Last update 05 Nov 2024

Amilomotide

Overview

Basic Info

Drug Type
Virus-like particle vaccine, Synthetic peptide vaccine, Therapeutic vaccine
Synonyms
Alzheimer's disease virus-like particle-based vaccine, Alzheimer's disease VLP-based vaccine, Beta-amyloid protein immunotherapy
+ [2]
Target
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), Immunostimulants
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 3
US
30 Nov 2015
Alzheimer DiseasePhase 3
AU
30 Nov 2015
Alzheimer DiseasePhase 3
BE
30 Nov 2015
Alzheimer DiseasePhase 3
CA
30 Nov 2015
Alzheimer DiseasePhase 3
FI
30 Nov 2015
Alzheimer DiseasePhase 3
DE
30 Nov 2015
Alzheimer DiseasePhase 3
NL
30 Nov 2015
Alzheimer DiseasePhase 3
ES
30 Nov 2015
Alzheimer DiseasePhase 3
CH
30 Nov 2015
Alzheimer DiseasePhase 3
GB
30 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
65
dfoxoodyxv(wmqmxubeiv) = bpmfqqmdnv vabipheptv (yelpwswmjr )
Positive
31 Dec 2021
Placebo
dfoxoodyxv(wmqmxubeiv) = gosfpysbrq vabipheptv (yelpwswmjr )
Phase 2
121
wvghclvwkf(mmdtznovpr) = uyyqiopftu ntybgqsjne (abmufufhxl, 16.7 - 33.8)
Positive
23 Dec 2016
Placebo
wvghclvwkf(mmdtznovpr) = dxmdfhzxaw ntybgqsjne (abmufufhxl, 0.2 - 31.9)
Not Applicable
-
vfntgotvsu(thrumqxhiv) = AEs occurred in 74.5% of CAD106-treated patients versus 63.6% of placebo-treated patients (core), and 82.2% experienced AEs during extension studies. Most AEs were mild to moderate in severity, were not study medication-related and did not require discontinuation. SAEs occurred in 19.1% of CAD106-treated patients and 36.4% of placebo-treated patients (core). One patient (CAD106-treated; 2201) reported a possibly study drug-related SAE of intracerebral hemorrhage. Four patients met criteria for amyloid-related imaging abnormalities (ARIA) corresponding to microhemorrhages: one was CAD106-treated (2201), one placebo-treated (2202) and two open-label CAD106-treated. No ARIA corresponded to vasogenic edema. Two patients discontinued extension studies because of SAEs (rectal neoplasm and rapid AD progression, respectively). myrsmneoqt (gtctmgagrf )
-
01 Jan 2015
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Core Patent

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Clinical Trial

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Approval

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Regulation

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