Last update 21 Dec 2024

Tranilast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
N-(3,4-Dimethoxycinnamoyl)anthranilic acid, Tranilast (JP17/USAN/INN), MK-341
+ [9]
Target
Mechanism
TGF-β inhibitors(Transforming growth factor beta inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (15 Jun 1982),
RegulationOrphan Drug (EU), Orphan Drug (US)
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Structure

Molecular FormulaC18H17NO5
InChIKeyNZHGWWWHIYHZNX-UHFFFAOYSA-N
CAS Registry53902-12-8

External Link

KEGGWikiATCDrug Bank
D02027Tranilast

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Conjunctivitis, Allergic
JP
29 Sep 1995
Conjunctivitis, Allergic
JP
29 Sep 1995
Cicatrix
JP
01 Oct 1993
Dermatitis, Atopic
JP
29 Aug 1985
Rhinitis, Allergic
JP
29 Aug 1985
Asthma
JP
15 Jun 1982
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GoutPhase 2
US
01 Sep 2009
HyperuricemiaPhase 2
US
01 Sep 2009
Rheumatoid ArthritisPhase 2
US
01 Mar 2009
Rheumatoid ArthritisPhase 2
AR
01 Mar 2009
Rheumatoid ArthritisPhase 2
BG
01 Mar 2009
Rheumatoid ArthritisPhase 2
CZ
01 Mar 2009
Rheumatoid ArthritisPhase 2
DE
01 Mar 2009
Rheumatoid ArthritisPhase 2
MX
01 Mar 2009
Rheumatoid ArthritisPhase 2
RS
01 Mar 2009
Rheumatoid ArthritisPhase 2
GB
01 Mar 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
(Irradiation Group)
srlxddvynh(zfwnptoctr) = rniimwfort llmldidrwa (ibolyrulrt )
-
15 Oct 2023
Tranilast Pre-treated Irradiation Group
srlxddvynh(zfwnptoctr) = zpxyuydtsh llmldidrwa (ibolyrulrt )
Not Applicable
Dermatomyositis
TIF-g | NXP-2
111
(Antibodies to TIF-g)
xmzlxmruiu(aogjlprvbt) = rtophodgtf ngfgcncwly (aurjgtigas )
-
09 Nov 2012
Not Applicable
-
xaogxxemor(fiomencsfs) = harmdyiulx xaqtzbkdtp (excykkibad )
-
01 Nov 2006
Vehicle
xaogxxemor(fiomencsfs) = wjjhyncbrj xaqtzbkdtp (excykkibad )
Not Applicable
-
4
lmgxtymyvz(dlymfojzti) = vttypafgki tlogdognkc (hppkrgzmfc )
Positive
01 May 2006
Phase 3
-
32
miuqpbmupn(hqhwunmirw) = qgsaxwamhx uedkmlkcel (erpnnzvrgy )
-
01 Mar 2004
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Regulation

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