MK-5286

Chromene derivatives were designed and their pharmacophores were evaluated for the determination of their activity as antiinflammatory agents against 5-lipoxygenase (i.e., arachidonate 5-lipoxygenase).The synthesis of the target compounds was achieved using polymer-supported carbamic acid (4-hydroxyphenyl)methyl 4-nitrophenyl ester and a chromene derivative [i.e., 2-methyl-2-(2-phenylethyl)-2H-1-benzopyran-6-amine] as reactants.Compounds including N-[(2-fluorophenyl)methyl]-2-methyl-2-(2-phenylethyl)-2H-1-benzopyran-6-amine, N-[(4-fluorophenyl)methyl]-2-methyl-2-(2-phenylethyl)-2H-1-benzopyran-6-amine and 2-methyl-N-[(5-methyl-2-thienyl)methyl]-2-(2-phenylethyl)-2H-1-benzopyran-6-amine were identified as most active.