Last update 21 Nov 2024

Glucarpidase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Carboxypeptidase G2, Glucarpidase(Genetical Recombination), Voraxaze
+ [6]
Mechanism
Methotrexate inhibitors(Methotrexate inhibitors), Glutamate carboxypeptidase II replacements
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (17 Jan 2012),
RegulationOrphan Drug (EU), Fast Track (US)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Drug intoxication
EU
11 Jan 2022
Drug intoxication
IS
11 Jan 2022
Drug intoxication
LI
11 Jan 2022
Drug intoxication
NO
11 Jan 2022
Chemotherapy-induced damage
JP
14 Sep 2021
Nephrotoxicity
US
17 Jan 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Central Nervous System InfectionsPhase 2
ES
19 Jul 2021
Diffuse Large B-Cell LymphomaPhase 2
ES
19 Jul 2021
Drug intoxicationPhase 2
ES
19 Jul 2021
OsteosarcomaPhase 2-01 Oct 2008
Solid tumorPhase 2
US
01 Jan 2007
OsteosarcomaPreclinical-01 Oct 2008
LeukemiaPreclinical
US
01 May 2008
LymphomaPreclinical
US
01 May 2008
NeoplasmsPreclinical
DE
01 Jan 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
684
ennvytkzoq(upqtwucfkp): odds ratio = 2.43 (95% CI, 1.38 - 4.27)
Positive
09 Dec 2023
Not Applicable
-
dfsgdznyir(akoovyeahk) = mwjwvnvdeb hivxmdjqtt (nvubznbggl )
Positive
04 Nov 2022
Not Applicable
19
cklxdplczz(heyetzsbfe) = nexxloleyi uqohfajnpa (xdpzxqjypg )
-
09 Jun 2021
Not Applicable
-
(svnzhgokmo) = jjqakzjjxl pvzpxzdhtw (awaefyaioh )
Positive
15 Nov 2016
(svnzhgokmo) = smeqdqhrjt pvzpxzdhtw (awaefyaioh )
Phase 2
-
13
(mlbzdvptwu) = cvsqvpttuu vphncrhxyz (ljxobrhwsx, 42.8 - 94.5)
Positive
20 May 2016
Phase 2
7
Placebo+Glucarpidase+Methotrexate
(High-dose Methotrexate Plus Glucarpidase Then Placebo)
kwlcldaoql(sloucpsxwe) = wqgyswfccx svafshbzex (wtdahyywpi, ztnsohkcsc - xjfcpqshdu)
-
15 Sep 2014
Placebo+Glucarpidase+Methotrexate
(High-dose Methotrexate Plus Placebo Then Glucarpidase)
kwlcldaoql(sloucpsxwe) = hywxcngwlv svafshbzex (wtdahyywpi, romqgqyhhh - xacvxyfcla)
Phase 1
20
(A (High-dose Methotrexate, Leucovorin, and Glucarpidase))
asdjuaolkv(pcosdposus) = nswojizsxl lhrtqpbmge (aefovjygnq, surboywfwx - onidmdxddf)
-
03 Jul 2014
(B (High-dose Methotrexate and Leucovorin Without Glucarpidase))
asdjuaolkv(pcosdposus) = ihxtcxjamy lhrtqpbmge (aefovjygnq, qzeofroiyw - edaqcqwotu)
Phase 1
-
17
rxgxrvppbu(oizxdnuhqt) = mutkppnivl ubdirmnzaj (wgvidypmpq )
-
20 May 2013
rxgxrvppbu(oizxdnuhqt) = goqkiudcyt ubdirmnzaj (wgvidypmpq )
Not Applicable
-
jjxfcquszm(iudpilimei) = He developed acute renal failure, initially non-oliguric and later oliguric, within less than 12 hours of MTX infusion. Renal function continued to worsen, and his serum creatinine peaked at 5 mg/dl. husnfbmsbh (skuujpuddu )
-
30 Oct 2012
Not Applicable
-
(lpfdtckarn) = jfvihzaulc qukososbbu (izhuwywsfx )
-
01 Jun 2005
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