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DUBLIN, July 20, 2023 /PRNewswire/ -- The "Post-Traumatic Stress Disorder Therapeutics Global Market Report 2023" report has been added to ResearchAndMarkets.com's offering. This comprehensive report provides critical information for strategists, marketers, and senior management to assess the post-traumatic stress disorder (PTSD) therapeutics market. The market is projected to grow from $3.15 billion in 2022 to $3.42 billion in 2023, with a compound annual growth rate (CAGR) of 8.72%. Furthermore, the market is expected to reach $4.82 billion by 2027, exhibiting a CAGR of 8.96%. Major players in the post-traumatic stress disorder therapeutics market include Novartis AG, Pfizer Inc., Bionomics Ltd., Apotex Inc., GlaxoSmithKline PLC., Otsuka Pharmaceutical Co. Ltd., Eli Lilly and Company, Aurobindo Pharma Limited, Merck KGaA, Sun Pharmaceuticals Pvt Ltd., Strategic Behavioral Health, Jazz Pharmaceuticals, Bionomics, Behavioral Health Network Inc., AstraZeneca PLC., Apotex Inc., Prometheon Pharma LLC., Ligand Pharmaceuticals Incorporated, Lycera Corp., and JSC Valenta Pharm. Reasons to Purchase: Gain a comprehensive global perspective with detailed coverage of 50+ geographies. Understand the market's response to COVID-19 and its impact as the virus abates. Assess the direct and indirect effects of the Russia-Ukraine war on agriculture, energy, mineral commodity supply, and the market. Measure the influence of high global inflation on market growth. Develop regional and country-specific strategies based on localized data and analysis. Identify investment opportunities in growth segments. Outperform competitors using forecast data and insights into market drivers and trends. Understand customer dynamics based on the latest market shares. Benchmark performance against key competitors. Support internal and external presentations with reliable high-quality data and analysis. Post-traumatic stress disorder therapeutics encompass treatments used to address PTSD, a mental health condition triggered by experiencing or witnessing traumatic events. These therapies aim to improve patients' cognitive abilities, physical activity, and regain a sense of control over their lives. Treatment modalities for PTSD include medication, therapy, self-care, and nutrition. The main drug categories in PTSD therapeutics include antidepressants, anti-anxiety medications, antihypertensive drugs, monoamine oxidase inhibitors (MAOIs), antipsychotics or second-generation antipsychotics (SGAs), beta-blockers, and others (such as benzodiazepines). Antidepressants are used to manage addiction and treat conditions like major depressive disorder, anxiety disorders, and chronic pain. Therapeutic services cater to different age groups, including pediatric, geriatric, and adults, and are provided by mental health centers, hospitals, outpatient clinics, and other facilities. Strategic collaborations, funding, and investments are emerging trends in the PTSD therapeutics market, with major companies forging partnerships and investing in other organizations to strengthen their market position. For example, in January 2022, Professor Dan Lubman AM, Dr. Shalini Arunogiri, and Dr. Paul Liknaitzky of Monash University received over $1.9 million to study the effectiveness of MDMA-assisted psychological treatment for alcohol use disorder (AUD) and PTSD. This research initiative is part of seven clinical studies under the Medical Research Future Fund (MRFF), supported by the Australian Federal Government, to explore the use of potentially groundbreaking combination therapies for debilitating mental illnesses. North America dominated the post-traumatic stress disorder therapeutics market in 2022, while Asia-Pacific is expected to witness the highest growth during the forecast period. The regions covered in the report include Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, and Africa. Key countries analyzed in the report include Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, and USA. The increasing burden of PTSD cases worldwide is expected to drive the growth of the post-traumatic stress disorder therapeutics market. PTSD is a disorder that develops in individuals who have experienced or witnessed scary, shocking, or dangerous events. Therapeutic interventions, including psychotherapy and medication, play a crucial role in helping individuals regain a sense of control over their lives. According to the United States Department of Veterans Affairs, nearly 8 million Americans were estimated to be suffering from PTSD in 2021. The rising burden of PTSD cases underscores the need for effective therapeutics and fuels the growth of the post-traumatic stress disorder therapeutics market. The post-traumatic stress disorder therapeutics market includes revenues earned by entities providing treatment services such as psychotherapy, medication, and combination therapies. The market value comprises the value of related goods and services sold by the service providers. The market also includes sales of specific drugs used in PTSD treatment, such as Sertraline, Paroxetine, and Fluoxetine. Key Topics Covered: 1. Executive Summary 2. Post-Traumatic Stress Disorder Therapeutics Market Characteristics 3. Post-Traumatic Stress Disorder Therapeutics Market Trends And Strategies 4. Post-Traumatic Stress Disorder Therapeutics Market - Macro Economic Scenario 4.1. COVID-19 Impact On Post-Traumatic Stress Disorder Therapeutics Market 4.2. Ukraine-Russia War Impact On Post-Traumatic Stress Disorder Therapeutics Market 4.3. Impact Of High Inflation On Post-Traumatic Stress Disorder Therapeutics Market 5. Post-Traumatic Stress Disorder Therapeutics Market Size And Growth 5.1. Global Post-Traumatic Stress Disorder Therapeutics Historic Market, 2017-2022, $ Billion 5.1.1. Drivers Of The Market 5.1.2. Restraints On The Market 5.2. Global Post-Traumatic Stress Disorder Therapeutics Forecast Market, 2022-2027F, 2032F, $ Billion 5.2.1. Drivers Of The Market 5.2.2. Restraints On the Market 6. Post-Traumatic Stress Disorder Therapeutics Market Segmentation 6.1. Global Post-Traumatic Stress Disorder Therapeutics Market, Segmentation By Drug Class, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion Antidepressants Anti-Anxiety Antihypertensive Monoamine Oxidase (MAOs) Antipsychotics Or Second Generation Antipsychotics (SGOs) Beta-Blockers Other Classes 6.2. Global Post-Traumatic Stress Disorder Therapeutics Market, Segmentation By Age Group, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion Pediartic Geriatric Adult 6.3. Global Post-Traumatic Stress Disorder Therapeutics Market, Segmentation By End User, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion Mental Health Center Hospitals Outpaitent Clinics Other End Users 7. Post-Traumatic Stress Disorder Therapeutics Market Regional And Country Analysis 7.1. Global Post-Traumatic Stress Disorder Therapeutics Market, Split By Region, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion 7.2. Global Post-Traumatic Stress Disorder Therapeutics Market, Split By Country, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

Using surveys, cognitive tests and brain imaging, researchers have identified a type of depression that affects about a quarter of patients. The goal is to diagnose and treat the condition more precisely. Scientists at Stanford Medicine conducted a study describing a new category of depression -- labeled the cognitive biotype -- which accounts for 27% of depressed patients and is not effectively treated by commonly prescribed antidepressants. Cognitive tasks showed that these patients have difficulty with the ability to plan ahead, display self-control, sustain focus despite distractions and suppress inappropriate behavior; imaging showed decreased activity in two brain regions responsible for those tasks. Because depression has traditionally been defined as a mood disorder, doctors commonly prescribe antidepressants that target serotonin (known as selective serotonin reuptake inhibitors or SSRIs), but these are less effective for patients with cognitive dysfunction. Researchers said that targeting these cognitive dysfunctions with less commonly used antidepressants or other treatments may alleviate symptoms and help restore social and occupational abilities. The study, published June 15 in JAMA Network Open, is part of a broader effort by neuroscientists to find treatments that target depression biotypes, according to the study's senior author, Leanne Williams, PhD, the Vincent V.C. Woo Professor and professor of psychiatry and behavioral sciences. "One of the big challenges is to find a new way to address what is currently a trial-and-error process so that more people can get better sooner," Williams said. "Bringing in these objective cognitive measures like imaging will make sure we're not using the same treatment on every patient." Finding the biotype In the study, 1,008 adults with previously unmedicated major depressive disorder were randomly given one of three widely prescribed typical antidepressants: escitalopram (brand name Lexapro) or sertraline (Zoloft), which act on serotonin, or venlafaxine-XR (Effexor), which acts on both serotonin and norepinephrine. Seven hundred and twelve of the participants completed the eight-week regimen. Before and after treatment with the antidepressants, the participants' depressive symptoms were measured using two surveys -- one, clinician-administered, and the other, a self-assessment, which included questions related to changes in sleep and eating. Measures on social and occupational functioning, as well as quality of life, were tracked as well. The participants also completed a series of cognitive tests, before and after treatment, measuring verbal memory, working memory, decision speed and sustained attention, among other tasks. Before treatment, scientists scanned 96 of the participants using functional magnetic resonance imaging as they engaged in a task called the "GoNoGo" that requires participants to press a button as quickly as possible when they see "Go" in green and to not press when they see "NoGo" in red. The fMRI tracked neuronal activity by measuring changes in blood oxygen levels, which showed levels of activity in different brain regions corresponding to Go or NoGo responses. Researchers then compared the participants' images with those of individuals without depression. The researchers found that 27% of the participants had more prominent symptoms of cognitive slowing and insomnia, impaired cognitive function on behavioral tests, as well as reduced activity in certain frontal brain regions -- a pro labeled the cognitive biotype. "This study is crucial because psychiatrists have few measurement tools for depression to help make treatment decisions," said Laura Hack, MD, PhD, the lead author of the study and an assistant professor of psychiatry and behavioral sciences. "It's mostly making observations and self-report measures. Imaging while performing cognitive tasks is rather novel in depression treatment studies." Pre-treatment fMRI showed those with the cognitive biotype had significantly reduced activity in the dorsolateral prefrontal cortex and dorsal anterior cingulate regions during the GoNoGo task compared with the activity levels in participants who did not have the cognitive biotype. Together, the two regions form the cognitive control circuit, which is responsible for limiting unwanted or irrelevant thoughts and responses and improving goal selection, among other tasks. After treatment, the researchers found that for the three antidepressants administered, the overall remission rates -- the absence of overall depression symptoms -- were 38.8% for participants with the newly discovered biotype and 47.7% for those without it. This difference was most prominent for sertraline, for which the remission rates were 35.9% and 50% for those with the biotype and those without, respectively. "Depression presents in different ways in different people, but finding commonalities -- like similar profiles of brain function -- helps medical professionals effectively treat participants by individualizing care," Williams said. Depression isn't one size fits all Williams and Hack propose that behavior measurement and imaging could help diagnose depression biotypes and lead to better treatment. A patient could complete a survey on their own computer or in the doctor's office, and if they are found to display a certain biotype, they might be referred to imaging for confirmation before undergoing treatment. Researchers at the Stanford Center for Precision Mental Health and Wellness, which Williams directs, in partnership with the Stanford Translational Precision Mental Health Clinic, which Hack directs, are studying another medication -- guanfacine -- that specifically targets the dorsolateral prefrontal cortex region with support from Stanford University Innovative Medicines Accelerator. They believe this treatment could be more effective for patients with the cognitive subtype. Williams and Hack hope to conduct studies with participants who have the cognitive biotype, comparing different types of medication with treatments such as transcranial magnetic stimulation and cognitive behavioral therapy. In transcranial magnetic stimulation, commonly referred to as TMS, magnetic fields stimulate nerve cells; in cognitive behavioral therapy, patients are taught to use problem-solving strategies to counter negative thoughts that contribute to both emotional dysregulation and loss of social and occupational abilities. "I regularly witness the suffering, the loss of hope and the increase in suicidality that occurs when people are going through our trial-and-error process," Hack said. "And it's because we start with medications that have the same mechanism of action for everyone with depression, even though depression is quite heterogeneous. I think this study could help change that." Researchers from the Sierra-Pacific Mental Illness Research, Education and Clinical Center; the Veterans Affairs Palo Alto Health Care System; Brain Dynamic Centre, Westmead Institute for Medical Research; and the University of Sydney, Westmead, contributed to the work. The study was funded through Brain Resource Company Operations Pty Ltd. and Stanford University's Clinical and Translation Science Award Program overseen by the National Center for Advancing Translational Sciences at the National Institutes of Health (grant UL1TR003142-01).