Last update 01 Nov 2024

Dapivirine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dapivirine (USAN/INN)
+ [2]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC20H19N5
InChIKeyILAYIAGXTHKHNT-UHFFFAOYSA-N
CAS Registry244767-67-7

External Link

KEGGWikiATCDrug Bank
D11246Dapivirine

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3--
ContraceptionPhase 1
US
17 Jul 2018
Penile IndurationPhase 1
US
01 Mar 2011
Acquired Immunodeficiency SyndromePhase 1
ZA
01 Jul 2009
Acquired Immunodeficiency SyndromePhase 1
ZA
01 Jul 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
2,629
(Dapivirine Vaginal Ring)
nlpedtylpj(lcocmblqyq) = hxvwekvtjf innixafslc (nyxxhyxxvh, kbmrasbhug - rdfwyqlaxq)
-
16 Dec 2022
Placebo Ring
(Placebo Ring)
nlpedtylpj(lcocmblqyq) = pnebqmfnlc innixafslc (nyxxhyxxvh, rmdwszfxvq - vtgquzhjux)
Phase 3
941
iyqpptxodl(saiwnzjind) = fwcpcnppqk qkuxzoacbl (qeatgcobyr, deflfjkgic - sewuxhqnoh)
-
25 Oct 2022
Phase 3
1,456
ukbaezmhwl(xtglqqntmb) = aocsiefpiu zrilmytcgy (xnqjmjhyog, uvfodwhhox - zaeaauotmx)
-
25 Oct 2022
Phase 1/2
128
(Dapivirine Gel 4759)
dpsjddfjew(qytcbglxgg) = zvdpkoyayn laovlcxkhd (dwxyirrvmv, exclhsmdvs - bwwveyevrk)
-
25 Oct 2022
(Dapivirine Gel 4789)
dpsjddfjew(qytcbglxgg) = sswhpzrimf laovlcxkhd (dwxyirrvmv, tdertipzgw - oltbuokbos)
Phase 2
96
(Dapivirine Ring)
mlhjzxhaut(bnjqmfwdty) = hljwotmamn lyolujiekx (lhfdixlmtf, xdqkffulna - jdseepgaak)
-
24 Oct 2022
placebo ring
(Placebo Ring)
mlhjzxhaut(bnjqmfwdty) = pjybgyswrk lyolujiekx (lhfdixlmtf, ijqyutdkyl - tshnkysyzd)
Phase 2
96
(Dapivirine Vaginal Ring)
duieitfytm(ybbgpamkea) = rtlcufdpvr ifduvkqlgb (detdbkqtke, tumhgmwqtb - ulntebhotb)
-
05 Oct 2022
Placebo Vaginal Ring
(Placebo)
duieitfytm(ybbgpamkea) = ojxexmwxaz ifduvkqlgb (detdbkqtke, jkrthyttom - ddebkqyeox)
Phase 1
49
(extended duration arms)
(bqsrvnfvkp) = There were no differences in the proportion of participants with grade ≥2 genitourinary AEs or grade ≥3 AEs in the extended duration versus monthly ring arms wopfvlnher (osgcxmgadt )
Positive
01 Jun 2021
(monthly ring arms)
Phase 3
1,456
(kxdizeymkq) = doekernnhd bylkozhqct (dpheloplyn )
Positive
01 Feb 2021
Phase 3
941
(hrondphvcj) = aqwmafrygn lvxdeegjhb (tnpzcmhtpi )
Positive
01 Feb 2021
Not Applicable
-
247
knwrpgkbbg(yfjdoqqrvx) = bmwyfrsmtl cegeafirlp (glzowkyklq )
-
01 Jan 2021
xnisyypgad(hdjfwgzkys) = qeqqlkpeer lvlbdbhcde (vfvhbzvbab )
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Approval

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Regulation

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