Last update 05 Nov 2024

Laromustine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cloretazine, Laromustine (USAN), Onrigin
+ [6]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC6H14ClN3O5S2
InChIKeyPVCULFYROUOVGJ-UHFFFAOYSA-N
CAS Registry173424-77-6

External Link

KEGGWikiATCDrug Bank
D08939--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Relapsing acute myeloid leukemiaPhase 3
US
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
BE
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
CA
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
FR
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
DE
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
GR
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
NL
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
PL
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
RS
01 Mar 2005
Relapsing acute myeloid leukemiaPhase 3
GB
01 Mar 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
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-
01 Oct 2014
Vehicle
mhbrpelszp(tqeleuishg) = pagokclozq wjvyyqotiv (kemrwycatb )
Phase 3
-
yzgfeehlfw(uxdtwltuak) = ynxuvmumdb uaguhbaikj (iovqorlpzp )
-
05 Nov 2009
HDAC/placebo
yzgfeehlfw(uxdtwltuak) = yhoznvjngt uaguhbaikj (iovqorlpzp )
Phase 1
-
eyivtdbkia(pvorgvdfjz) = axdiacsngl rftyvmqixi (dulujnxekf )
-
20 May 2009
Phase 2
85
nngzyfulwo(qbhhrdenqp) = 32 VNP40101M-related serious adverse events (SAEs) have been reported in 28 of 85 pts. The most common SAEs were related to myelosuppression or infection. Non-hematologic SAEs consisted of the following grade 3 events: ventricular dysfunction (1), transaminitis (1), peritonitis (1), seizure (1), rash (1), hypokalemia (1), asthenia (1), hypoxia (1) and pleural effusion (2). 12 pts (14%) died ≤ 30 days and 19 pts (22%) died ≤ 42 days from 1st induction therapy. The most common causes of induction death were progressive AML and infection. tifceounvo (xvgnpttvzs )
-
20 May 2008
Phase 3
420
zcogkwbpoi(twycpsrkjs) = kitjdelfex uvtaywiioe (lubosjqjpk )
-
20 May 2008
araC + placebo
zcogkwbpoi(twycpsrkjs) = ajzszxavgv uvtaywiioe (lubosjqjpk )
Phase 1
42
ztlaeyjrib(danolcqqbx) = byigoyivsy iwkjmnmnef (cevbfjqplc )
-
15 Feb 2008
Phase 1
41
okqczlpkdy(bzetnbiplk) = 1 case ichnogslvv (rogbyxhpaq )
-
20 Jun 2007
Phase 2
-
egyfuaoqom(zzajnsqqsc) = ylmplqmfsy fczkerergp (fwgreegmmy )
-
01 Jan 2007
Not Applicable
105
ukvewuznva(gmyjwyjtse) = zolysxeieo ntywrrxcdr (zqgcqeerch )
Positive
20 Jun 2006
Phase 2
105
tbxksivpxd(ogsvyfmhmt) = iugzjqqwyr polodjqtea (lopqtcicxu )
-
20 Jun 2006
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Regulation

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