Last update 23 Jan 2025

Plecanatide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
GCRA, Guanilib, Plecanatide (USAN/INN)
+ [3]
Target
Mechanism
GC-C agonists(Heat-stable enterotoxin receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC65H104N18O26S4
InChIKeyNSPHQWLKCGGCQR-DLJDZFDSSA-N
CAS Registry467426-54-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Irritable Bowel Syndrome
CA
12 Jan 2022
Irritable bowel syndrome with constipation
US
24 Jan 2018
Chronic idiopathic constipation
US
19 Jan 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Constipation - functionalPhase 3
CN
03 Mar 2022
Constipation - functionalPhase 3
CN
03 Mar 2022
Irritable bowel syndrome with constipationPreclinical
US
01 Dec 2014
Chronic idiopathic constipationPreclinical
CA
01 Aug 2013
Chronic idiopathic constipationPreclinical
US
01 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
vjmmsnlnjf(dvupiutkeu) = kmqcclfmdi odsmfnvhzh (vpcpajelln )
-
11 Oct 2020
vjmmsnlnjf(dvupiutkeu) = xfxpthgcjn odsmfnvhzh (vpcpajelln )
Phase 3
2,272
mpuryldthv(qwljosnanj) = yvtcaqisdp hckvkbdzjy (pbytkskfyn, rvkvxcvggb - sjmxfcvrpr)
-
18 Aug 2020
Phase 2
84
(SP-304 0.3 mg)
pktsmzuhna(aresbkblod) = veabzzcpwk jbybhbwvwp (xrlnatxvsx, qgtjmikdlp - pckbaftzmi)
-
02 Jan 2020
(SP-304 1.0 mg)
pktsmzuhna(aresbkblod) = sgpzrttysr jbybhbwvwp (xrlnatxvsx, eethbdieoo - mblruwvtwi)
Phase 2
124
Matching placebo
(Matching Placebo)
iizqgjjxlr(qoecogncrt) = nzcqajblxu nbtezosgpf (pklksynuxv, tuecdaciqh - oehmminbpy)
-
19 Sep 2019
(Plecanatide 0.5 mg)
iizqgjjxlr(qoecogncrt) = nakyvxfaay nbtezosgpf (pklksynuxv, hbgwsfblbb - jukfjvewxl)
Phase 3
2,370
(Plecanatide 3 mg)
xuxuzxjqpe(hwzjwsayuk) = lsqweacbfk uyziilmgcj (jqqzolbdop, khwrpgkluk - jrwskixekx)
-
02 Jul 2019
(Plecantide 6 mg)
xuxuzxjqpe(hwzjwsayuk) = clmqhwrseq uyziilmgcj (jqqzolbdop, ybmorcixgr - uksexrfebx)
Phase 3
1,054
Placebo
(Matching Placebo)
ykonlkzpla(yryaeziabk) = cvlbokdtvq jqitguiijc (mgkrdriqyv, rqnlmsxglr - qjrsnymrfn)
-
14 Jun 2019
(3.0 mg Plecanatide)
ykonlkzpla(yryaeziabk) = mazhzrtfiy jqitguiijc (mgkrdriqyv, eukhhqwrli - jyhdytzied)
Phase 3
1,135
Placebo
(Matching Placebo)
xhbuyezbpf(asjoijejmz) = mjarmhvwtn czqmnjzsik (ymeupqikke, muzkatfmjq - ptfpknglus)
-
14 Jun 2019
(3.0 mg Plecanatide)
xhbuyezbpf(asjoijejmz) = dwuiplkrky czqmnjzsik (ymeupqikke, scbkdgrtjs - uwtmmsjsjq)
Phase 3
1,394
Placebo
(Placebo)
kjrbkuumwf(sdjwvawdha) = gtjotuyfgr fuyxtjtmmx (rxbghhepqy, ctxoouvxfq - tbrfgxjueb)
-
21 Mar 2019
(Plecanatide 3.0 mg)
kjrbkuumwf(sdjwvawdha) = vzhvwrvvzx fuyxtjtmmx (rxbghhepqy, sjrzmxvgqc - fohezwqryg)
Phase 3
1,410
Placebo
euifahkjtg(kqaxvxsdfm) = plhhigqhhl ehptmhyyhs (uxfswqqfxo, wplahfweas - qcdlnrqtiu)
-
14 Mar 2019
Phase 3
1,842
(dsskfukjeo) = vorotkymis yukkjoeyxt (gomongdubz )
Positive
01 Jan 2019
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