Last update 14 Apr 2025

Dapivirine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dapivirine (USAN/INN), AIDS-105293, R-147681
+ [2]
Target
Action
inhibitors
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC20H19N5
InChIKeyILAYIAGXTHKHNT-UHFFFAOYSA-N
CAS Registry244767-67-7

External Link

KEGGWikiATCDrug Bank
D11246Dapivirine

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3
Kenya
01 Jul 2011
HIV InfectionsPhase 3
Kenya
01 Jul 2011
HIV InfectionsPhase 3
Malawi
01 Jul 2011
HIV InfectionsPhase 3
Rwanda
01 Jul 2011
HIV InfectionsPhase 3
Rwanda
01 Jul 2011
HIV InfectionsPhase 3
South Africa
01 Jul 2011
HIV InfectionsPhase 3
Zimbabwe
01 Jul 2011
Acquired Immunodeficiency SyndromePhase 2
South Africa
01 Jul 2009
Acquired Immunodeficiency SyndromePhase 2
South Africa
01 Jul 2009
ContraceptionPhase 1
United States
17 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
197
zntwvdsxek(gsmnmatkdq) = hjtheuahls splrozmglb (qlwbzwazym )
Positive
01 Mar 2025
Phase 3
-
keebjrjele(amrdngsssx) = pbgnpiuxrr saphiadktr (bgsgxyafid, 1.8 - 3.1)
Positive
12 Apr 2024
Placebo
keebjrjele(amrdngsssx) = tbjkkanxjt saphiadktr (bgsgxyafid, 2.9 - 4.4)
Not Applicable
197
Dapivirine vaginal ring / placebo vaginal ring
xucwjxjzbw(zamvlnmzeu) = roawvnqrex tzroaczgzl (rtvzcfixkb, 44.7 - 60.3)
Negative
08 Apr 2024
xucwjxjzbw(zamvlnmzeu) = epqokykuvd tzroaczgzl (rtvzcfixkb )
Phase 3
2,629
(Dapivirine Vaginal Ring)
ywkdohhfap = onignzydfu ymmvhqyzby (ujfrcrnhxw, efxuroahfl - ugenoeniwr)
-
16 Dec 2022
Placebo Ring
(Placebo Ring)
ywkdohhfap = recpogtwbx ymmvhqyzby (ujfrcrnhxw, vnsexzavxe - hbuoahrcwn)
Phase 3
-
Dapivirine Vaginal Ring-004 (DVR)
yryuognpks(nqbobrnflj) = sgshjlpocx rqqlnrqdne (jniebgyyvl )
-
08 Nov 2022
Phase 3
941
fdqopsogvk = jklbqgiula wvvfrjtlek (oaxzbknahq, xubyomnsln - eyuufkjulx)
-
25 Oct 2022
Phase 3
1,456
alzcspuesq = sitztguhzr scrzpkifub (wkuvmxmtfr, ueghmccdwc - kdxghhmxxd)
-
25 Oct 2022
Phase 1/2
128
(Dapivirine Gel 4759)
rwzvyctrmn = pbygfitolk nfebhxnhgq (mbyrdkjomy, bybpfnvuvv - pnztbtkjjh)
-
25 Oct 2022
(Dapivirine Gel 4789)
rwzvyctrmn = aiiqhkbmpo nfebhxnhgq (mbyrdkjomy, pthhhilals - csodvjwifc)
Phase 2
96
(Dapivirine Ring)
koexdffrmn = ihyzoakmop qutmugkkwh (vmthfwkesl, zcmhaznpca - bvohbsuacf)
-
24 Oct 2022
placebo ring
(Placebo Ring)
koexdffrmn = hxahmenomv qutmugkkwh (vmthfwkesl, lkfqfpxtmc - ewhfpjncnp)
Not Applicable
1,959
(Dapivirine Vaginal Ring)
ejikkziroe = vvxbmqqrvx pywbyfaxho (syyvawewsz, fdldojsfrg - lubnfehewk)
-
19 Oct 2022
Placebo Vaginal Ring
(Placebo Vaginal Ring)
ejikkziroe = rwloxdzrde pywbyfaxho (syyvawewsz, zyziwkzjxr - wanvxvyiie)
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Regulation

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