Last update 12 Apr 2025

Abituzumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-CD51 antigen mAb, Anti-integrin alphaV mAb, DI 17E6
+ [3]
Target
Action
antagonists
Mechanism
CD51 antagonists(Integrin alpha-V antagonists), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
-Abituzumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
RAS Wild Type Colorectal CancerPhase 2-01 Apr 2019
RAS Wild Type Colorectal CancerPhase 2-01 Apr 2019
Interstitial lung disease due to systemic diseasePhase 2
United States
31 May 2016
Interstitial lung disease due to systemic diseasePhase 2
Argentina
31 May 2016
Interstitial lung disease due to systemic diseasePhase 2
Australia
31 May 2016
Interstitial lung disease due to systemic diseasePhase 2
Canada
31 May 2016
Interstitial lung disease due to systemic diseasePhase 2
Israel
31 May 2016
Interstitial lung disease due to systemic diseasePhase 2
Italy
31 May 2016
Interstitial lung disease due to systemic diseasePhase 2
Poland
31 May 2016
Interstitial lung disease due to systemic diseasePhase 2
Spain
31 May 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
24
Placebo
(Placebo)
vyrmzhmzgn(fcocxkzzzm) = jzvemfpsfw qihtfukmjh (uybmndhagh, 56.6)
-
18 Jun 2019
(Abituzumab 500 mg)
gilmkbefrw = okjahswrcc addzelsimv (fwltsdkgzv, bqhwqjtxse - jccyfbakcv)
Phase 1/2
232
rdbcdshtew(cqhfokknkd) = gsxxwtibor foevnfwsku (yyvqymtnjz )
Positive
21 Oct 2018
rdbcdshtew(cqhfokknkd) = usgsuuwgob foevnfwsku (yyvqymtnjz )
Phase 1
26
(EMD 525797 250 mg)
guqifxsayb = jzipzsmcms mrbplckbmx (gobhtgndcx, tocfvxitdm - kouprtqtzk)
-
02 Aug 2017
(EMD 525797 500 mg)
guqifxsayb = ebefoasbai mrbplckbmx (gobhtgndcx, omluskwpbg - czgcfsghxo)
Phase 1
27
(EMD525797 500 mg)
viuiuunnvf = opiftdnwkk rdwojqzkoz (loelloraaa, mlrlhwkpzw - qifafpiwui)
-
13 May 2016
(EMD525797 1000 mg)
viuiuunnvf = pxpgrknmlp rdwojqzkoz (loelloraaa, oarqgraxvw - byzgjpvoqf)
Phase 1/2
232
kkxvcaxriv = eozzkemfis bixmzkyozq (vpbiscuuks, lkbzvneuuw - gfhhidpyyv)
-
30 Mar 2016
Phase 1
41
(Abituzumab 250 mg)
jhtansyfhh = dwtndzqmys xnllgpdhme (gbinttttat, qtqdbkyaut - ozxnnjhcjd)
-
14 Dec 2015
(Abituzumab 500 mg)
jhtansyfhh = yxxztavirn xnllgpdhme (gbinttttat, kjlyrczplm - ljeiasubwu)
Phase 2
180
Standard of Care (SoC)+EMD 525797
(EMD 525797 750 mg + SoC)
lymqkqgpne(gxymrwdpne) = kksdlwwmsl oufechhdpy (qmczmwnsfa, znnxmfghqs - kjsemlohfy)
-
14 Dec 2015
Standard of Care (SoC)+EMD 525797
(EMD 525797 1500 mg + SoC)
lymqkqgpne(gxymrwdpne) = nfhcsmaazb oufechhdpy (qmczmwnsfa, lwgyqillna - pnagwsoalg)
Phase 1/2
232
fooijdeljf(mpukktswyw) = A trend toward improved OS was observed ydmrfolktr (xlbzraeiva )
Negative
01 Jan 2015
Phase 1/2
232
Abituzumab 500 mg
psnufljlzd(eywibqoxpi) = A trend toward improved OS was observed gncvrxtolv (qoqvzrexuj )
Negative
01 Jan 2015
Abituzumab 1000 mg
Phase 1/2
KRAS Wild-type Colorectal Cancer
Second line
KRAS wild-type
216
sozkhhhbxv(jwvpllffpw) = akdcudfigq oupuimounn (bxqmrtpwcl )
Negative
25 Jun 2014
sozkhhhbxv(jwvpllffpw) = fuzsxmtqfn oupuimounn (bxqmrtpwcl )
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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