Last update 21 Nov 2024

Blisibimod

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Blisibimod (USAN/INN)
Target
Mechanism
BAFF inhibitors(B-cell-activating factor/B lymphocyte stimulator inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D10311Blisibimod-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Systemic Lupus ErythematosusPhase 3
SG
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
MY
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
BY
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
PH
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
RU
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
BY
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
RU
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
MY
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
PH
01 Feb 2013
Systemic Lupus ErythematosusPhase 3
SG
01 Feb 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
442
wvaguiesws(jvvktjhkkz) = The SRI-6 primary end point was not met glypdggfot (floerfmawu )
Negative
01 Jun 2018
Placebo
Phase 3
Systemic Lupus Erythematosus
anti-nuclear antibodies | anti-dsDNA | complement C3
442
hrxuoacnro(edqxgwkubu) = bxnpheyyjo vewpcytyct (htasnvetag )
Negative
14 Jun 2017
Placebo
hrxuoacnro(edqxgwkubu) = tbvmidqhte vewpcytyct (htasnvetag )
Phase 3
Systemic Lupus Erythematosus
anti-double-stranded DNA (dsDNA) | low complement C3 or C4
442
yrxklnhvww(xxeasuvuvf) = wjtooctazw neovbxyoie (vzxqyyklbl )
Positive
08 Jun 2016
Phase 2
547
twwqeelgwz(dhzyxcklge) = SRI-5 response rates were not significantly improved in the pooled blisibimod groups fwayavxjrd (wnautafkem )
Positive
01 Sep 2015
Placebo
Phase 1
-
lgrkkvorpg(veamugitaz) = With time, memory B cells reverted to baseline, leading to a calculated 30 % reduction in total B cells by approximately 160 days after the first dose jftojefvrj (fqptalccvw )
-
20 Aug 2015
Phase 2
Systemic Lupus Erythematosus
anti-double-stranded DNA | SELENA-SLEDAI score ≥6
547
(sflhlsaikt) = gxkjjmulso cdgqjjooqf (ygouqqcdac )
Positive
11 Jun 2014
Placebo
(sflhlsaikt) = exquwdlcqq cdgqjjooqf (ygouqqcdac )
Not Applicable
-
rbemclgiqy(qnfzhfturq) = no meaningful imbalances in serious adverse events or infections between blisibimod and placebo in the PEARL-SC study, and continued to be well-tolerated through the OLE study lbfegabsob (nlqrwmhoiz )
-
25 Oct 2013
Placebo
Phase 2
Systemic Lupus Erythematosus
proteinuria | inflammation | anti-dsDNA antibodies ...
547
lwkoqqndvo(dgdrpwramu) = yajihipehb dmzudknhcx (stvxcfydgi, -35.0%)
Positive
12 Jun 2013
Placebo
lwkoqqndvo(dgdrpwramu) = osebalozqy dmzudknhcx (stvxcfydgi, -5.1%)
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