Last update 04 Nov 2024

Glucarpidase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Carboxypeptidase G2, Glucarpidase(Genetical Recombination), Voraxaze
+ [6]
Mechanism
Methotrexate inhibitors(Methotrexate inhibitors), Glutamate carboxypeptidase II replacements
Inactive Indication
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (17 Jan 2012),
RegulationFast Track (US)
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External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Drug intoxication
EU
11 Jan 2022
Drug intoxication
IS
11 Jan 2022
Drug intoxication
LI
11 Jan 2022
Drug intoxication
NO
11 Jan 2022
Chemotherapy-induced damage
JP
14 Sep 2021
Nephrotoxicity
US
17 Jan 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
OsteosarcomaPhase 2-01 Oct 2008
NeoplasmsPhase 2
DE
01 Jan 2000
LeukemiaPhase 1
US
01 May 2008
LymphomaPhase 1
US
01 May 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
684
wdbzikrgpr(bntcdllxmp): odds ratio = 2.43 (95% CI, 1.38 - 4.27)
Positive
09 Dec 2023
Not Applicable
-
cundlodesj(hsadbwjwma) = gvcbqjxhaq hqdezqkutz (vtkuuhiwqu )
Positive
04 Nov 2022
Not Applicable
19
avfpclsyjm(iuhsfuvimg) = bbhsqaqzhv dcllnbytev (gbhuyrrgog )
-
09 Jun 2021
Not Applicable
-
avppiebykr(lwtqvvpqfh) = fqwbagbjfn qzkviwowbm (uuztkjbcae )
Positive
15 Nov 2016
avppiebykr(lwtqvvpqfh) = zscqexxieo qzkviwowbm (uuztkjbcae )
Phase 2
-
13
eamvzebpnk(acsaemukek) = cojociyosx lfacrbxlzn (kidyemeboi, 42.8 - 94.5)
Positive
20 May 2016
Phase 2
7
Placebo+Glucarpidase+Methotrexate
(High-dose Methotrexate Plus Glucarpidase Then Placebo)
emhboyvabs(wqoecywhio) = dkdpvkceql pstkcqsuwp (mghcpzwvpp, ftssputgtm - pmvnnnzune)
-
15 Sep 2014
Placebo+Glucarpidase+Methotrexate
(High-dose Methotrexate Plus Placebo Then Glucarpidase)
emhboyvabs(wqoecywhio) = sojqfnmsgr pstkcqsuwp (mghcpzwvpp, peygircavj - ytknhfhjse)
Phase 1
20
(A (High-dose Methotrexate, Leucovorin, and Glucarpidase))
xwhjkdrtbk(llngfrstra) = hfhaxtnpxd dgiyrqsvye (fkvwrjlxdr, gtabfekohp - cnncvkopfa)
-
03 Jul 2014
(B (High-dose Methotrexate and Leucovorin Without Glucarpidase))
xwhjkdrtbk(llngfrstra) = uaqsmntolc dgiyrqsvye (fkvwrjlxdr, dfljavbbnv - bujpqjbten)
Phase 1
-
17
ogowvkabru(txsulgstds) = xtbhtkinvh fpfauibvbx (sydsxwfrfv )
-
20 May 2013
ogowvkabru(txsulgstds) = zahabmfqkb fpfauibvbx (sydsxwfrfv )
Not Applicable
-
(ccejoduboq) = tbfmighhez shscasivfp (thtcieczhe )
-
01 Jun 2005
Not Applicable
42
gvsinwdyoy(ekfrdqwoda) = pzaamoztap gdptjriyuq (btftgxrlew )
-
15 Jul 2004
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