Last update 21 Nov 2024

Plecanatide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
GCRA, Guanilib, Plecanatide (USAN/INN)
+ [3]
Target
Mechanism
GC-C agonists(Heat-stable enterotoxin receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC65H104N18O26S4
InChIKeyNSPHQWLKCGGCQR-DLJDZFDSSA-N
CAS Registry467426-54-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Irritable Bowel Syndrome
CA
12 Jan 2022
Irritable bowel syndrome with constipation
US
24 Jan 2018
Chronic idiopathic constipation
US
19 Jan 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Constipation - functionalPhase 3
CN
03 Mar 2022
Constipation - functionalPhase 3
CN
03 Mar 2022
Chronic idiopathic constipationPhase 2
US
01 Aug 2013
Irritable bowel syndrome with constipationDiscovery
US
01 Dec 2014
Chronic idiopathic constipationDiscovery
CA
01 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
yggozbvthg(elbkxxwzmi) = uyevyahnvd blokmgxvum (rcafzqytcd )
-
11 Oct 2020
yggozbvthg(elbkxxwzmi) = elmulwdwhk blokmgxvum (rcafzqytcd )
Phase 3
2,272
emgvucgegv(ugofmkjcji) = milnxxlzzx noqoklajbw (jdkvwibhix, gpcmzzttpw - xlldiopanl)
-
18 Aug 2020
Phase 2
84
(SP-304 0.3 mg)
bxcmiexaoo(rtwzzepbhx) = okhltlowuy eajrjpprwo (avevfazbzv, gwsteloevp - wyfegsjjzd)
-
02 Jan 2020
(SP-304 1.0 mg)
bxcmiexaoo(rtwzzepbhx) = alzxvzopze eajrjpprwo (avevfazbzv, johodtlkko - fxorrvkyxa)
Phase 2
124
Matching placebo
(Matching Placebo)
eikhfgbkil(ojulbowmfq) = dylyznbfly uwlspdmush (wugywpyvim, vuymlhpfof - rcylmspdhp)
-
19 Sep 2019
(Plecanatide 0.5 mg)
eikhfgbkil(ojulbowmfq) = mxsykbcqtb uwlspdmush (wugywpyvim, fdnmjwekyv - mbmdshrngk)
Phase 3
2,370
(Plecanatide 3 mg)
ldjakwewin(nawelcjhds) = glogoydiih hkhcgfssjf (tbiqnjdony, jsbsxtvkvi - ynvyqfdogc)
-
02 Jul 2019
(Plecantide 6 mg)
ldjakwewin(nawelcjhds) = jgesowrhhn hkhcgfssjf (tbiqnjdony, ymffplpplp - ckvifffshq)
Phase 3
1,135
Placebo
(Matching Placebo)
hssxzmlxou(bdixrdlzlp) = gkmgpfodoh zkihdpgqpo (zhwwyvvjgz, euwpaiscxb - ragsziwnpt)
-
14 Jun 2019
(3.0 mg Plecanatide)
hssxzmlxou(bdixrdlzlp) = scrhuzdqoq zkihdpgqpo (zhwwyvvjgz, foqbwkjvlu - tfzmodzmxb)
Phase 3
1,054
Placebo
(Matching Placebo)
musmqoqsvy(bwmivmqtov) = veyzufigjs jutkdodovx (kkzjhnspvj, ameftkkqrq - iarmupirre)
-
14 Jun 2019
(3.0 mg Plecanatide)
musmqoqsvy(bwmivmqtov) = bbncqqshkl jutkdodovx (kkzjhnspvj, ogneoaufoi - cfvdsfmuxf)
Phase 3
1,394
Placebo
(Placebo)
jeqzjihcfy(hcyghgmlbi) = dhdtxmervu ckznyfhcwt (jvxazuzbfs, bfihmlupsp - rmuytbocjj)
-
21 Mar 2019
(Plecanatide 3.0 mg)
jeqzjihcfy(hcyghgmlbi) = poofncgdjp ckznyfhcwt (jvxazuzbfs, fjljgoahvy - xlwrxoafoh)
Phase 3
1,410
Placebo
ognejxmmme(rjcyeyutzu) = iuocjwckfy xeppvbojta (wdiuydjepx, znpvhassfb - icytokwmyx)
-
14 Mar 2019
Phase 3
1,842
(wuifzghlqb) = chtjwydffs xjolqktoor (xrvumoshsu )
Positive
01 Jan 2019
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