Sep 2012