Drug Type Small molecule drug |
Synonyms WX 390, WX-390, WXFL 10030390 + [1] |
Target |
Action inhibitors |
Mechanism PI3K family inhibitors(Phosphatidylinositol 3-kinase family inhibitors), mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationSpecial Review Project (China) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
STK11-mutant cancer | Phase 2 | China | 25 Aug 2023 | |
Uterine Cervix Adenocarcinoma | Phase 2 | China | 01 Aug 2023 | |
Lymphoma | Phase 2 | China | 28 Oct 2022 | |
PIK3CA positive Solid Tumors | Phase 2 | China | 03 Jun 2021 | |
Advanced Malignant Solid Neoplasm | Phase 2 | China | 11 May 2021 | |
Endometrial Carcinoma | Phase 2 | China | 19 Apr 2021 | |
Ovarian Cancer | Phase 2 | China | 19 Apr 2021 | |
Advanced cancer | Phase 1 | China | 25 Oct 2018 | |
PIK3CA mutation/HR-positive/HER2-negative Breast Cancer | IND Approval | China | 17 Mar 2023 | |
Lipomatosis | Preclinical | China | 01 Aug 2024 |
Phase 1/2 | Advanced Cervical Carcinoma PIK3CA mutation status | 49 | WX390 + Toripalimab | chmdeuuspd(rmywncpqop) = jcekiznrvr xbwbyqgema (bdhhrvntpx ) View more | Positive | 28 Apr 2025 | |
(CPI-naive subjects) | chmdeuuspd(rmywncpqop) = vvpdsyigij xbwbyqgema (bdhhrvntpx ) View more | ||||||
NCT06117566 (ESMO2024) Manual | Phase 1/2 | Advanced Cervical Carcinoma Second line | 24 | hcirkgfytd(kpdhrwayoh) = ydtpxpnhqi plhisawrgp (sowpqmkezg ) View more | Positive | 14 Sep 2024 | |
NCT06117566 (ESMO2024) Manual | Phase 1/2 | 65 | cfkgzvpkfu(ajzwkewtzz) = ozswzznqij infsaglgbw (cdlmipddtj ) View more | Positive | 14 Sep 2024 | ||
dtvxyqzxlv(mduypfnyye) = ahhpuzqdnm sflhcqdapl (gyrxfhcfxf ) View more | |||||||
NCT06117540 (ESMO2024) Manual | Phase 2 | Neoplasms ARID1A Mutation | PIK3CA Mutation | 17 | gqhhawxqix(pgankpxvoj) = dzcwlnetom qqcelzunxy (hamiplfnow ) View more | Positive | 14 Sep 2024 | |
WX390bo | gqhhawxqix(pgankpxvoj) = kdfokbnfjh qqcelzunxy (hamiplfnow ) View more | ||||||
Phase 1 | Solid tumor Treg | 18 | hjjnxvyotl(rtwplvudvj) = nonqzemkgb irsycxlmho (gojpnwmgqe, 2.53 - 6.37) | Positive | 24 May 2024 | ||
Phase 1 | 25 | kmxmmfikox(bowrcxybvl) = cuwdcvnzbu dfsggfqeoq (bjuxanqnyd ) View more | Positive | 20 May 2021 |