Drug Type Bispecific T-cell Engager (BiTE) |
Synonyms- |
Target |
Mechanism CD3 modulators(T cell surface glycoprotein CD3 modulators), PSMA modulators(Prostate-specific membrane antigen modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
squamous cell lung carcinoma | Phase 2 | DE | 02 Feb 2022 | |
Recurrent Prostate Carcinoma | Phase 1 | DE | 11 Nov 2022 | |
Castration-Resistant Prostatic Cancer | Phase 1 | DE | 15 Nov 2019 | |
Castration-Resistant Prostatic Cancer | Phase 1 | DE | 15 Nov 2019 |
Phase 1/2 | 28 | rgqhxuhkyu(zzuhqytbnk) = max. 2° wqffpyvyht (czqyfwqhxd ) View more | Positive | 24 May 2024 | |||
NCT04104607 (ASCO2023) Manual | Phase 1 | 24 | nrmmazjbkk(kasvykzlpg) = the most frequently observed toxicity being cytokine release syndrome (CRS, max. 2°) (88%) znqozrfjst (hvfhyaalvr ) | Positive | 26 May 2023 | ||
NCT04104607 (AACR2022) Manual | Phase 1 | 14 | zfclhxhaku(mnfdydfbxt) = Besides hypertension (observed in 50% of patients), no further CC-1 related toxicities (i.e., Xerostomia, or anaphylactic reaction) were observed. As expected, after prophylactic tocilizumab application decreased neutrophile counts and elevated liver enzymes were observed in 86% and 43% of patients, respectively. rbwnsywclk (jqdaknyqvd ) | Positive | 15 Jun 2022 |