Delving into the Latest Updates on ZX-2401 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-amino-8-(beta-D-ribofuranosyl) imidazo [1,2-a]-s-triazine-4-one

Target-

Action-

Mechanism-

Therapeutic Areas

NeoplasmsImmune System DiseasesInfectious Diseases+ [3]

Active Indication-

Inactive Indication

DengueEnzootic Bovine LeukosisWest Nile Fever+ [1]

Originator Organization

Zymetx, Inc.

Active Organization-

Inactive Organization

Zymetx, Inc.

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

The viruses in the Flaviviridae family have been associated with human and animal diseases. In this report, we demonstrate that compound 2-amino-8-(beta-D-ribofuranosyl) imidazo [1,2-a]-s-triazine-4-one (ZX-2401) was capable of inhibiting the production in culture of at least five members of the Flaviviridae family with minimal cytotoxicity. This compound inhibited yellow fever virus, dengue virus, bovine viral diarrhea virus, banzi virus and West Nile virus with EC50 of 10, 10, 5, 5 and 3 microg/ml, respectively, and the CC50 in these experiments were greater than 1000 microg/ml. The activity of ZX-2401 is comparable to or better than the control drugs in these studies and was not affected by MOI variation. In addition, ZX-2401 inhibited HCV replication in a dose response fashion in the replicon assay system. Furthermore, ZX-2401 exhibited a synergistic antiviral activity in combination with IFN in tissue culture. The data described herein suggest that ZX-2401 is a broad-spectrum inhibitor of the RNA viruses, which has merit for development of treatments for the emerging infections caused by the viruses in the Flaviviridae family.

100 Deals associated with ZX-2401

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Dengue	Preclinical	United States	Zymetx, Inc.	30 Nov 2005
Enzootic Bovine Leukosis	Preclinical	United States	Zymetx, Inc.	30 Nov 2005
West Nile Fever	Preclinical	United States	Zymetx, Inc.	30 Nov 2005
Yellow Fever	Preclinical	United States	Zymetx, Inc.	30 Nov 2005