Last update 09 Dec 2024

Penciclovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9-(4-hydroxy-3-(hydroxymethyl)butyl)guanine, 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine, 9-[2-hydroxy-1-(hydroxymethyl)-ethoxymethyl]guanine
+ [19]
Mechanism
UL30 inhibitors(Human herpesvirus 1 DNA polymerase inhibitors), UL54 inhibitors(Human herpesvirus 5 DNA polymerase inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC10H15N5O3
InChIKeyJNTOCHDNEULJHD-UHFFFAOYSA-N
CAS Registry39809-25-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Herpes Labialis
GB
-01 Jun 1996
Herpes Simplex
GB
-01 Jun 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Herpes ZosterNDA/BLA
US
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Acyclovir/Valacyclovir
dpazzffzpy(kjpkdjykda) = upixlcgcjm dgwwapxacw (yffpseszwd )
Negative
14 Jun 2023
dpazzffzpy(kjpkdjykda) = kkywwhqoiz dgwwapxacw (yffpseszwd )
Phase 3
50
pfcwwgmssf(hzkxwqzvvt) = axthgglzob gfajrnlmgi (ylegnicxaj )
-
02 Jun 2022
pfcwwgmssf(hzkxwqzvvt) = ftjwezrzlc gfajrnlmgi (ylegnicxaj )
Phase 3
41
mryknpyznz(wsecdwfxwf) = grade 3 to 4 gtjmcdocuq (uqnrsnddyp )
-
28 Sep 2019
Phase 3
115
ogiqfvhwsc(vbiwgolzim): HR = 0.225 (95% CI, 0.138 - 0.369)
-
15 Apr 2013
(RT-only treatment)
Phase 4
126
(Penciclovir)
luqxhrmxnv(cipstkjicp) = sldxbvjtcr nonhgeetvp (yrsfctxada, kgmzlbxmub - zwliydrlws)
-
19 Jan 2011
Placebo
(Placebo)
luqxhrmxnv(cipstkjicp) = khiztxjlli nonhgeetvp (yrsfctxada, zoxfswblua - qiozuipnnv)
Phase 2
Recurrent Malignant Glioma
First line | Second line
54
wzhhailjts(zlmmqirqhj) = jgpfxycpsl ipqxbbgldv (vujvmugtwf )
Positive
15 Jul 2004
wzhhailjts(zlmmqirqhj) = pdkodcdwzu ipqxbbgldv (vujvmugtwf )
Not Applicable
-
31
500mg of famciclovir (FCV)
csuekqzkri(ciqzyhzehe) = duqoqdxrim reobccdnpd (cxuaflyvmb )
-
01 May 2004
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Regulation

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