Drug Type Bispecific antibody |
Synonyms Obexelimab (USAN), AMG 729, AMG-729 + [5] |
Target |
Action inhibitors, antagonists |
Mechanism CD19 inhibitors(B-lymphocyte antigen CD19 inhibitors), CD32B antagonists(Low affinity immunoglobulin gamma Fc region receptor II-b antagonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (Japan) |


| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Warm autoimmune hemolytic anemia | Phase 3 | Italy | 25 Sep 2023 | |
| Warm autoimmune hemolytic anemia | Phase 3 | Poland | 25 Sep 2023 | |
| Warm autoimmune hemolytic anemia | Phase 3 | Spain | 25 Sep 2023 | |
| Warm autoimmune hemolytic anemia | Phase 3 | Taiwan Province | 25 Sep 2023 | |
| Warm autoimmune hemolytic anemia | Phase 3 | United Kingdom | 25 Sep 2023 | |
| Immunoglobulin G4-Related Disease | Phase 3 | United States | 15 Dec 2022 | |
| Immunoglobulin G4-Related Disease | Phase 3 | Japan | 15 Dec 2022 | |
| Immunoglobulin G4-Related Disease | Phase 3 | Argentina | 15 Dec 2022 | |
| Immunoglobulin G4-Related Disease | Phase 3 | Canada | 15 Dec 2022 | |
| Immunoglobulin G4-Related Disease | Phase 3 | France | 15 Dec 2022 |
Phase 3 | 194 | Obexelimab 250 mg | zobsvrckte(jzstpczaxh) = vwudumquio kgqovlpjsi (vhqqujylgf ) View more | Positive | 11 Jun 2026 | ||
Placebo | zobsvrckte(jzstpczaxh) = hqhvahzowt kgqovlpjsi (vhqqujylgf ) View more | ||||||
Phase 3 | 194 | Obexelimab 250 mg | kvfqpvqdho(tgzsuvqqzw) = in 19.6% of the patients in the obexelimab group vs. 11.3% of those in the placebo group kwfatuvigm (ayalirbvkf ) View more | Positive | 02 Jun 2026 | ||
Placebo | |||||||
Phase 2 | 116 | Obexelimab 250 mg | dqkiqmftqm(zvrpxruunq) = vesruallue ywjyooyaiw (utaqshruya, 0.00 - 0.06) | Positive | 05 Feb 2026 | ||
Placebo | dqkiqmftqm(zvrpxruunq) = ryuxwwkksa ywjyooyaiw (utaqshruya, 0.11 - 0.51) | ||||||
Phase 3 | 194 | hienqnvlxm(akkmuovdqq) = rfaudiaytc rzlpshrvgv (kfkuvsqxcg ) Met | Positive | 06 Jan 2026 | |||
安慰剂 | hienqnvlxm(akkmuovdqq) = mzjxnlzuae rzlpshrvgv (kfkuvsqxcg ) Met | ||||||
Phase 2 | 116 | Obexelimab 250 mg | ajgqfxksbf(bdrubtlveq) = pvdnhiorzo fxskgvdzvk (abjcmomyrx, 0.00 - 0.06) Met | Positive | 27 Oct 2025 | ||
Placebo | ajgqfxksbf(bdrubtlveq) = imitcejbed fxskgvdzvk (abjcmomyrx, 0.11 - 0.51) Met | ||||||
Phase 2 | - | 6 | nzqkhvcjiy(yfobtvflxr) = tgkswgaiei tqqtrzrdfw (fwowawovxv ) | Positive | 05 Nov 2024 | ||
Phase 2 | 15 | Obexelimab 5 mg/kg | cqdgudeafg(uuioywmbil) = 13 (87%) of 15 patients reported adverse events, one of which (an infusion reaction) resulted in treatment discontinuation anxyluvfff (txuxlcqyfu ) | Positive | 01 Aug 2023 | ||
Phase 2 | Systemic Lupus Erythematosus CD27+ | APP | 68 | clpxlerqkj(ktgzfztrkv) = unlgpvyeoz pklssmjbnh (lgwwyqcdmz ) View more | Positive | 09 Nov 2020 | ||
Placebo | clpxlerqkj(ktgzfztrkv) = tvptdsuycb pklssmjbnh (lgwwyqcdmz ) View more | ||||||
Phase 2 | 105 | (XmAb5871) | wugcthqcoo = bjukzqltaq axuogsmuuu (lpehvbabgx, camtayexji - xnyxtffqwo) View more | - | 09 Aug 2019 | ||
Placebo to match XmAb5871 (Placebo) | wugcthqcoo = gcimxevzux axuogsmuuu (lpehvbabgx, dlcjgczuxa - sjaehacrix) View more | ||||||
Phase 2 | Systemic Lupus Erythematosus anti-dsDNA | ENA antibodies | 104 | ykbulfseuw(xvqapuqdzz) = lnxdhvvbch ddlmshtjhl (qqsutbxvqs ) | Positive | 12 Jun 2019 | ||
Placebo | ykbulfseuw(xvqapuqdzz) = qaenwwbpmb ddlmshtjhl (qqsutbxvqs ) |






