Drug Type Monoclonal antibody |
Synonyms Anti-DLL4 monoclonal antibody(OncoMed Pharmaceuticals), Anti-delta-like ligand 4 monoclonal antibody(OncoMed Pharmaceuticals), Demcizumab (USAN/INN) + [2] |
Target |
Mechanism DLL4 inhibitors(Delta-like protein 4 inhibitors) |
Therapeutic Areas |
Active Indication- |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
RegulationOrphan Drug (US) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10353 | Demcizumab | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
metastatic non-small cell lung cancer | Phase 2 | IT | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | US | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | BE | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | AU | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | BE | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | IT | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | ES | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | ES | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | US | 01 Feb 2015 | |
metastatic non-small cell lung cancer | Phase 2 | AU | 01 Feb 2015 |
Phase 2 | 82 | Placebo (Placebo/Placebo Arm (Arm 1)) | wkhpcpbgtl(efsitgcjch) = vzwtkudnhg asfprcxzac (gapdarlqcr, aezlrukfxu - tiroflzgvb) View more | - | 20 Aug 2018 | ||
Demcizumab+Placebo (Demcizumab/Placebo Arm (Arm 2)) | wkhpcpbgtl(efsitgcjch) = gvykdwukql asfprcxzac (gapdarlqcr, dacxuniurr - evfiwfronz) View more | ||||||
Phase 2 | 207 | Placebo (Placebo/Placebo Arm) | jhuhztxwmy(dlzcvimeeh): Hazard Ratio (HR) = .930 (95% CI, 0.630 - 1.375), P-Value = 0.7158 | - | 08 Aug 2018 | ||
Demcizumab+Placebo (Demcizumab/Placebo and Demcizumab/Demcizumab) | |||||||
Phase 1 | Non-Small Cell Lung Cancer First line | 46 | pemetrexed+carboplatin+Demcizumab | (ymhitieuso) = vdwkbkuiro vhsxwlhpbr (ivahmazjjc ) View more | Positive | 01 Feb 2018 | |
Phase 2 | Non-squamous non-small cell lung cancer First line | 82 | (rpmwnimuiy) = bamawhpiti rdvdurrzzn (tmclhvmtfu ) View more | Negative | 08 May 2017 | ||
(rpmwnimuiy) = gkzvckqefa rdvdurrzzn (tmclhvmtfu ) View more | |||||||
Phase 1 | Pancreatic Cancer First line | 56 | gemcitabine+demcizumab | (plurjrmzmy) = DEM was limited to 70 days in cohorts 4, 5, 6 & 7. cmnhbnjuly (vocxjetjks ) View more | Positive | 01 Feb 2016 | |
Phase 1 | 57 | (fknhesdddk) = wxcldtkgla detbkqojdv (ptkwovfqdv ) | - | 20 Jan 2014 |