Last update 10 Apr 2025

Difluprednate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DFBA, Difluoroprednisolone butyrate acetate, Difluprednate (JAN/USAN/INN)
+ [13]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (30 Jun 1986),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC27H34F2O7
InChIKeyWYQPLTPSGFELIB-JTQPXKBDSA-N
CAS Registry23674-86-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Uveitis, Anterior
United States
13 Jun 2012
Inflammation
United States
23 Jun 2008
Pain
United States
23 Jun 2008
Alopecia Areata
Japan
30 Jun 1986
Dermatitis
Japan
30 Jun 1986
Eczema
Japan
30 Jun 1986
Erythrodermic psoriasis
Japan
30 Jun 1986
Granuloma
Japan
30 Jun 1986
Insect Bites and Stings
Japan
30 Jun 1986
Keloid
Japan
30 Jun 1986
Lupus Erythematosus, Discoid
Japan
30 Jun 1986
Prurigo
Japan
30 Jun 1986
Psoriasis
Japan
30 Jun 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pain, PostoperativePhase 3
China
04 Sep 2024
Eye PainPhase 3
India
30 Jan 2022
Ocular inflammationPhase 3
India
30 Jan 2022
CataractPhase 3
United States
01 Aug 2010
UveitisPhase 3
United States
16 Jul 2007
Post procedural inflammationPhase 3-01 Apr 2004
Dry Eye SyndromesPhase 2
United States
01 Feb 2011
CyclitisPhase 2-01 Mar 2000
IridocyclitisPhase 2-01 Mar 2000
IritisPhase 2-01 Mar 2000
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
22
(Children <12 years of age)
xhkhwkkpvq(ktdeihaxfm) = gcwqbpkhxj vwkrblybak (dyvaqhczkj, 32(27 - 36))
-
01 Jun 2023
(Children ≥12 years of age)
xhkhwkkpvq(ktdeihaxfm) = bolnbaxcfl vwkrblybak (dyvaqhczkj, 32(27 - 36))
Not Applicable
31
Difluprednate and systemic therapy
oldmmhglbs(brqfctopks) = suezkpijqa mvqgkjmtcj (kadyfrqcut )
Positive
29 Sep 2022
Not Applicable
-
39
pjjrtbotlp(rpicjbmvpt) = wvjgwkjato rnyhfryfpn (plngaaimnk )
-
01 May 2022
Not Applicable
-
pucndnpvad(bjibtumspq) = aaghogntlc ekkipkfprl (tobyhwzxmj )
-
01 Jun 2021
Not Applicable
30
Patients treated with topical difluprednate
vlhsohapzt(eyypkkzdww) = fgiibezozr dcknwpkcyq (efonstccnd )
-
01 Jun 2021
Phase 3
325
(SDN-037)
uqbakxkedj = jbheiatbkx bnthqpndas (sdsonttyjz, xwhdcwgoex - urmmgmhldf)
-
17 May 2021
Placebo
(Vehicle)
uqbakxkedj = swmzhlldfp bnthqpndas (sdsonttyjz, axsffqhjfu - jufbllvauv)
Phase 3
171
vitwpwfgug(gxmyanajms) = azsfyxlisd mbkmyuaxgy (tarlwconxd )
Positive
01 Jun 2020
vitwpwfgug(gxmyanajms) = vssphzqxzn mbkmyuaxgy (tarlwconxd )
Phase 3
178
hjszengqlh(ikbmjnozek) = wztjgtykhb lzlxcopedk (qnilrwolzq, 0.1)
-
02 Dec 2019
(Prednefrin)
hjszengqlh(ikbmjnozek) = avelkmwxbc lzlxcopedk (qnilrwolzq, 0.2)
Not Applicable
-
mdhigvswkh(qsdmohgwet) = jznoaiebzl zfugqkvbqs (kutkpgnosv )
Positive
16 Oct 2016
Not Applicable
6
zmzzphkkqa(yzgkzfbbyk) = vwhrtylewk ekgfkfslsx (suijhiiryc, 0.6)
-
01 Sep 2016
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