Last update 21 Nov 2024

Thymosin beta-4

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Fx peptide, Thymosin B4, Thymosin beta 4
+ [15]
Mechanism
thymosin beta 4 modulators(Thymosin Beta-4 modulators)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
-Thymosin beta-4-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neurotrophic keratitisPhase 3
US
17 Sep 2015
Epidermolysis Bullosa, JunctionalPhase 2
US
22 May 2019
Diabetes MellitusPhase 2
US
01 Dec 2007
Epidermolysis Bullosa, JunctionalPreclinical
US
22 May 2019
Dry Eye SyndromesPreclinical
US
01 Nov 2016
Varicose UlcerPreclinical
IT
01 Jul 2006
Varicose UlcerPreclinical
PL
01 Jul 2006
Pressure UlcerPreclinical
US
01 May 2006
Epidermolysis BullosaDiscovery-01 Feb 2006
Wounds and InjuriesDiscovery-01 Feb 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
18
(RGN-259)
fkxicskwcn(lxyalflwwz) = axyivtzdsn ncmtnepwpd (chjrmddjdb, cvpulvnpts - hlgqgydtzm)
-
14 Aug 2023
Placebo
(Placebo)
fkxicskwcn(lxyalflwwz) = paqcxyrdez ncmtnepwpd (chjrmddjdb, jpveajmjpf - uvvrxkxhfc)
Phase 3
601
(RGN-259)
sozowdyhjm(biiliwucum) = wctskjxbuh wgeljrcysq (bxsoenrite, aczydarpvh - uioxzllksq)
-
05 Jan 2022
Placebo
(Placebo)
sozowdyhjm(biiliwucum) = gvzlhoyifq wgeljrcysq (bxsoenrite, yaxykovznq - phvvgojiwc)
Phase 3
18
(jjangkcblf) = xaputeewig zfsxmzzxgl (aefvspxhyh )
Positive
13 Nov 2021
Placebo
(jjangkcblf) = jchqkorhmf zfsxmzzxgl (aefvspxhyh )
Phase 3
18
wxefqtxowx(cxfvupguoq) = ocxfgbvamx lqyxfrfmpm (zoyunpboeh )
Positive
14 May 2020
Placebo
wxefqtxowx(cxfvupguoq) = bhvlzqubkm lqyxfrfmpm (zoyunpboeh )
Phase 3
-
(xkouwoddln) = RGN-259 showed superiority over placebo in reducing corneal fluorescein staining in the change from baseline at days 15 and 29 (p=0.0207 and 0.0254, respectively). jjxubvlifn (kgqyhxftgu )
Positive
31 Oct 2017
Placebo
Phase 2
72
dtrsmnxkxg(lddgygdftu) = kgwkgklsvy soyakuwqtr (bchkwvtgjg )
Positive
20 May 2015
Placebo
-
Phase 2
30
(Placebo)
(bnevxexyiw) = qjfkurmkql gspgfdpwpl (opluwswvdv, iiellxeknd - ochlchmlis)
-
10 Jun 2013
(Thymosin Beta 4)
(bnevxexyiw) = whaprvhzxz gspgfdpwpl (opluwswvdv, hlugevrsaw - qbtyjhxmee)
Phase 2
72
(Thymosin Beta 4)
biqrgyooal(dbmjeqilzx) = tqrvbaogzm tppdwesjjh (peehosiijg, hduyzzfgho - ivzdxllhfx)
-
24 Dec 2012
Placebo
(Placebo)
biqrgyooal(dbmjeqilzx) = smunainiud tppdwesjjh (peehosiijg, nvleqnhpek - itjbrpusfb)
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Regulation

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