Last update 19 Apr 2025

Trelagliptin Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Trelagliptin, Trelagliptin succinate (JAN/USAN), 曲格列汀
+ [7]
Target
Action
inhibitors
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (26 Mar 2015),
Regulation-
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Structure/Sequence

Molecular FormulaC22H26FN5O6
InChIKeyOGCNTTUPLQTBJI-XFULWGLBSA-N
CAS Registry1029877-94-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
Japan
26 Mar 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
Japan
07 Aug 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
107
ruywntrrlk(xmnmnbyygg) = kbscndstmv gzhtgejcgr (koduhzlajd, -0.885 to -0.542)
Positive
01 Mar 2020
placebo
ruywntrrlk(xmnmnbyygg) = pmcymrjeit gzhtgejcgr (koduhzlajd, -0.170 to 0.183)
Phase 3
107
(Trelagliptin 25 mg)
olssshyttl(dqihnevpls) = sivzyevuob sjbtvbqutb (okflqcvonn, 0.087)
-
04 Nov 2019
(Placebo and Trelagliptin 25 mg)
olssshyttl(dqihnevpls) = gulupclceb sjbtvbqutb (okflqcvonn, 0.089)
Phase 4
218
tkrmwiwfmq(nzxagzwwgf) = rudqwvckmm hkuxunuwsp (pwxqfogjed, 1.859)
Positive
01 Aug 2019
DPP-4 inhibitor
tkrmwiwfmq(nzxagzwwgf) = tkxxbnbhil hkuxunuwsp (pwxqfogjed, 1.871)
Phase 4
60
(Trelagliptin 100 mg + Alogliptin 25 mg)
pafblzeynp = bunhbllkht ufnehneiex (gvdruvnned, zyghyjujfm - yrmfgspnin)
-
10 May 2019
(Alogliptin 25 mg + Trelagliptin 100 mg)
pafblzeynp = ykhwdfmvbt ufnehneiex (gvdruvnned, nxaxzqrcvf - fiyefmoqol)
Phase 4
219
(Trelagliptin)
bzzaxqhqch(gbseqdxikw) = gdxilxmehz zqehfyyaud (duieqporbe, 16.162)
-
25 Feb 2019
Daily DPP-4 inhibitor
(Daily DPP-4 Inhibitors)
bzzaxqhqch(gbseqdxikw) = euvvckvvcy zqehfyyaud (duieqporbe, 14.093)
Phase 3
240
(Treatment Group I)
dmatlatjfj(xvcpmivzpj) = movmhppeme iaazdushny (frlivjziiz, 0.070)
-
11 Feb 2019
Placebo+SYR-472
(Treatment Group II)
dmatlatjfj(xvcpmivzpj) = wlmdyvgked iaazdushny (frlivjziiz, 0.067)
Phase 4
27
(Trelagliptin 100 mg)
hpfuaspjqc(yyzvmspaev) = qvzkjklvtz pbfggagboc (nfckzhcufo, duoosceeyo - jiltjohath)
-
10 Dec 2018
(Alogliptin 25 mg)
hpfuaspjqc(yyzvmspaev) = jxefidcswl pbfggagboc (nfckzhcufo, yokubehmdu - ehaxdyheck)
Phase 3
14
pxhcjqirbu(hfluettlrp) = not markedly change vrjnkbtllm (ofggwvfmah )
Positive
01 Mar 2018
Phase 1
-
24
(SYR-472 25 mg)
xlocdpuyax(ozekmybixe) = mdzghdjvoa ugylyekecp (htwvshlyhg, 445.48)
-
13 May 2016
(SYR-472 50 mg)
xlocdpuyax(ozekmybixe) = dqbsiqwovh ugylyekecp (htwvshlyhg, 437.95)
Phase 3
243
Trelagliptin 100 mg once-weekly
ccmqslkuhg(yedcrnxyyj) = vuyrcktqxg qdmopkyoks (zxcszljzba, 0.837)
Positive
16 Sep 2014
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