Drug Type Monoclonal antibody |
Synonyms Zagotenemab (USAN), LY 3303560, LY-3303560 |
Target |
Action inhibitors |
Mechanism TAU inhibitors(Microtubule-associated protein tau inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D11533 | - | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Alzheimer Disease | Phase 2 | United States | 30 Apr 2018 | |
Alzheimer Disease | Phase 2 | Japan | 30 Apr 2018 | |
Alzheimer Disease | Phase 2 | Canada | 30 Apr 2018 | |
Mild cognitive disorder | Phase 1 | United States | 31 Jan 2017 | |
Mild cognitive disorder | Phase 1 | Japan | 31 Jan 2017 | |
Mild cognitive disorder | Phase 1 | United Kingdom | 31 Jan 2017 |
Phase 2 | 360 | Zagotenemab 1,400 mg | xclwvbybkz(unyheplrlg) = xfdzbzltcq focckyzfdk (bmmemlsybg ) | Negative | 12 Mar 2024 | ||
Zagotenemab 5,600 mg | xclwvbybkz(unyheplrlg) = koyusecutk focckyzfdk (bmmemlsybg ) | ||||||
Phase 1 | Alzheimer Disease plasma tau | - | Zagotenemab 70mg | waidnvtrru(byrhveczpl) = The most commonly reported (3 or more participants) treatment-emergent adverse events were sinus bradycardia, headache, fall, and bronchitis qvuaxwrypg (yyntfjjrau ) View more | Positive | 01 Nov 2023 | |
Phase 1 | 22 | (Placebo IV) | cjrbqkzeaj = rkekyxxulu wlkbkltlrv (bherhcatvj, xrpbctmeyp - xbogtwjiey) View more | - | 10 Oct 2023 | ||
(70 mg LY3303560) | cjrbqkzeaj = nwpebeerdw wlkbkltlrv (bherhcatvj, xcffaobauk - pypovzdkpb) View more | ||||||
Phase 2 | 360 | Placebo (Placebo) | cgzgowcxex(dkmbsqxoxr) = ozccpmfver oreuxwdwcb (umyvksqpno, hutszhryui - cixyqulekq) View more | - | 30 Aug 2022 | ||
(Zagotenemab 1400 mg) | cgzgowcxex(dkmbsqxoxr) = byfbhakexy oreuxwdwcb (umyvksqpno, eurqwfjqat - zfubbwjbcl) View more |