Delving into the Latest Updates on Piritramide with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Piritramide (INN)

+ [2]

Target

Opioid receptors

Mechanism

Opioid receptors agonists(Opioid receptors agonists)

Therapeutic Areas

Nervous System DiseasesNeoplasmsDigestive System Disorders

Active Indication

Pain, PostoperativeColorectal Cancer

Inactive Indication-

Originator Organization-

Active Organization

Palacky University

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC27H34N4O

InChIKeyIHEHEFLXQFOQJO-UHFFFAOYSA-N

CAS Registry302-41-0

The aim of this study is to assess and compare the efficacy of a serratus anterior plane (SAP) block and our current pain protocol (Patient Controlled Intravenous Analgesia with opioids) in the prevention and treatment of acute postoperative pain after totally endoscopic aortic valve replacement (AVR) surgery.

Start Date03 Dec 2020

Sponsor / Collaborator

Fortis Jessa Ram Hospital

NCT03700541 / CompletedPhase 4IIT

Influence of Peri-operative Opioid Analgesia on Circulating Tumor Cells in Patients Undergoing Laparoscopic Colorectal Cancer Surgery - Multi-center, Randomized Clinical Trial

To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.

Start Date07 Jan 2019

Sponsor / Collaborator-

NCT03700411 / CompletedPhase 4IIT

Influence of Peri-operative Opioid Analgesia on Circulating Tumor Cells in Patients Undergoing Open Colorectal Cancer Surgery - Multi-center, Randomized Clinical Trial

To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.

Start Date07 Jan 2019

Sponsor / Collaborator-

100 Clinical Results associated with Piritramide

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100 Translational Medicine associated with Piritramide

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100 Patents (Medical) associated with Piritramide

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419

Literatures (Medical) associated with Piritramide

01 Jun 2024·Journal of PeriAnesthesia Nursing

Simplified Pain Management Including Fentanyl TTS in PACU Patients With Hip Fracture Surgery to Improve Patients’ Well-Being: A Double-Blind Randomized Trial

Article

Author: Smigaj, Jana ; Papamargaritis, Vasileios ; Labmayr, Viktor ; Michaeli, Kristina ; Sandner-Kiesling, Andreas ; Rief, Martin ; Gebauer, David ; Reinbacher, Patrick ; Bornemann-Cimenti, Helmar ; Schittek, Gregor A

PURPOSEAdequate pain management is eminently relevant for elderly and more vulnerable patients with hip fractures in the setting of pre and postoperative pain. This study compares postoperative hip fracture patients treated with standard pain management with a variety of medications or an approach with only one option in each medication category (nonopioid: acetaminophen; opioid: fentanyl TTS 12,5 mcg/hour; rescue medication: piritramide) to simplify the treatment algorithm for nurses and improve patient well-being.DESIGNDouble-blind randomized controlled trial.METHODSThe sample was cognitively intact patients (N = 141) with hip fractures in a tertiary university hospital. Administration of fentanyl 12 mcg/hour transdermal therapeutic system was administered by the nurses in the postanesthesia care unit (PACU) to address basal wound pain to improve patient well-being and patient treatment in the PACU for 24 hours to better control for early complications.FINDINGSWell-being was equally increased in both groups in comparison to our preintervention data from 35.7% to over 60% and did not differ significantly between the intervention and control group. No statistically significant differences in numeric rating scale scores, rescue opioid dosage (piritramide i.v.) or in complications were present.CONCLUSIONSThis one-size-fits-all simplified pain management approach did not improve patient well-being or any other outcome but highlighted the importance of adequate pain management and a sufficient nurse-to-patient ratio.

01 Jun 2024·Regional Anesthesia & Pain Medicine

Serratus plane block versus standard of care for pain control after totally endoscopic aortic valve replacement: a double-blind, randomized controlled, superiority trial

Article

Author: Sermeus, Luc ; Stessel, Björn ; Vandenbrande, Jeroen ; van Hilst, Eline ; Jamaer, Bob ; Callebaut, Ina ; Blanco, Rafael ; Yilmaz, Alaaddin ; Packlé, Loren ; Jalil, Hassanin

IntroductionSerratus anterior plane block has been proposed to reduce opioid requirements after minimally invasive cardiac surgery, but high-quality evidence is lacking.MethodsThis prospective, double-blinded, randomized controlled trial recruited patients undergoing totally endoscopic aortic valve replacement. Patients in the intervention arm received a single-injection serratus anterior plane block on arrival to the intensive care unit added to standard of care. Patients in the control group received routine standard of care, including patient-controlled intravenous analgesia. Primary outcome was piritramide consumption within the first 24 hours after serratus anterior plane block placement. We hypothesized that compared with no block, patients in the intervention arm would consume 25% less opioids.ResultsSeventy-five patients were analyzed (n=38 in intervention arm, n=37 in control arm). When comparing the serratus anterior plane group with the control group, median 24-hour cumulative opioid use was 9 (IQR 6–19.5) vs 15 (IQR 11.3–23.3) morphine milligram equivalents, respectively (p<0.01). Also, pain scores at 4, 8 and 24 hours were lower in the intervention arm at 4, 8 and 24 hours, respectively.ConclusionCombined deep and superficial single-injection serratus anterior plane block is superior to standard of care in reducing opioid requirements and postoperative pain intensity up to 24 hours after totally endoscopic aortic valve replacement.Trial registration numberNCT04699422.

01 May 2024·CardioVascular and Interventional Radiology

Intravenous Opioid Medication with Piritramide Reduces the Risk of Pneumothorax During CT-Guided Percutaneous Core Biopsy of the Lung

Article

Author: Goetz, Andrea ; Uller, Wibke ; Poschenrieder, Florian ; Zeman, Florian ; Greiner, Barbara ; Hamer, Okka ; Lange, Tobias J ; Thurn, Sylvia ; Steer, Frederike Georgine ; Stroszczynski, Christian ; Hammer, Simone

AbstractPurposeCT-guided percutaneous core biopsy of the lung is usually performed under local anesthesia, but can also be conducted under additional systemic opioid medication. The purpose of this retrospective study was to assess the effect of intravenous piritramide application on the pneumothorax rate and to identify risk factors for post-biopsy pneumothorax.Materials and MethodsOne hundred and seventy-one core biopsies of the lung were included in this retrospective single center study. The incidence of pneumothorax and chest tube placement was evaluated. Patient-, procedure- and target-related variables were analyzed by univariate and multivariable logistic regression analysis.ResultsThe overall incidence of pneumothorax was 39.2% (67/171). The pneumothorax rate was 31.5% (29/92) in patients who received intravenous piritramide and 48.1% (38/79) in patients who did not receive piritramide. In multivariable logistic regression analysis periinterventional piritramide application proved to be the only independent factor to reduce the risk of pneumothorax (odds ratio 0.46, 95%-confidence interval 0.24, 0.88; p = 0.018). Two or more pleura passages (odds ratio 3.38, 95%-confidence interval: 1.15, 9.87; p = 0.026) and prone position of the patient (odds ratio 2.27, 95%-confidence interval: 1.04, 4.94; p = 0.039) were independent risk factors for a higher pneumothorax rate.ConclusionProcedural opioid medication with piritramide proved to be a previously undisclosed factor decreasing the risk of pneumothorax associated with CT-guided percutaneous core biopsy of the lung.Level of Evidence 4small study cohort.Graphic Abstract

100 Deals associated with Piritramide

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