Delving into the Latest Updates on Fujian University of Traditional Chinese Medicine with Synapse

Overview

Tags

Hemic and Lymphatic Diseases

Neoplasms

Immune System Diseases

Proteolysis-targeting chimeras (PROTAC)

Herbal medicine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Hemic and Lymphatic Diseases	9
Neoplasms	9
Immune System Diseases	9

Top 5 Drug Type	Count

Proteolysis-targeting chimeras (PROTAC)	9
Herbal medicine	1

Top 5 Target	Count

EZH2(Histone-lysine N-methyltransferase EZH2)	8
EED x EZH2 x SUZ12	1

Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity. The structural damage of the cortical swallowing network and abnormal activation of brain areas related to swallowing in post-stroke dysphagia affect swallowing activity. The recovery of dysphagia after stroke is related to the compensation of swallowing network in the contralateral hemisphere and different connectivity patterns of diseased brain areas, and the integrity of cortical swallowing network connectivity affects the sequence of oral swallowing activities. However, it is not clear how the functional connectivity patterns and interactions of brain regions of the cortical swallowing network related to oral swallowing activity change in patients with oral dysphagia after stroke.

Start Date20 Aug 2024

Sponsor / Collaborator

Fujian University of Traditional Chinese Medicine

ChiCTR2400087100

/ SuspendedNot ApplicableIIT

Effectiveness of Tai Ji Quan Training for psychological health among stressed graduate students: A randomized controlled trial

Start Date01 Aug 2024

Sponsor / Collaborator

Fujian University of Traditional Chinese Medicine

100 Clinical Results associated with Fujian University of Traditional Chinese Medicine

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0 Patents (Medical) associated with Fujian University of Traditional Chinese Medicine

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4,920

Literatures (Medical) associated with Fujian University of Traditional Chinese Medicine

01 Apr 2025·Talanta

Integration of feature-based molecular networking and high-definition data-dependent acquisition for the comprehensive multicomponent characterization of Honghua Xiaoyao Tablet

Article

Author: Ma, Siyi ; Zeng, Huawu ; Ye, Ji ; Zhang, Weidong ; Wu, Shiyu ; Zhang, Shiyu ; Zhu, Renwen ; Zhang, Yuhao

Systematically identifying the chemical constituents in complex matrices is a challenge due to the inherent characteristics of compounds. The combination of liquid chromatography-tandem mass spectrometry (LC-MS) and classical molecular networking (CLMN) is a powerful technology for annotating small molecules. However, the low coverage from inappropriate acquisition modes and the inseparability of isomeric compound nodes still hinders the comprehensive metabolite characterization. A novel strategy that integrated high-definition data-dependent acquisition (HDDDA) from traveling-wave ion mobility mass spectrometry (TWIMS) and feature-based molecular networking (FBMN) was developed to improve chemical component characterization and enhance isomeric component discernment. The data-dependent acquisition (DDA) and HDDDA, were effectively and visually evaluated by CLMN and FBMN via the number of nodes, clustered nodes and clusters. Moreover, the efficiency of the three strategies was validated. The results strongly demonstrated that the HDDDA-FBMN strategy improves MS coverage and offers significant advantages for isomer identification. With the assistance of the UNIFI platform, the developed strategy was successfully applied to systematically investigate the chemical profile of Honghua Xiaoyao Tablet (HHXYT), a traditional folk empirical prescription for treating various gynecological diseases. 184 compounds were unambiguously identified or tentatively characterized, including 12 pairs of isomers, and two unreported compounds. In conclusion, this hybrid approach achieves dimensionally enhanced MS data acquisition and visual recognition of isomeric compounds, accelerating the structural characterization in complex systems. We anticipate that HDDDA-FBMN strategies will be a flexible and versatile tool for the chemical components in a complex system of TCMs.

01 Apr 2025·Food Chemistry

Highly sensitive aggregation-induced electrochemiluminescence sensor for cadmium detection in Ganoderma lucidum

Article

Author: Gao, Hang ; Xu, Zhi-Hong ; Huang, Ze-Hao ; Xu, Wei ; Weng, Xin ; Xu, Wen ; Lin, Yu ; Wang, Sha-Sha

Cadmium (Cd) pollution poses a major threat to food safety. Sensitive detection of Cd²⁺ is of great significance for the life health. Herein, an aggregation-induced electrochemiluminescence (AIECL) sensor based on polymer dots (Pdots) is designed for Cd²⁺ detection. Through linkage of Cd²⁺ aptamer containing black hole quencher (BHQ) with Pdots, a signal "off" probe was achieved. In the presence of Cd²⁺, the BHQ moiety is released from Pdots and the ECL signal of Pdots is recovery. Such sensor exhibits excellent detection capability for Cd²⁺, with low detection limit of 0.006 ppb. More importantly, the sensor is applied for the quantitative analysis of Cd²⁺ in Ganoderma lucidum, and the results coincide well with the golden standard of ICP-MS. This study presents a facile and reliable methodology for the sensitive detection of cadmium, and demonstrates its potentials applying in food safety and environmental monitoring.

01 Mar 2025·Travel Medicine and Infectious Disease

Association between influenza vaccination and prognosis in patients with ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials

Review

Author: Yu, Peng ; Li, Lin ; Liu, Fuwei ; Huang, Jinyi ; Wu, Yifan ; Liu, Xiao ; Zhang, Deju ; Fang, Changchang ; Fan, Ruoyun ; Zhao, Huilei ; Zhang, Jiayu

BACKGROUNDThere is substantial epidemiological evidence demonstrating that influenza contributes to cardiovascular events in patients who already have cardiovascular diseases. However, the efficacy of influenza vaccination on the prognosis of patients with ischemic heart disease (IHD) is unclear.METHODSWe conducted a systematic search for eligible randomized controlled trials (RCTs) in PubMed, Cochrane, and Embase on September 13, 2024, to investigate the effects of the influenza vaccine on the prognosis of patients with IHD. The effect sizes were combined using random-effects models, and Trial Sequential Analysis (TSA) was used to assess the reliability and validity of the results.RESULTSFive RCTs with a total of 5659 patients (median age ranging from 57.1 to 66 years, 67.8% male) with IHD were included. The use of influenza vaccine reduced the risk of major adverse cardiovascular events (risk ratio [RR] = 0.67, 95% confidence interval [CI] 0.52-0.87, number-needed-to-treat [NNT] of 37, high certainty), cardiovascular death (RR = 0.55, 95% CI 0.35-0.87, moderate certainty), all-cause mortality (RR = 0.58, 95% CI 0.40-0.84, high certainty) and myocardial infarction (MI) (RR = 0.66, 95% CI 0.46-0.93, high certainty) in patients with IHD compared with control. The analysis revealed no significant benefit regarding hospitalization for heart failure (HF) (RR = 0.91, 95% CI 0.21-3.99, moderate certainty) and revascularization (RR = 0.59, 95% CI 0.10-3.45, moderate certainty). The NNT to avoid 1 event was 37 for major adverse cardiovascular events, 56 for cardiovascular death, 67 for MI, and 41 for all-cause death. TSA showed that the benefit of influenza vaccine in reducing MACE was conclusive, no more trials were necessary.CONCLUSIONThis study suggests high level of evidence that the use of influenza vaccine may reduce the risk of major adverse cardiovascular events in patients with IHD.

100 Deals associated with Fujian University of Traditional Chinese Medicine

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100 Translational Medicine associated with Fujian University of Traditional Chinese Medicine

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Pipeline

Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

9

1

Phase 2 Clinical

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Qingda Granules	Hypertension More	Phase 2
E-5CH2-V2 ( EZH2 )	Lymphoma More	Preclinical
E-5CH2-V1 ( EZH2 )	Lymphoma More	Preclinical
E-2P-MDM2 ( EZH2 )	Lymphoma More	Preclinical
E-CH2-V1 ( EZH2 )	Lymphoma More	Preclinical