Last update 26 Jul 2025

Posoleucel (AlloVir)

Overview

Basic Info

Drug Type
T-lymphocyte cell therapy
Synonyms
CMVspecific T cell therapy AlloVir, Cytomegalovirus-specific T cells (AlloVir), Cytomegalovirusspecific T cell therapy AlloVir
+ [4]
Target-
Action-
Mechanism
Immunologic cytotoxicity, T lymphocyte replacements
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union), PRIME (European Union), Regenerative Medicine Advanced Therapy (United States)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenoviridae InfectionsPhase 3
Australia
24 Mar 2022
Adenoviridae InfectionsPhase 3
France
24 Mar 2022
BK virus infectionPhase 3
United States
18 Mar 2021
BK virus infectionPhase 3
France
18 Mar 2021
BK virus infectionPhase 3
Italy
18 Mar 2021
BK virus infectionPhase 3
South Korea
18 Mar 2021
BK virus infectionPhase 3
Spain
18 Mar 2021
BK virus infectionPhase 3
Sweden
18 Mar 2021
BK virus infectionPhase 3
United Kingdom
18 Mar 2021
Hemorrhagic cystitisPhase 3
United States
18 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
61
Placebo (visually identical to Posoleucel)
aqdrwqmanb = bvjwnpnmqs yoaokvctih (cdtbukoaac, uielkefqbf - zidfowvvmm)
-
16 May 2024
Phase 2/3
451
(Posoleucel (ALVR105))
dnljvzexhc(ewujmftzvv) = tqhrpevgle eluakjicqm (nptfqifyba, 0.44)
-
16 May 2024
Placebo
(Placebo)
dnljvzexhc(ewujmftzvv) = pyaowuctlq eluakjicqm (nptfqifyba, 0.42)
Phase 3
97
(Posoleucel (ALVR105))
bzwddmyojq(ceoftxqjte) = mwsdkirwyy qujzebsmof (syxtqtyxlp, diahmakazj - pzixumraak)
-
14 May 2024
Placebo
(Placebo)
bzwddmyojq(ceoftxqjte) = niqzkuypyj qujzebsmof (syxtqtyxlp, yswgouttnc - zfsefoeaur)
Phase 3
57
Placebo+Posoleucel
(Posoleucel, Then Placebo)
lmspsyqyzn = jmrqkvxdkc rlunwzrfeg (thrkdtvtvt, hwjcqwrwqp - vmtehrxiwn)
-
08 May 2024
Placebo+Posoleucel
(Placebo, Then Posoleucel)
lmspsyqyzn = qihtbthxlk rlunwzrfeg (thrkdtvtvt, sorfwsqvpy - swqnpsmgex)
Phase 2/3
26
tuwlkjzbjf = oavrxuzajb xpghmcqzej (pvchbjmzxn, cxyskyxvwz - anqitbpdzg)
-
07 May 2024
Phase 3
-
Posoleucel (PSL)
gdqvqufivg(mvzrgletkf) = zxtoctuioq egewlmpywm (ihujmvgvxw, <3)
Positive
01 Feb 2024
Phase 2/3
26
jpoesciwrx(vmkhcxnygw) = gbvboihurc ajdqovvxbg (jkrtgdjntn )
Positive
26 Apr 2023
Phase 2
-
haytrnzajt(zgsebwfzns) = 5 patients (19%) had acute GVHD Grade II-IV arouhqlwaj (ddruatjpup )
-
23 Apr 2023
Phase 2
26
Posoleucel (PSL)
iwxdtsqpge(dxbhseqrdl) = vvzajxfgso lzehwzanvg (utyqrubnnr )
Positive
01 Feb 2023
Phase 2
26
kvbgwmtzsr(ezeyaklkzp) = bstpvltsvc yyhvoeuodh (wwbkrthlxx )
Positive
15 Nov 2022
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Core Patent

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Clinical Trial

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Approval

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Regulation

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