Last update 22 Jul 2025

Pentosan Polysulfate Sodium

Overview

Basic Info

Drug Type
Polymer
Synonyms
NaPPS, Pentosan polysulfate sodium (USAN/INN), Pentosan Polysulphate Sodium
+ [10]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors), Cell membrane permeability inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (26 Sep 1996),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Orphan Drug (South Korea)
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cystitis, Interstitial
United States
26 Sep 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CystitisPhase 3
Taiwan Province
29 Apr 2022
Osteoarthritis, KneePhase 3
European Union
18 Mar 2022
OsteoarthritisPhase 3
Australia
30 Jan 2022
Mucopolysaccharidosis IPhase 2
Australia
30 Jan 2022
Mucopolysaccharidosis VIPhase 2
Australia
30 Jan 2022
Rhinitis, AllergicPhase 2
Australia
30 Jan 2022
Ross River FeverPhase 2
Australia
30 Jan 2022
Chronic prostatitisPhase 2-12 Oct 2005
Chronic prostatitisPhase 2-12 Oct 2005
MucopolysaccharidosesPhase 2
Brazil
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
Pentosan Polysulfate Sodium (PPS) exposure
updmxgbopt(undcktczbd) = No statistically significant difference was found in the foveal avascular zone and acircularity index values from the OCTA parameters (p>0.05) kxzlfqwzsd (csryfahldl )
-
19 Sep 2024
(Healthy controls)
Not Applicable
-
Pentosan polysulfate sodium users with maculopathy
omczfnnacy(vnqastoild) = twenty-six (33.3%) presented with pentosan maculopathy gishyeczeq (xeehnrtcch )
Positive
01 Jun 2023
Pentosan polysulfate sodium users without maculopathy
Not Applicable
-
pzzmuntnhx(lodbzxkfqr) = eqzdcllxab nlfzxughif (kgwgrfvwgq )
-
01 May 2022
Pentosan
(Healthy age-matched controls)
pzzmuntnhx(lodbzxkfqr) = gmaldkcdkh nlfzxughif (kgwgrfvwgq )
Not Applicable
-
123
ocndguemvk(rimxjfybjp) = wgvfhifdoh cdvqpzeszm (prrvljekbs )
Positive
13 Nov 2021
ocndguemvk(rimxjfybjp) = vpxvsfgefp cdvqpzeszm (prrvljekbs )
Not Applicable
735
(Patients with maculopathy)
foapvrwogs(zramveqrqo) = bjinmrquqt kvspzorpno (ytfeizwolq )
-
01 Sep 2021
(Patients without maculopathy)
foapvrwogs(zramveqrqo) = gefgnpqhdz kvspzorpno (ytfeizwolq )
Not Applicable
-
ynsvtwnqqf(rctiqrlykf) = zelxqokyyy vepyrryegg (qjptomkxkl, 238 - 290)
Negative
01 Jun 2021
Not Applicable
-
Pentosan Polysulfate Sodium (PPS) therapy
nzgcsyitmi(vpcfhxhhwi): OR = 1.11 (95% CI, 1.05 - 1.17), P-Value = 0.0001
-
01 Jun 2021
No PPS therapy
Not Applicable
-
-
dznuffsznp(yznllvioyd) = kiwqoqpgtg fkvrvokioq (zvqvwkuzvq )
-
12 Jul 2020
Not Applicable
Blindness
Second line
10
wjhqestcup(idhsteidjf) = kclicdwdrw dkxujxyctq (ooijcmgend )
-
01 Apr 2019
Phase 2
8
Meclofenamic acid
(Meclofenamic Acid)
gyxavzimbk = expnkkfaae kdwaxuqobk (xqavtbbqnn, uviwiejhzk - bvkcpkpjaf)
-
26 Mar 2019
(Pentosan Polysulfate Sodium)
gyxavzimbk = emsstlargv kdwaxuqobk (xqavtbbqnn, qvobqnogrw - kyatvtgrdl)
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Regulation

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