Delving into the Latest Updates on Etilefrine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Etilefrine, Etilefrine hydrochloride (JP17), 塩酸エチレフリン

+ [6]

Target

ADRA1 x β1-adrenergic receptor

Mechanism

ADRA1 agonists(Adrenergic receptor alpha-1 agonists), β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Hypotension

Inactive Indication-

Originator Organization

Sanofi

Active Organization

Sanofi KK

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (03 Dec 1960),

Hypotension

RegulationOrphan Drug (EU)

Login to view timeline

Structure

Molecular FormulaC10H16ClNO2

InChIKeyKTNROWWHOBZQGK-UHFFFAOYSA-N

CAS Registry943-17-9

View All Structures (2)

This work aimed to evaluate and compare the impact of adding hypertonic saline solution (HSS) infusion and/or etilefrine to oral diuretics therapy on clinical outcomes, renal and systemic hemodynamics, metabolic and inflammatory pathways by estimating the changes in selected biological markers in cirrhotic patients with ascites. Also, the trial aims to assess the safety and tolerability of such treatment regimens.

Start Date30 Nov 2017

Sponsor / Collaborator

Tanta University

JPRN-UMIN000016234 / RecruitingIIT

The effect of ephedrine and etilefrine on systolic pressure variation and pulse pressure variation - The effect of ephedrine and etilefrine on systolic pressure variation and pulse pressure variation

Start Date16 Jan 2015

Sponsor / Collaborator-

100 Clinical Results associated with Etilefrine Hydrochloride

Login to view more data

100 Translational Medicine associated with Etilefrine Hydrochloride

Login to view more data

100 Patents (Medical) associated with Etilefrine Hydrochloride

Login to view more data

194

Literatures (Medical) associated with Etilefrine Hydrochloride

27 Mar 2024·Journal of the American Chemical Society

Light in a Heartbeat: Bond Scission by a Single Photon above 800 nm

Article

Author: Generali, Melanie ; Štacko, Peter ; Janeková, Hana ; Meier, Debora ; Russo, Marina

Photocages enable scientists to take full control over the activity of molecules using light as a biocompatible stimulus. Their emerging applications in photoactivated therapies call for efficient uncaging in the near-infrared (NIR) window, which represents a fundamental challenge. Here, we report synthetically accessible cyanine photocages that liberate alcohol, phenol, amine, and thiol payloads upon irradiation with NIR light up to 820 nm in aqueous media. The photocages display a unique chameleon-like behavior and operate via two distinct uncaging mechanisms: photooxidation and heterolytic bond cleavage. The latter process constitutes the first example of a direct bond scission by a single photon ever observed in cyanine dyes or at wavelengths exceeding 800 nm. Modulation of the beating rates of human cardiomyocytes that we achieved by light-actuated release of adrenergic agonist etilefrine at submicromolar concentrations and low NIR light doses (∼12 J cm^-2) highlights the potential of these photocages in biology and medicine.

01 Mar 2024·Journal of Plastic, Reconstructive & Aesthetic Surgery

Flying high?—Exploring the effect of red bull on blood pressure after microsurgical breast reconstruction in a randomized controlled trial

Article

Author: Speck, Nicole E ; Ranacher, Christina ; Babst, Doris ; Farhadi, Jian ; Dreier, Kathrin ; Fluetsch, Andrin ; Lardi, Alessia M

BACKGROUNDA sufficiently high blood pressure (BP) is essential for flap perfusion after microsurgical breast reconstruction. However, postoperative hypotension is common after these procedures. Perioperative volume overload may increase flap-related complications, and postoperative vasopressor use may be limited depending on institutions. Red Bull has been shown to increase BP in several studies. We aimed to evaluate the effect of Red Bull on perfusion-related variables after microsurgical breast reconstruction.METHODSWe conducted a multicenter, prospective, randomized controlled trial. Female patients undergoing unilateral microsurgical breast reconstruction from June 2020 to October 2022 were randomly assigned to the intervention or control groups. The intervention group received 250 ml of Red Bull 2 h after surgery and twice on postoperative day (POD) 1. The control group received 250 ml still water at the respective intervals. BP was measured using a 24-hour monitoring device. Vasopressor use, fluid balance, and flap outcomes were compared.RESULTSOne hundred patients were included in the study. Both groups were comparable concerning age, body mass index, and caffeine consumption. Mean arterial and diastolic BP were significantly higher in the Red Bull group after the second drink in the morning of POD1 (p-value = 0.03 and 0.03, respectively). Vasopressor use was similar, with a tendency for less postoperative etilefrine in the Red Bull group (p-value = 0.08). No flap loss was observed.CONCLUSIONSWe observed increased mean arterial and diastolic BP in the Red Bull group after the second drink. Red Bull may be a useful adjunct after microsurgical breast reconstruction.LEVEL OF EVIDENCEI, therapeutic.

22 Aug 2023·ACS omega

Green Prospective Approach of Chromium Zinc Oxide Nanoparticles for Highly Ultrasensitive Electrochemical Detection of Anti-hypotensive Medication in Various Matrices.

Article

Author: Rashed, Noha S ; Elgazzar, Elsayed ; Fouad, Manal M ; Elsonbaty, Ahmed ; Otaif, Khadejah D ; Hosni, Noha Y Z

A highly ultrasensitive sensor that relied on Cr/ZnO-NPs was developed to detect etilefrine hydrochloride (ETF) in different matrices via a particular green voltammetric technique. The X-ray diffraction pattern showed the nanomaterials of the polycrystalline hexagonal structure. The energy-dispersive X-ray spectrum approved the presence of Cr³⁺ inside the host zinc oxide framework. The morphological and topological characteristics were visualized using transmission electron microscopy and atomic force microscopy micrographs describing the nanoparticles in spherical-like shape with large-surface area. The energy gap (E_g) was evaluated from transmittance (T %) and reflectance (R %) spectra within the visible region. The optimization study indicated that the Cr/ZnO-NP/CPE sensor has high sensitivity, thanks to the distinctive physical and chemical properties of the fabricated electrode. A new approach showed a great selectivity for determining ETF in different matrices in the presence of other interferents like levodopa. Under optimal circumstances, the square-wave voltammetry revealed a linear response to ETF from 0.01 to 10 μmol L^-1 (r = 0.9996) with quantification and detection limits of 9.11 and 2.97 nmol L^-1, respectively. Finally, the proposed approach was effectively applied to estimate ETF in pharmaceutical dosage forms and biological fluids using simple, accurate, and selective electrochemical electrode. The greenness profile assessment of the developed method was performed using the Eco-Scale and green analytical procedure index. These tools indicated that the proposed method is an eco-friendly technique for the determination of ETF in different matrices.

100 Deals associated with Etilefrine Hydrochloride

Login to view more data