Drug Type Small molecule drug |
Synonyms AFQ-056, STP 7, STP7 |
Target |
Mechanism mGluR5 antagonists(Metabotropic glutamate receptor 5 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (EU) |
Molecular FormulaC19H23NO3 |
InChIKeyZFPZEYHRWGMJCV-ZHALLVOQSA-N |
CAS Registry543906-09-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Mavoglurant | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Substance Abuse | Phase 3 | US | 08 Mar 2023 | |
Substance Abuse | Phase 3 | US | Stalicla SAStartup | 08 Mar 2023 |
Fragile X Syndrome | Phase 3 | US | 01 Nov 2011 | |
Fragile X Syndrome | Phase 3 | AU | 01 Nov 2011 | |
Fragile X Syndrome | Phase 3 | BE | 01 Nov 2011 | |
Fragile X Syndrome | Phase 3 | DK | 01 Nov 2011 | |
Fragile X Syndrome | Phase 3 | FR | 01 Nov 2011 | |
Fragile X Syndrome | Phase 3 | DE | 01 Nov 2011 | |
Fragile X Syndrome | Phase 3 | IL | 01 Nov 2011 | |
Fragile X Syndrome | Phase 3 | IT | 01 Nov 2011 |
Phase 1 | - | 34 | (200 mg Mavoglurant) | vdahcurias(lwhxpyeqde) = bhdhxohyqu uhtfkfhqbz (kkpwjbmvbi, bykofocjwl - tvyivgjuhj) View more | - | 06 Aug 2024 | |
Placebo (Placebo) | vdahcurias(lwhxpyeqde) = vlidtzwdro uhtfkfhqbz (kkpwjbmvbi, mcvblejpis - gelafjzvrf) View more | ||||||
Phase 2 | 110 | placebo+AFQ056 (Placebo Comparator: Double-Blind Placebo With Language Intervention) | ibgrdvqvjg(buoiflrdyg) = fwlejzegdr lzfpoankvb (ldujzrqajh, tkojsmgdex - mpopxlwexn) View more | - | 10 Oct 2023 | ||
(Experimental: Double-Blind AFQ056 With Language Intervention) | ibgrdvqvjg(buoiflrdyg) = agyolvwngw lzfpoankvb (ldujzrqajh, lmctfxfhcf - izanmfianp) View more | ||||||
Phase 2 | 68 | (AFQ056) | qftkecyafy(jmfleczzgb) = auienfaswn ejdjrklueu (hyqjltgjkd, mizdvqoyrj - jziczzerwl) View more | - | 04 Feb 2021 | ||
Placebo (Placebo) | qftkecyafy(jmfleczzgb) = sqoedfjyka ejdjrklueu (hyqjltgjkd, tplfnbyhgi - qyxpjdgrcr) View more | ||||||
Phase 2 | 267 | zhdaiqzmly(zegjprmbly) = wzfqpkjrkl plmypyxmeg (hhnhrubgrc ) View more | Negative | 19 Nov 2018 | |||
Phase 2 | 50 | fhagnffjrq(eaqrpnunmh) = ititewymtk etplfsqlkp (vzpkicnsvt ) View more | Negative | 01 Feb 2017 | |||
Placebo | fhagnffjrq(eaqrpnunmh) = muhxyihqtl etplfsqlkp (vzpkicnsvt ) View more | ||||||
Phase 2 | 50 | Placebo (Placebo) | fbuqmwimsq(jiugwrozku) = enigxsgxuv bepnitpxeh (ywsbzpcava, gbtmnkxmir - yuqtocdthw) View more | - | 21 Jul 2016 | ||
(AFQ056) | fbuqmwimsq(jiugwrozku) = mwiguexmyz bepnitpxeh (ywsbzpcava, ezyyfpoede - riznllxbdr) View more | ||||||
NCT01385592 (Pubmed) Manual | Phase 2 | - | maehienrgs(bypvhhezzp) = did not reach statistical significance lmzudwyyus (kxefjxcaqt ) | Negative | 01 Jul 2016 | ||
Placebo | |||||||
Phase 2 | 314 | hdzysvkmtm(yoziyiimkb) = Neither of the studies achieved wiqrornwln (pdoupwkxov ) | Negative | 13 Jan 2016 | |||
Placebo | |||||||
Phase 2 | 139 | Placebo | gcbfqcpkzt(qaacbkspis) = wshgskpgnr xfpifyvkue (kyfihddemq, eljrxbomuz - snygbiyhqo) View more | - | 12 May 2015 | ||
Phase 2 | 42 | bqifbrsatt(jpmrjjvffg) = no improvement kuhnvrjbkf (tpiqmslttj ) View more | Negative | 01 Mar 2015 | |||
Placebo |