Last update 09 May 2025

Lactobacillus plantarum strain 299

Overview

Basic Info

Drug Type
Probiotics
Synonyms
DSM-6595
Target-
Action
modulators
Mechanism
Bacteria replacements, Microbiome modulators
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [1]
Active Indication
Acute Graft Versus Host DiseaseLeukemiaLymphoma+ [1]
Inactive Indication-
Originator Organization
National Cancer InstituteNational Cancer Institute
Active Organization
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Related

4
Clinical Trials associated with Lactobacillus plantarum strain 299
ChiCTR2300077434
/ SuspendedEarly Phase 1IIT
Intervention of Lactobacillus animalis and Lactobacillus plantarum in adjuvant treatment of recurrent respiratory tract infections in children
ChiCTR2300075360
/ SuspendedPhase 1IIT
Clinical study on the application of Lactobacillus plantarum in patients with functional constipation
NCT03057054
/ Active, not recruitingPhase 3IIT
The Effectiveness of Lactobacillus Plantarum (LBP, IND# 17339) in Preventing Acute Graft-Versus-Host Disease (GvHD) in Children Undergoing Alternative Hematopoietic Progenitor Cell Transplantation (HCT)
100 Clinical Results associated with Lactobacillus plantarum strain 299
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100 Translational Medicine associated with Lactobacillus plantarum strain 299
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100 Patents (Medical) associated with Lactobacillus plantarum strain 299
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100 Deals associated with Lactobacillus plantarum strain 299
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Graft Versus Host DiseasePhase 3
United States
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
30 Apr 2018
Acute Graft Versus Host DiseasePhase 3
Canada
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
30 Apr 2018
LeukemiaPhase 3
United States
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
30 Apr 2018
LeukemiaPhase 3
Canada
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
30 Apr 2018
LymphomaPhase 3
United States
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
30 Apr 2018
LymphomaPhase 3
Canada
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
30 Apr 2018
Graft vs Host DiseasePhase 3-
The Children's Oncology Group Foundation, Inc.The Children's Oncology Group Foundation, Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03057054 (CTgov)
Phase 3
Acute Graft Versus Host Disease | Leukemia | Lymphoma
173
Allogeneic Hematopoietic Stem Cell Transplantation+Lactobacillus plantarum strain 299v
(Arm I (Lactobacillus Plantarum, alloHCT))
mpeuatksef = jwmqxgdyhm wmdrdabnwa (htjlxvazky, omzkkjqlpu - bgteoudvrk)
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-
17 Jul 2023
Allogeneic Hematopoietic Stem Cell Transplantation
(Arm II (Placebo, alloHCT))
mpeuatksef = fytajyyigc wmdrdabnwa (htjlxvazky, dhhueliztw - dfefdkqdaf)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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