Last update 21 Nov 2024

Demcizumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-DLL4 monoclonal antibody(OncoMed Pharmaceuticals), Anti-delta-like ligand 4 monoclonal antibody(OncoMed Pharmaceuticals), Demcizumab (USAN/INN)
+ [2]
Target
Mechanism
DLL4 inhibitors(Delta-like protein 4 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D10353Demcizumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
metastatic non-small cell lung cancerPhase 2
IT
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
US
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
BE
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
AU
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
BE
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
IT
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
ES
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
ES
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
US
01 Feb 2015
metastatic non-small cell lung cancerPhase 2
AU
01 Feb 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
82
Placebo
(Placebo/Placebo Arm (Arm 1))
wkhpcpbgtl(efsitgcjch) = vzwtkudnhg asfprcxzac (gapdarlqcr, aezlrukfxu - tiroflzgvb)
-
20 Aug 2018
Demcizumab+Placebo
(Demcizumab/Placebo Arm (Arm 2))
wkhpcpbgtl(efsitgcjch) = gvykdwukql asfprcxzac (gapdarlqcr, dacxuniurr - evfiwfronz)
Phase 2
207
Placebo
(Placebo/Placebo Arm)
jhuhztxwmy(dlzcvimeeh): Hazard Ratio (HR) = .930 (95% CI, 0.630 - 1.375), P-Value = 0.7158
-
08 Aug 2018
Demcizumab+Placebo
(Demcizumab/Placebo and Demcizumab/Demcizumab)
Phase 1
46
pemetrexed+carboplatin+Demcizumab
(ymhitieuso) = vdwkbkuiro vhsxwlhpbr (ivahmazjjc )
Positive
01 Feb 2018
Phase 2
82
(rpmwnimuiy) = bamawhpiti rdvdurrzzn (tmclhvmtfu )
Negative
08 May 2017
(rpmwnimuiy) = gkzvckqefa rdvdurrzzn (tmclhvmtfu )
Phase 1
56
gemcitabine+demcizumab
(plurjrmzmy) = DEM was limited to 70 days in cohorts 4, 5, 6 & 7. cmnhbnjuly (vocxjetjks )
Positive
01 Feb 2016
Phase 1
57
(fknhesdddk) = wxcldtkgla detbkqojdv (ptkwovfqdv )
-
20 Jan 2014
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Regulation

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