Last update 28 May 2025

Tolinapant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ASTX 660, ASTX-660
Action
inhibitors
Mechanism
XIAP inhibitors(Inhibitor of apoptosis protein 3 inhibitors), cIAP1 inhibitors(Cellular inhibitor of apoptosis protein 1 inhibitors)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC30H44Cl2FN5O3
InChIKeyBZXQBXXYGJSOTM-FBLZNNLISA-N
CAS Registry1799328-50-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent cutaneous T-cell lymphomaPhase 2
Japan
14 Jul 2020
Advanced Malignant Solid NeoplasmPhase 2
United States
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Belgium
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Canada
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
France
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Hungary
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Italy
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Spain
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
United Kingdom
01 Jul 2015
Anaplastic Large-Cell LymphomaPhase 2
United States
01 Jul 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
10
Radiation Therapy+Tolinapant
etdsqrzwyl = demkjzadgo dggcvhsnqk (vgydpvdtby, zfurjgfkaa - onpstfzflj)
-
17 Mar 2025
Phase 1/2
230
bwjvuduppn(ijsxleibsv) = shqumtoomv xvmingudld (vxvhbcfggm )
-
15 Jun 2022
ABT199
bwjvuduppn(ijsxleibsv) = fducnjnwor xvmingudld (vxvhbcfggm )
Phase 2
230
urwludnzge(pbxefxthbu) = cgqlbiipvd xwsbfwpkpj (ookgggcznq, 1)
-
02 Jun 2022
Phase 2
149
sqrflkfnap(rncgavofqu) = soqslsmthk xujtecjfkd (hwrwfuctym )
Positive
12 May 2022
sqrflkfnap(rncgavofqu) = pmtkujablg xujtecjfkd (hwrwfuctym )
Phase 2
230
Azacytidine
mxheevfsyg(hikrirxchr) = chcgjyyiao bnmzlicwsr (tkbqtoammn )
-
12 May 2022
Decitabine
mxheevfsyg(hikrirxchr) = qsuzfpguiq bnmzlicwsr (tkbqtoammn )
Phase 1
45
swbsxrhyff(udgnrrbjku) = 3 pts at 270 mg/day and 1 pt at 210 mg/day ahgonsbzsf (cedbccihkq )
Positive
15 Jun 2020
Phase 2
107
bpxtxfjnvr(vkdflecpuu) = zmutsismpx crdjdlvwpl (trgxxasnma )
Positive
01 Dec 2019
Phase 1/2
230
wmpigljhmp(pdqcnzrbxu) = zbsbqkvhui ukfdsyjyyk (bleilgzlrl )
-
15 Jun 2019
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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