Delving into the Latest Updates on Flavin Adenine Dinucleotide Sodium/Chondroitin Sulfate Sodium with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Flavin Adenine Dinucleotide Sodium/Sodium Chondroitin Sulfate, MUCOFADIN OPHTHALMIC SOLUTION, ムコファジン点眼液

+ [4]

Target-

Mechanism-

Therapeutic Areas

Eye Diseases

Active Indication

Corneal Diseases

Inactive Indication-

Originator Organization

Wakamoto Pharmaceutical Co., Ltd.

Active Organization

Wakamoto Pharmaceutical Co., Ltd.

ROHTO NITTEN Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (12 Dec 1966),

Corneal Diseases

Regulation-

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Structure

Molecular FormulaC27H33N9NaO15P2

InChIKeyNQOZVHXDRLWYCQ-WQLILBPHSA-N

CAS Registry84366-81-4

The effects of HCSG injections on SF lubricant properties and joint health, immediately after injury and 2 weeks later, were analyzed by use an equine osteochondral fracture model of post-traumatic osteoarthritis (OA). Middle carpal joints of adult horses were randomly assigned to 1 of 4 surgical treatment groups as follows: normal nonsurgical group (n = 8), normal sham-surgical group (8), OA-induced surgical group with HCSG injection (8), or OA-induced surgical group with saline (0.9% NaCl) solution injection (8). Synovial fluid was aspirated periodically and analyzed for boundary lubrication function and lubricant molecules. At 17 days, joints were screened for gross pathological changes.

RESULTS:

Induction of OA led to an impairment of SF lubrication function and diminished hyaluronan concentration in a time-dependent manner following surgery, with HCSG injection lessening these effects. Certain friction coefficients approached those of unaffected normal equine SF. Induction of OA also caused synovial hemorrhage at 17 days, which was lower in joints treated with HCSG.

CONCLUSIONS AND CLINICAL RELEVANCE:

After induction of OA, equine SF lubricant function was impaired. Hyaluronan-sodium chondroitin sulfate–N-acetyl-d-glucosamine injection restored lubricant properties at certain time points and reduced pathological joint changes.

01 Jul 2017·Acta orthopaedica et traumatologica turcicaQ4 · MEDICINE

The comparison of the effects of a novel hydrogel compound and traditional hyaluronate following micro-fracture procedure in a rat full-thickness chondral defect model

Q4 · MEDICINE

ArticleOA

Author: Oztas Sukur, Nur Ece ; Senel, Ahmet ; Ozturkmen, Yusuf ; Akman, Yunus Emre ; Sukur, Erhan ; Talu, Canan Kelten

PURPOSE:

The aim of this experimental study was to investigate the impact of HA-CS-NAG compound (hyaluronate, sodium chondroitin sulfate, N-acetyl-d-glucosamine) on the quality of repair tissue after micro-fracture and to compare it with HA (hyaluronat), in a rat full-thickness chondral defect model.

METHODS:

Full-thickness chondral defects were created in a non-weight bearing area by using a handle 2.7-mm drill bit, in the right knees of 33 Sprague-Dawley rats. Each specimen then underwent micro-fracture using a needle. Two weeks after surgery, 3 groups were randomly formed among the rats (n = 33). In Group 1, 0.2 mL of sterile saline solution (0.9%) was injected. In Group 2, 0.2 mL HA with a mean molecular weight of 1.2 Mda was injected. In Group 3, 0.2 mL of HA-CS-NAG compound (hyaluronate, sodium chondroitin sulfate, N-acetyl-d-glucosamine) was injected. The injections were applied on the 14th, the 21st and the 28th postoperative days. All rats were sacrificed on the 42nd postoperative day. Histological analysis of the repair tissue was performed for each specimen by two blinded observers using Wakitani scoring system.

RESULTS:

There was significantly improved repair tissue in both Group 3 and Group 2 when compared with Group 1. Group 3 showed statistically significant improvement in terms of 'cell morphology' and 'integration of donor with host' when compared to Group 2 (p < 0.001).

CONCLUSION:

Intra-articular injection of HA-CS-NAG compound after micro-fracture results in significantly improved repair tissue in rats' chondral defects when compared to HA regarding the donor integration and cell morphology.

01 Jan 2017·Vestnik oftalmologii

Effectiveness of epithelialization therapy after surgical treatment of pterygiu

Article

Author: Trishkin, K S ; Petraevskiy, A V ; Gndoyan, I A

AIM:

to compare the effectiveness, safety and tolerability of different keratoprotectors in patients after surgical treatment of pterygium.

MATERIAL AND METHODS:

A total of 60 patients (73 eyes) with pterygium were operated on using classic McReynolds technique. Depending on the keratoprotector used postoperatively (Korneregel, Balarpan, or Stillavit), the patients were divided into three groups of 20 persons. In each group, the clinical picture during the postoperative period was evaluated at days 1, 3, and 7.

RESULTS:

As to the subjective symptoms relief and stimulation of epithelization, Stillavit capability was comparable to that of Korneregel, but Stillavit was free of the common side effect of Korneregel - blurred vision after instillation. Epithelialization rate under Stillavit therapy was higher than that under Balarpan.

CONCLUSION:

Stillavit can be recommended as the drug of choice for patients after surgical treatment of pterygium. Components of the preparation (0.16% sodium hyaluronate, 0.05% sodium chondroitin sulfate, and 1% dexapanthenolum) act on each of the links in the pathogenesis of recurrent pterygium - slow epithelialization of the cornea, associated inflammation and formation of dry areas of the cornea.

100 Deals associated with Flavin Adenine Dinucleotide Sodium/Chondroitin Sulfate Sodium

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