Drug Type Virus-like particle vaccine, Synthetic peptide vaccine, Therapeutic vaccine |
Synonyms Alzheimer's disease virus-like particle-based vaccine, Alzheimer's disease VLP-based vaccine, Beta-amyloid protein immunotherapy + [2] |
Target |
Mechanism APP inhibitors(Beta amyloid A4 protein inhibitors), Immunostimulants |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Alzheimer Disease | Phase 3 | US | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | AU | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | BE | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | CA | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | FI | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | DE | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | NL | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | ES | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | CH | 30 Nov 2015 | |
Alzheimer Disease | Phase 3 | GB | 30 Nov 2015 |
Not Applicable | - | 65 | dfoxoodyxv(wmqmxubeiv) = bpmfqqmdnv vabipheptv (yelpwswmjr ) View more | Positive | 31 Dec 2021 | ||
Placebo | dfoxoodyxv(wmqmxubeiv) = gosfpysbrq vabipheptv (yelpwswmjr ) View more | ||||||
NCT01097096 (Pubmed) Manual | Phase 2 | 121 | wvghclvwkf(mmdtznovpr) = uyyqiopftu ntybgqsjne (abmufufhxl, 16.7 - 33.8) | Positive | 23 Dec 2016 | ||
Placebo | wvghclvwkf(mmdtznovpr) = dxmdfhzxaw ntybgqsjne (abmufufhxl, 0.2 - 31.9) | ||||||
Not Applicable | - | vfntgotvsu(thrumqxhiv) = AEs occurred in 74.5% of CAD106-treated patients versus 63.6% of placebo-treated patients (core), and 82.2% experienced AEs during extension studies. Most AEs were mild to moderate in severity, were not study medication-related and did not require discontinuation. SAEs occurred in 19.1% of CAD106-treated patients and 36.4% of placebo-treated patients (core). One patient (CAD106-treated; 2201) reported a possibly study drug-related SAE of intracerebral hemorrhage. Four patients met criteria for amyloid-related imaging abnormalities (ARIA) corresponding to microhemorrhages: one was CAD106-treated (2201), one placebo-treated (2202) and two open-label CAD106-treated. No ARIA corresponded to vasogenic edema. Two patients discontinued extension studies because of SAEs (rectal neoplasm and rapid AD progression, respectively). myrsmneoqt (gtctmgagrf ) | - | 01 Jan 2015 |