Last update 26 Sep 2026

GKL-006

Overview

Basic Info

Drug Type
iNKT cell therapy, CAR-NKT
Synonyms
GKL 006, GKL-006, GKL006
Target
GPC3
Action
inhibitors
Mechanism
GPC3 inhibitors(Glypican-3 inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease+ [2]
Active Indication
Unresectable Hepatocellular CarcinomaMetastatic Pancreatic Ductal AdenocarcinomaPancreatic Ductal Adenocarcinoma+ [2]
Inactive Indication-
Originator Organization
Beijing Gene Key Life Technology Co., LtdBeijing Gene Key Life Technology Co., Ltd
Active Organization
Beijing Gene Key Life Technology Co., LtdBeijing Gene Key Life Technology Co., Ltd
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Related

5
Clinical Trials associated with GKL-006
NCT07209813
/ RecruitingPhase 2
A Multicenter, Randomized, Open-Label, Controlled Phase 2 Study of GKL-006 Injection in Combination With Transarterial Chemoembolization (TACE) Versus TACE Alone in Patients With Unresectable Hepatocellular Carcinoma
NCT07777211
/ Active, not recruitingPhase 1/2
A Phase I/IIa Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of GKL-006 Injection in Patients With Advanced Pancreatic Cancer
NCT07713290
/ Active, not recruitingPhase 1
An Open-Label, Multiple-Dose Phase 1b Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GKL-006 Injection in Patients With Unresectable Hepatocellular Carcinoma
100 Clinical Results associated with GKL-006
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100 Translational Medicine associated with GKL-006
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100 Patents (Medical) associated with GKL-006
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100 Deals associated with GKL-006
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Unresectable Hepatocellular CarcinomaPhase 2
China
Beijing Gene Key Life Technology Co., LtdBeijing Gene Key Life Technology Co., Ltd
10 Sep 2025
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
China
Beijing Gene Key Life Technology Co., LtdBeijing Gene Key Life Technology Co., Ltd
14 Aug 2025
Pancreatic Ductal AdenocarcinomaPhase 2
China
Beijing Gene Key Life Technology Co., LtdBeijing Gene Key Life Technology Co., Ltd
04 Aug 2025
PsoriasisIND Approval
China
Beijing Gene Key Life Technology Co., LtdBeijing Gene Key Life Technology Co., Ltd
12 Feb 2026
Hepatocellular CarcinomaIND Approval
China
Beijing Gene Key Life Technology Co., LtdBeijing Gene Key Life Technology Co., Ltd
22 Aug 2024
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Clinical Result

Indication
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Evaluation
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Clinical Trial

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Approval

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Regulation

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