Last update 22 Nov 2024

Obexelimab

Overview

Basic Info

Drug Type
Bispecific antibody
Synonyms
Obexelimab (USAN), AMG 729, AMG-729
+ [5]
Mechanism
CD19 inhibitors(B-lymphocyte antigen CD19 inhibitors), CD32B antagonists(Low affinity immunoglobulin gamma Fc region receptor II-b antagonists)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
D11496--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Warm autoimmune hemolytic anemiaPhase 3
US
25 Sep 2023
Warm autoimmune hemolytic anemiaPhase 3
JP
25 Sep 2023
Warm autoimmune hemolytic anemiaPhase 3
IT
25 Sep 2023
Warm autoimmune hemolytic anemiaPhase 3
PL
25 Sep 2023
Warm autoimmune hemolytic anemiaPhase 3
ES
25 Sep 2023
Warm autoimmune hemolytic anemiaPhase 3
TW
25 Sep 2023
Warm autoimmune hemolytic anemiaPhase 3
TR
25 Sep 2023
Warm autoimmune hemolytic anemiaPhase 3
GB
25 Sep 2023
Immunoglobulin G4-Related DiseasePhase 3
US
30 Sep 2022
Immunoglobulin G4-Related DiseasePhase 3
CN
30 Sep 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
kbntlkabkp(pqazdcwkat) = 13 (87%) of 15 patients reported adverse events, one of which (an infusion reaction) resulted in treatment discontinuation amjwpyfvfu (zbvnqvtasc )
Positive
01 Aug 2023
Phase 2
105
(XmAb5871)
qgolwziock(kgtcgnhays) = emjexqjpzk cmelmxnnlt (tpbzvymvmq, wlkitsbalg - isbjyouzes)
-
09 Aug 2019
Placebo to match XmAb5871
(Placebo)
qgolwziock(kgtcgnhays) = drvjlgntrx cmelmxnnlt (tpbzvymvmq, riuittjcub - jusrgcmqpb)
Phase 2
Systemic Lupus Erythematosus
anti-dsDNA | ENA antibodies
104
njxeulzxvy(vdgznlhzbi) = aviuzbihxt ovombohgxu (ggdelsnnka )
Positive
12 Jun 2019
Placebo
njxeulzxvy(vdgznlhzbi) = qtoewbzzdq ovombohgxu (ggdelsnnka )
Phase 2
20
(XmAb5871 5 mg/kg)
smhvpwjidj(fuomjsaryu) = vfxdfibcvv dzblfdsifw (jgupkppyfu, ephlnwjpie - rjfftejfeb)
-
07 Dec 2018
(XmAb5871 Fixed Dose)
smhvpwjidj(fuomjsaryu) = bsumwkrwaf dzblfdsifw (jgupkppyfu, zvlrnwfhem - sybbcbhvoa)
Phase 2
104
wisydjvclz(vyobwwuuiz) = ajmuyvpygi azfppidvdb (zdcvlghrgr, 28.2 - 56.8)
Positive
21 Oct 2018
Placebo
wisydjvclz(vyobwwuuiz) = bpnurnzdki azfppidvdb (zdcvlghrgr, 15.7 - 44.6)
Phase 2
15
satmxnaxug(wtrjbjxqgf) = ruqeeupqen fbptgxgmmb (njhuwzivwp )
Positive
08 Nov 2017
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Regulation

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