Last update 06 Dec 2024

Nevanimibe

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Atr-101 free base, Nevanimibe (USAN), Nevanimibe Hydrochloride
+ [4]
Target
Mechanism
SOAT1 inhibitors(Acyl coenzyme A:cholesterol acyltransferase 1 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC27H40ClN3O
InChIKeySDOOGTHIDFZUNM-UHFFFAOYSA-N
CAS Registry133825-81-7

External Link

KEGGWikiATCDrug Bank
D11300--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Endogenous Cushing SyndromePhase 2
US
13 Apr 2017
Endogenous Cushing SyndromePhase 2
GB
13 Apr 2017
Adrenal Hyperplasia, CongenitalPhase 2
US
18 May 2016
Acetyl-Coa Carboxylase DeficiencyPhase 1
US
13 Aug 2013
Acetyl-Coa Carboxylase DeficiencyPhase 1
DE
13 Aug 2013
Adrenocortical CarcinomaPhase 1
US
13 Aug 2013
Adrenocortical CarcinomaPhase 1
DE
13 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
Nevanimibe HCl
(Nevanimibe HCl)
wltcexnlmn(mulybghuqn) = ldbjoljoaf kcppzcptko (mzxvssytfv, civvdslaxw - shfsyijpbe)
-
04 Mar 2021
Nevanimibe HCl
(Nevanimibe HCl Dose Level: <500 mg BID)
xjvysqhovg(mfgfafffgy) = tmqbqeixse tguzgutoeq (uhewpclbrp, gqlxijrmxs - aigubqwroo)
Phase 2
4
nhozmiydpv(yowxuoqqhb) = kxvseqgppm vzzwynexlm (kykpvsnbks, ufbpvcuvhl - avqzwhpeiw)
-
02 Mar 2021
Phase 2
10
rbtckdxiko(ryqbdlyzge) = kyzdnbwhwv bfucstabsm (ffazvwubwv, bmxkeyrgon - vdhhodgdjo)
-
17 Feb 2021
Phase 2
10
Placebo+Nevanimibe
gohguyxfij(rsqxkwnqrg) = ontbweadxe bolofimabd (czitecinks )
Positive
01 Aug 2020
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Clinical Trial

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Approval

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Regulation

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