Delving into the Latest Updates on Beijing Gene Key Life Technology Co., Ltd with Synapse

Overview

Tags

Digestive System Disorders

Neoplasms

Fusion protein

iNKT cell therapy

CAR-NKT

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

iNKT cell therapy	1
CAR-NKT	1
Fusion protein	1

Top 5 Target	Count

GPC3(Glypican-3)	1
GPC3 x IL-15	1

To evaluate the safety and tolerability of a single dose of GKL-006 injection combined with TACE in patients with unresectable hepatocellular carcinoma, to determine the maximum tolerated dose (MTD) of the combination regimen, and to evaluate the dose-limiting toxicity (DLT) of single-dose treatment.

Start Date06 Apr 2024

Sponsor / Collaborator

Beijing Gene Key Life Technology Co., Ltd

NCT05962450 / RecruitingPhase 2IIT

An Open Label, Randomized, Controlled, Clinical Trial of Adoptive Autologous Invariant Natural Killer T Cells for the Treatment of Progressed Hepatocellular Carcinoma Continuing on PD-1 Inhibitor Therapy

The goal of this clinical trial is to explore the efficacy and safety of autologous iNKT cells in patients with progressed hepatocellular carcinoma (HCC) after treatment with PD-1 antibody. The main question it aims to answer are:
the efficacy of autologous iNKT cells in patients with progressed HCC after treatment with PD-1 antibody.
the safety of autologous iNKT cells in patients with progressed HCC after treatment with PD-1 antibody.
Participants will be randomized 1:1 to receive Regorafenib + PD-1 + iNKT cells (RPI group) or the treatment of Regorafenib + PD-1 (RP group).
Researchers will compare RPI group and RP group to see whether the iNKT cells can achieve a better therapeutic effect on HCC patients with PD-1 resistance.

Start Date26 Oct 2023

Sponsor / Collaborator

Beijing YouAn Hospital

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100 Clinical Results associated with Beijing Gene Key Life Technology Co., Ltd

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0 Patents (Medical) associated with Beijing Gene Key Life Technology Co., Ltd

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100 Deals associated with Beijing Gene Key Life Technology Co., Ltd

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100 Translational Medicine associated with Beijing Gene Key Life Technology Co., Ltd

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Pipeline

Pipeline Snapshot as of 25 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Phase 1

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