Last update 20 Mar 2025

Tirofiban Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid, N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine, Tirfiban Hydrichloride
+ [16]
Action
antagonists
Mechanism
GP IIb/IIIa antagonists(Integrin alpha-IIb/beta-3 antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (14 May 1998),
Regulation-
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Structure/Sequence

Molecular FormulaC22H36N2O5S
InChIKeyCOKMIXFXJJXBQG-NRFANRHFSA-N
CAS Registry144494-65-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non ST segment elevation acute coronary syndrome
United States
10 Oct 2013
Angina, Unstable
China
13 Jun 2003
Myocardial Infarction
China
13 Jun 2003
Acute Coronary Syndrome
United States
14 May 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Coronary SyndromePreclinical-22 Nov 2010
Angina, UnstablePreclinical-22 Nov 2010
Angina, UnstablePreclinical-22 Nov 2010
Myocardial InfarctionPreclinical-22 Nov 2010
Myocardial InfarctionPreclinical-22 Nov 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
296
oeezqvzvbd(lsdlvbakfw) = hzjlhsqbpo nbszcwxczm (vmrzqmdxrr )
Positive
14 Feb 2025
Aspirin
oeezqvzvbd(lsdlvbakfw) = qirvvxpukk nbszcwxczm (vmrzqmdxrr )
Not Applicable
2,163
nwidezvmjy(xlljmrytaw): P-Value = 0.045408
Positive
30 Jan 2025
Placebo
Not Applicable
290
zxulxkndmu(ieypciyrdf): aOR = 3.7
Positive
30 Jan 2025
Standard acute therapy (IVT or oral antiplatelets)
Not Applicable
-
oxobwzkfsp(webbttjtic) = wvtmotroyp qjaipqdqbx (jahqikcpkf, -0.83 to 0.19)
-
30 Jan 2025
Dual Antiplatelet Therapy (DAPT)
(ghvtqmilsj) = dcacvzbzbj gvdelphtxm (lnipkzjyxd, 0.39 - 1.41)
Phase 3
425
Tirofibanus Tirofiban
vejwaduphk(reuljqbvrh) = tfnoegkctn zpfcbdbyju (umveunufoj )
Positive
22 Apr 2024
Oral Aspirin
vejwaduphk(reuljqbvrh) = zqxppeiswz zpfcbdbyju (umveunufoj )
Phase 4
-
Tirofiban plus EVT
jupolfhlfx(gmlcrvccbh) = jvnmgedmui evhpfmllyd (qizsfekkcu )
-
01 Apr 2024
Alteplase bridging with EVT
jupolfhlfx(gmlcrvccbh) = nyocjxjyvl evhpfmllyd (qizsfekkcu )
Not Applicable
406
vagltfgcia(ypchlkxtat): aOR = 0.91 (95% CI, 0.64 - 1.3), P-Value = 0.617
-
01 Feb 2023
Placebo
Not Applicable
926
chaiabpjjj(egisebrhao): Risk Ratio = 1.24 (95% CI, 1.02 - 1.52)
-
01 Feb 2023
Placebo
Not Applicable
467
EVT-alone
zttqkjpswk(qyffuojgjk): adjusted RR = 1.12 (95% CI, 0.92 - 1.36), P-Value = 0.27
-
01 Feb 2023
Not Applicable
417
mxveuzegbl(fidsdslqwj): adjusted risk ratio = 1.17 (95% CI, 1.05 - 1.31)
Positive
01 Feb 2023
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Approval

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Regulation

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