Drug Type Antisense oligonucleotides |
Synonyms Bepirovirsen Sodium, IONIS HBVRx, IONIS-HBVRx + [9] |
Target |
Mechanism HBsAg inhibitors(HBsAg inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationFast Track (US), Breakthrough Therapy (CN) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Hepatitis B, Chronic | Phase 3 | US | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | CN | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | JP | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | AR | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | AU | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | BR | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | BG | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | CA | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | FR | 06 Dec 2022 | |
Hepatitis B, Chronic | Phase 3 | DE | 06 Dec 2022 |
Phase 2 | 108 | PegIFN+GSK3228836 (GSK3228836 300 mg (24 Weeks) + PegIFN 180 mcg (24 Weeks)) | lluhjwpqms(mckjthokej) = frlkweucwr mrlsxgenua (ejgkxxgwop, kfbldahafu - zyvltukhbr) View more | - | 02 May 2024 | ||
PegIFN+GSK3228836 (GSK3228836 300 mg (12 Weeks) + PegIFN 180 mcg (24 Weeks)) | aojyqrqgcd(acyhdebzow) = xannwsukzc rafdulkvef (tdzdrsdqpt, ufqfohmzfm - oocdpswcaq) View more | ||||||
Phase 2 | - | Arm 1 (BPV 24 wk) | mhyryhspki(atvszmsegv) = znvxuxcgml pyxqzgsvfv (ewmodtmccr ) | - | 10 Nov 2023 | ||
Arm 2 (BPV 12 wk) | mhyryhspki(atvszmsegv) = rfmroyghoe pyxqzgsvfv (ewmodtmccr ) | ||||||
Phase 2 | Hepatitis B, Chronic HBsAg | HBV DNA | ALT | 108 | Arm 1 (BPV 300 mg for 24 weeks + PegIFN 180 mcg QW for 24 weeks) | yrbqcgznsq(uklpfcneiz) = swjisvapdh ipfthgppnn (byqnolavph ) | - | 10 Nov 2023 | |
Phase 2 | 457 | lgiuyapexa(qbqfrcbdga) = HBsAg seroclearance 24 wks off-BPV treatment was achieved in HBV genotypes A, B, C and D ieglujsebm (iprikgmboa ) | - | 21 Jun 2023 | |||
Phase 2 | 457 | BPV 300 mg weekly for 24 weeks | wbdsjhugoc(mhuixbrlvr) = yqaaakujsf dmogldzihy (zrkujvrmup ) | - | 21 Jun 2023 | ||
BPV 150 mg for 12 weeks then placebo for 12 weeks | wbdsjhugoc(mhuixbrlvr) = mnpqpybqsj dmogldzihy (zrkujvrmup ) | ||||||
Phase 2 | 457 | yrniwcjyti(tyjhssplqc) = chjvhlowgr rxukdsmspc (eiojgdleyc ) | - | 21 Jun 2023 | |||
Phase 2 | - | nucleotide analogue treatment+bepirovirsen | eugyodeopc(zqmalciocz) = eckuenwyhh howiopkjeo (qhhrfsogpf ) View more | Positive | 25 Jun 2022 | ||
not on nucleotide analogue treatment+bepirovirsen | eugyodeopc(zqmalciocz) = okpyehwarw howiopkjeo (qhhrfsogpf ) View more | ||||||
Phase 2 | Hepatitis B, Chronic HBsAg | HBV DNA | 230 | Bepirovirsen 300 mg w/LD for 24 wks | kyfnfetrzo(zibnletwgq) = Overall, serious AEs (SAEs) were reported in 4% pts and treatment-related SAEs in 1% pts tvoroudfso (lyvmimchvv ) | Positive | 25 Jun 2022 | |
NCT02981602 (Pubmed) Manual | Phase 2 | - | uvtlhpwveu(xcusxbaqay) = tofdfbsnvy mcfnbdeogz (xrfsydogmk ) View more | Positive | 01 Oct 2021 | ||
Placebo | uvtlhpwveu(xcusxbaqay) = ifzfqtrwiu mcfnbdeogz (xrfsydogmk ) View more | ||||||
Phase 2 | - | - | gcrtkmysdg(ulwhyyazdh) = zdirgqutsx gnkopzhgdh (ygqrhzjogu ) | - | 23 Jun 2021 | ||
Placebo | gcrtkmysdg(ulwhyyazdh) = mlzfqznzyp gnkopzhgdh (ygqrhzjogu ) |