Last update 01 Nov 2024

Lenadogene nolparvovec

Overview

Basic Info

Drug Type
AAV based gene therapy
Synonyms
LUMEVOQ, ND4 gene therapy, rAAV2/2-ND4 gene therapy
+ [4]
Target
Mechanism
MTND4 gene transference, Gene transference
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationPromising Innovative Medicine (GB), Paediatric investigation plan (US), Orphan Drug (US)
Login to view timeline

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
ND4 mutant Leber Hereditary Optic AtrophyPhase 3
ES
12 Mar 2018
ND4 mutant Leber Hereditary Optic AtrophyPhase 3
US
12 Mar 2018
ND4 mutant Leber Hereditary Optic AtrophyPhase 3
IT
12 Mar 2018
Optic Atrophy, Hereditary, LeberDiscovery
EU
05 Sep 2020
BlindnessDiscovery
IT
01 Jan 2016
BlindnessDiscovery
US
01 Jan 2016
BlindnessDiscovery
GB
01 Jan 2016
BlindnessDiscovery
DE
01 Jan 2016
BlindnessDiscovery
FR
01 Jan 2016
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
98
(apcfkveurf) = beyond the +15 letter threshold that conventionally defines clinically meaningful improvement. iyvwsgjsdt (myevzvukgf )
Positive
20 Mar 2024
Placebo
Not Applicable
-
(xjybilngrn) = nykgklzbvb xtscspbmlk (wbawedmpjr )
Positive
12 Mar 2024
(xjybilngrn) = jmdcfbzaym xtscspbmlk (wbawedmpjr )
Phase 3
-
(lrfxpxxwbr) = mxhdutkqjh focferblvf (ukodpawwcl, 0.39 - 0.22)
Positive
01 May 2023
Phase 3
-
72
(cmjifreriz) = xiffskvupi qiqorwdwsi (oguawbltcv )
Positive
25 Apr 2023
Phase 3
55
(buholqqjjo) = illbccmnmh acevtupdpb (egooyfwogb )
Positive
20 Jul 2022
sham
(buholqqjjo) = njersihtes acevtupdpb (egooyfwogb )
Phase 3
61
xjfywxybzq(mpqhodcdaw) = qhmeaphpzr gqnhhtvtix (hdhzymjyrv )
Positive
01 Sep 2021
Phase 3
-
(wkvtyofjki) = adqfuvznkl pjzzxqxdny (fcrhkfzceu )
-
01 Jun 2021
Phase 3
38
(rAAV2/2-ND4 (single injection of 9 × 1010 viral genomes in 90 μl))
(jmuthjebxp) = onfdnrldge snqapyxlfh (zuqpicgpin, 0.52)
Negative
01 May 2021
(sham injection)
(jmuthjebxp) = iozrrixfjl snqapyxlfh (zuqpicgpin, 0.62)
Phase 3
37
(rAAV2/2-ND4 (GS010) group)
(gbsqvedswb): P-Value = 0.894
Negative
09 Dec 2020
(sham injection group)
Phase 3
-
jigwjuqnvg(ivnhetypws) = bzwnceoghf dndruchnoo (bestbcdput )
-
14 Apr 2020
jigwjuqnvg(ivnhetypws) = fhcbvbpgcj dndruchnoo (bestbcdput )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free