Osteoporosis is a common senile disease with a high incidence. The Chinese medicine differentiation treatment has small side effects and can be taken for a long time, which has certain advantages. This project adopts the experience of the person in charge of the project-Xulin Jiangu Granules and clinically collects patients with postmenopausal osteoporosis (kidney deficiency and blood stasis syndrome).

Start Date01 Sep 2019

Sponsor / Collaborator

Fujian University of Traditional Chinese Medicine

100 Clinical Results associated with Xulin Jiangu granules

100 Translational Medicine associated with Xulin Jiangu granules

100 Patents (Medical) associated with Xulin Jiangu granules

Literatures (Medical) associated with Xulin Jiangu granules

01 Jun 2022·Biomedicine & PharmacotherapyQ2 · MEDICINE

Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis

Q2 · MEDICINE

Article

Author: Yang, Juan ; Lin, Yanping ; Sun, Pan ; Zhou, Fen ; Huang, Yunmei ; Zhang, Chutian ; Zeng, Jianwei

BACKGROUNDPostmenopausal osteoporosis (PMOP) is a common disease that has decreased bone strength as its main symptom after menopause. Effective treatment for PMOP remains lacking, but traditional Chinese medicine has some advantages in delaying bone loss. Jiangu granule is a traditional Chinese medicine prescription commonly used to treat PMOP. Previous studies have demonstrated its efficacy, but the mechanism of action remains uncharacterized.PURPOSEThis study aims to observe and discuss the mechanism of Jiangu granule to ameliorate bone loss in OVX rats by regulating the gut microbiota (GM)-short-chain fatty acids (SCFAs)- Treg/Th17 axis.METHODSFemale SD rats were divided into the sham operation (S), Jiangu granule (J), and model group (M). Bilateral ovaries were surgically removed from the rats in the J and M groups. After 6 and 12 weeks, rats were sacrificed, and femur, tibia, vertebrae, serum, spleen, colon, and feces samples were collected. We detected the strength of bones, gut microbiota structure, and SCFAs in feces, the Treg and Th17 cell levels in the spleen, and cytokine levels in the serum.RESULTJiangu granule restored the abundance of gut microbiota, increased the content of SCFAs, reduced the permeability of colon epithelium, increased the proportion of Treg cells in the spleen, changed the osteoimmunomodulation-related cytokines, effectively prevented bone loss, and enhanced bone strength.CONCLUSIONJiangu granule can effectively improve bone loss in OVX rats, possibly by regulating the "GM-SCFAs-Treg/Th17″ axis.

01 May 2002·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Study on preventive effect of jiangu granule on osteoporosis in ovariectomized rats].

Article

Author: Ma, Jian-hua ; Lin, Yan-ping ; Feng, Er-you

OBJECTIVETo investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I.METHODSOsteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also.RESULTSJGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level.CONCLUSIONJGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.

Frontiers in Pharmacology

4D label-free quantitative proteomics analysis to screen potential drug targets of Jiangu Granules treatment for postmenopausal osteoporotic rats

Article

Author: Zheng, Minlin ; Lin, Haiming ; Zhang, Wei ; You, Zexing ; Xu, Yashi ; Li, Chaoxiong ; Liu, Zhentao

Background: Postmenopausal osteoporosis (PMOP) is a disease with a high prevalence in postmenopausal women and is characterized by an imbalance in bone metabolism, reduced bone mass, and increased risk of fracture due to estrogen deficiency. Jiangu granules (JG) is a compound prescription used in traditional Chinese medicine to treat PMOP. However, its definitive mechanism in PMOP is unclear. This study used a 4D label-free quantitative proteomics method to explore the potential therapeutic mechanism of JG in an ovariectomy (OVX) rats’ model.Materials and methods: A rat model of PMOP was established by removing the ovaries bilaterally. Nine 3-month-old specific-pathogen-free female SD rats. The nine rats were randomly divided into 3 groups (n = 3 in each group): the sham-operated group (J), the ovariectomy group (NC), and the JG treatment (ZY) group. Proteins extracted from the bone tissue of the lumbar spine (L3, L4) of three groups of rats were analyzed by 4D label-free quantitative proteomics, and proteins differentially expressed after JG treatment and proteins differentially expressed after de-ovulation were intersected to identify proteins associated with the mechanism of PMOP by JG treatment.Result: There were 104 up-regulated and 153 down-regulated differentially expressed proteins (DEPs) in the J group vs. NC group, 107 up-regulated and 113 down-regulated DEPs in the J group vs. ZY group, and 15 up-regulated and 32 down-regulated DEPs in the NC group vs. ZY group. Six potential target proteins for JG regulation of osteoblast differentiation in OVX rats were identified by taking intersections of differential proteins in the J group vs. NC group and NC group vs. ZY group.Conclusion: JG may exert therapeutic effects by modulating the expression levels of target proteins associated with osteoblast differentiation to enhance osteoblast differentiation in OVX rats. These results further uncovered the target proteins and specific mechanisms of JG in treating PMOP, providing an experimental basis for the clinical application of JG in treating PMOP.

100 Deals associated with Xulin Jiangu granules

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Blood Stasis	Phase 1	CN	Fujian University of Traditional Chinese Medicine	01 Sep 2019
Kidney Diseases	Phase 1	CN	Fujian University of Traditional Chinese Medicine	01 Sep 2019
Osteoporosis, Postmenopausal	Phase 1	CN	Fujian University of Traditional Chinese Medicine	01 Sep 2019

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

Xulin Jiangu granules

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation