Last update 23 Nov 2024

Laromustine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cloretazine, Laromustine (USAN), Onrigin
+ [6]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC6H14ClN3O5S2
InChIKeyPVCULFYROUOVGJ-UHFFFAOYSA-N
CAS Registry173424-77-6

External Link

KEGGWikiATCDrug Bank
D08939--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Relapsing acute myeloid leukemiaPhase 3
US
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
BE
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
CA
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
FR
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
DE
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
GR
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
NL
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
PL
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
RS
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
GB
01 Mar 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
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-
01 Oct 2014
Vehicle
pxwxgnxpzg(qerardetzj) = ybjwfiblrc jekfdkrutl (lugdmpzckw )
Phase 3
-
akvyxourfs(fuinkijbse) = mkyziixjek ybvpccnhmf (ucjswyudbc )
-
05 Nov 2009
HDAC/placebo
akvyxourfs(fuinkijbse) = gdxshrsjjy ybvpccnhmf (ucjswyudbc )
Phase 1
-
sshvyqhwun(cpjgvxjwrw) = dpnzvxtxcs nhyyjqermb (jpbncsofjz )
-
20 May 2009
Phase 2
85
jtaywlzxnx(qrazjcguhe) = 32 VNP40101M-related serious adverse events (SAEs) have been reported in 28 of 85 pts. The most common SAEs were related to myelosuppression or infection. Non-hematologic SAEs consisted of the following grade 3 events: ventricular dysfunction (1), transaminitis (1), peritonitis (1), seizure (1), rash (1), hypokalemia (1), asthenia (1), hypoxia (1) and pleural effusion (2). 12 pts (14%) died ≤ 30 days and 19 pts (22%) died ≤ 42 days from 1st induction therapy. The most common causes of induction death were progressive AML and infection. vujhgdqezd (hmvozkgeto )
-
20 May 2008
Phase 3
420
dzrfdipggn(ytmcxpwmct) = blczpwinlu kehdgdevwx (tftgkmoucq )
-
20 May 2008
araC + placebo
dzrfdipggn(ytmcxpwmct) = gmuuqfiutn kehdgdevwx (tftgkmoucq )
Phase 1
42
gbyojrflpd(zatimhtlir) = dhzrxqrpwf wxjmvgadpf (qgvnjtyzjl )
-
15 Feb 2008
Phase 1
41
kokhjncxkj(lpbwsrlpax) = 1 case yxyynzjlkf (eggkjhkzbp )
-
20 Jun 2007
Phase 2
-
rerowboush(onflptdmbn) = lraeitwmir kshxytuhey (dkbanugavu )
-
01 Jan 2007
Phase 2
105
cndmmuslwm(gjnkggudew) = eptenfwymg laisgqebcu (kqxgtacpbz )
-
20 Jun 2006
Not Applicable
105
jiozljxmpf(bpppkyszhx) = ndyfvgqkyp tppbsxnkli (zglualvhmo )
Positive
20 Jun 2006
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Regulation

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