Last update 08 May 2025

Chlorothiazide/Methyldopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ALDOCLOR-250, Aldoclor-150
Target
ADRA2 x NCC
Action
agonists, inhibitors
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Therapeutic Areas
Cardiovascular Diseases
Active Indication-
Inactive Indication
Hypertension
Originator Organization
Merck Sharp & Dohme Corp.Merck Sharp & Dohme Corp.
Active Organization-
Inactive Organization
Merck & Co., Inc.Merck & Co., Inc.
License Organization-
Drug Highest PhaseWithdrawn
First Approval Date
United States (20 Mar 1968),
Hypertension
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC7H6ClN3O4S2
InChIKeyJBMKAUGHUNFTOL-UHFFFAOYSA-N
CAS Registry58-94-6
View All Structures (2)

Related

100 Clinical Results associated with Chlorothiazide/Methyldopa
Login to view more data
100 Translational Medicine associated with Chlorothiazide/Methyldopa
Login to view more data
100 Patents (Medical) associated with Chlorothiazide/Methyldopa
Login to view more data
2
Literatures (Medical) associated with Chlorothiazide/Methyldopa
01 Jan 1970Southern Medical JournalQ4 · MEDICINE
Methyldopa-Chlorothiazide—A Long-Term Evaluation
Q4 · MEDICINE
01 Mar 1965Journal of the South Carolina Medical Association
RESULTS OF METHYLDOPA-CHLOROTHIAZIDE THERAPY IN HYPERTENSIVE PATIENTS WITH RENAL DISEASE.
100 Deals associated with Chlorothiazide/Methyldopa
Login to view more data

External Link

KEGGWikiATCDrug Bank
--
C02LB01
-

R&D Status

Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
login
or
view full example data
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
login
or
view full example data
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
login
or
view full example data
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
login
or
view full example data
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
login
or
view full example data
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
login
or
view full example data
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free