Delving into the Latest Updates on Ornidazole with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Orinidazole, Ornidazole (USAN/INN)

+ [7]

Target-

Mechanism-

Therapeutic Areas

Infectious DiseasesDigestive System Disorders

Active Indication

AmebiasisAnaerobic bacterial infectionGiardiasis+ [1]

Inactive Indication

Dysentery, AmebicLiver Abscess, AmebicUrogenital infection by Trichomonas vaginalis

Originator Organization

Huadong Medicine (xi'an) Bodyguard Pharmaceutical Co., Ltd.

Active Organization

Huadong Medicine (xi'an) Bodyguard Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (01 Jan 2001),

AmebiasisAnaerobic bacterial infectionGiardiasis+ [1]

Regulation-

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Structure

Molecular FormulaC7H10ClN3O3

InChIKeyIPWKIXLWTCNBKN-UHFFFAOYSA-N

CAS Registry16773-42-5

The improper utilization of nitrobenzene (NB) and ornidazole (ORN) has resulted in irreversible effects on the environment. By combining experimental investigation, density functional theory (DFT) calculations, and machine learning, an effective green strategy for detecting NB and ORN in aqueous solutions can be developed. In this study, a one-dimensional Cd-based coordination polymer (Cd-HCIA-3) was designed and synthesized using 5-((4-carboxybenzyl)oxy)isophthalic acid and rigid 2,2'-bipyridine under solvothermal reaction conditions. Cd-HCIA-3 exhibits excellent fluorescence properties and stability in aqueous solutions. DFT calculations were performed to predict the fluorescence sensing performance of Cd-HCIA-3, revealing that photoinduced electron transfer is the key mechanism for inducing fluorescence quenching in the presence of NB and ORN, with weak molecular interactions promoting electron transfer. Fluorescence sensing experiments were conducted to verify the DFT results, showing that Cd-HCIA-3 can selectively detect NB and ORN in aqueous solutions with limits of detection of 7.22 × 10^-8 and 1.31 × 10^-7 mol/L, respectively. This study's findings provide valuable insights into the design and synthesis of fluorescent coordination polymers for target analytes.

19 Sep 2024·Analytical and bioanalytical chemistry

Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products.

Article

Author: Liu, QingYi ; Zhou, Jian ; Jiang, Bin ; Li, FuKai ; Yang, MengRui ; Zhang, LiYuan ; Wang, Min

It is of significant importance to public health that reliable monitoring of nitroimidazoles be conducted, while certified reference materials (CRMs) are essential for accurate and reliable detection. A project has been initiated with the objective of developing nitroimidazole purity CRMs to ensure that results from nationwide monitoring laboratories for nitroimidazoles in antibiotic residues can be compared and traced. The candidates were successively characterized in terms of their structure by means of infrared (IR) spectroscopy and mass spectrometry (MS). The mass balance (MB) method and the quantitative nuclear magnetic resonance (qNMR) method were utilized to determine the purity of nitroimidazoles with remarkable accuracy. Furthermore, a methodical investigation was conducted on homogeneity, stability, and uncertainty. Six nitroimidazole purity CRMs, including tinidazole (GBW09252), secnidazole (GBW09286), ronidazole (GBW09288), metronidazole (GBW(E)090755), dimetridazole (GBW(E)090819), and ornidazole (GBW(E)090820), were finally manufactured following authorization from China's State Administration for Market Regulation (SAMR). By using these CRMs, it is possible to improve the traceability, accuracy, and comparability of nitroimidazole measurements in a range of agricultural products, protecting public health.

15 Jul 2024·ACS Applied Bio Materials

ε-Poly-l-lysine: A Naturally Occurring Biodegradable Polypeptide for Selective Detection of 5-Nitroimidazole Antibiotics in Animal Products and Living Cells via Fluorescence

Article

Author: Porel, Mintu ; Jose, Anna ; Sahadevan, Revathy ; Sadhukhan, Sushabhan ; Vijayan, Vishnu N ; Kannan, Karthika

The 5-nitroimidazole (5-NI) class of antibiotics, such as metronidazole, ornidazole, secnidazole, and tinidazole, are widely used to prevent bacterial infection in humans and livestock industries. However, their overuse contaminates the farmed animal products and water bodies. Hence, a selective, sensitive, and cost-effective method to detect 5-NI antibiotics is the need of the hour. Herein, we report a rapid, inexpensive, and efficient sensing system to detect 5-NI drugs using an as-prepared solution of ε-poly-l-lysine (ε-PL), a naturally occurring and biodegradable homopolypeptide that has an intrinsic fluorescence via clustering-triggered emission. The low nanomolar detection limit (3.25-3.97 nM) for the aforementioned representative 5-NI drugs highlights the sensitivity of the system, outperforming most of the reported sensors alike. The resulting fluorescence quenching was found to be static in nature. Importantly, excellent recovery (100.26-104.41%) was obtained for all real samples and animal products tested. Visual detection was demonstrated by using paper strips and silica gel for practical applications. Furthermore, ε-PL could detect 5-NI antibiotics in living 3T3-L1 mouse fibroblast cells via cellular imaging. Taken together, the present work demonstrates the detection of 5-NI antibiotics using a biocompatible natural polypeptide, ε-PL, and represents a simple and inexpensive analytical tool for practical application.

100 Deals associated with Ornidazole

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External Link

KEGG	Wiki	ATC	Drug Bank
D05274	Ornidazole	P01AB03 J01XD03 G01AF06	DB13026

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Amebiasis	CN	Huadong Medicine (xi'an) Bodyguard Pharmaceutical Co., Ltd.	01 Jan 2001
Anaerobic bacterial infection	CN	Huadong Medicine (xi'an) Bodyguard Pharmaceutical Co., Ltd.	01 Jan 2001
Giardiasis	CN	Huadong Medicine (xi'an) Bodyguard Pharmaceutical Co., Ltd.	01 Jan 2001
Trichomonas Infections	CN	Huadong Medicine (xi'an) Bodyguard Pharmaceutical Co., Ltd.	01 Jan 2001

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Anaerobic bacterial infection	Discovery	CN	-	10 Oct 2013
Dysentery, Amebic	Discovery	CN	-	10 Oct 2013
Giardiasis	Discovery	CN	-	10 Oct 2013
Liver Abscess, Amebic	Discovery	CN	-	10 Oct 2013
Urogenital infection by Trichomonas vaginalis	Discovery	CN	-	10 Oct 2013