Delving into the Latest Updates on Wakamoto Pharmaceutical Co., Ltd. with Synapse

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Eye Diseases

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Immune System Diseases

Small molecule drug

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Disease Domain	Count

Immune System Diseases	4
Nervous System Diseases	3
Endocrinology and Metabolic Disease	3
Infectious Diseases	3
Neoplasms	2
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	8
Probiotics	2

Top 5 Target	Count

GR(Glucocorticoid receptor)	2
ADRA1 x mAChRs	1
β-adrenoceptors(Beta adrenergic receptors)	1
COX(Cyclooxygenases)	1
50S subunit(50S ribosomal subunit)	1

Introduction: Heat shock protein (Hsp) 90 is one of the most abundant proteins in unstressed cells and regulates stability and functional maintenance of client proteins. In ocular tissue, Hsp90 is widely expressed in the cornea and retina and has multiple roles in these tissues. The expression of HSPs was induced in the retinas of glaucomatous patients and laser-induced glaucoma in monkey while their mechanisms remain to be elucidated. For this reason, we tried to elucidate the role of Hsp90 in intraocular pressure (IOP) regulation in rabbits. Methods: IOP was measured by a pneumatonometer before and after intracameral injection of Hsp90 inhibitors. The aqueous flow rate was measured by fluorophotometry. Trans-epithelial electrical resistance was measured in primary human trabecular meshwork cells. Results: 17-AAG, a specific Hsp90 inhibitor, significantly lowered IOP at concentrations of more than 30 μ<sc>m</sc> in normotensive rabbits. Other Hsp90 inhibitors also significantly lowered IOP in normotensive rabbits at a dose of 100 μ<sc>m</sc>. No reduction of aqueous humor production was observed by injection of 17-AAG in rabbits. Topical administration of pilocarpine tended to attenuate the IOP-lowering effects induced by the Hsp90 inhibitor. No reduction of trans-epithelial electrical resistance was observed by inhibition of Hsp90 in culture cells. Conclusions: These results indicated that intraocular Hsp90 regulates IOP, and the inhibition of Hsp90 by Hsp90 inhibitor decreases IOP without affecting aqueous humor production in rabbits. Further research in elucidating the mechanism of Hsp90 inhibitors will result in a better understanding of the role of Hsp90 in the regulation of IOP.

01 Jan 2023·Journal of Pharmacological Sciences

Effect of triamcinolone acetonide on retinal inflammation and angiogenesis induced by pericyte depletion in mouse

Article

Author: Naito, Akira ; Suzuki, Ayako ; Otsuka, Tomohiro ; Arakawa, Reijiro ; Takahashi, Yuji ; Uemura, Akiyoshi ; Okabe, Takeshi ; Masuda, Tomomi

Triamcinolone acetonide (TA) has been shown to improve morphological and functional outcome in diabetic macular edema (DME) patients. However, the functional mechanism of TA has not been elucidated yet. In this study we investigated the detailed functional mechanism of TA using culture cells and retinopathy mouse models in which retinal inflammation and abnormal angiogenesis were induced by pericyte depletion. TA significantly prevented retinal hemorrhage, edema and partially improved abnormal angiogenesis. TA decreased retinal vascular endothelial growth factor (VEGF) concentration, presumably by preventing recruitment of macrophages into retina and TA also inhibited expression of inflammatory cytokines in retina. TA inhibited proliferation/migration of vascular endothelial cells and vessel sprouting. No direct inhibition of VEGF receptor 2 (VEGFR2) autophosphorylation was observed by TA. These results suggested that TA improved inflammatory retinal events which were induced in pericyte-deleted mice by mainly decreasing macrophage-derived VEGF and expression of inflammatory cytokines followed by attenuation of vascular permeability and proliferation/migration of endothelial cells. Furthermore, in these processes, translocation of glucocorticoid receptor (GR) was partially involved.

01 Jan 2023·BPB Reports

Intake of Lactobacillus Pentosus TJ515 Prevents the Formation of Retinal Edema in Retinal Vein Occlusion Model Mice

Author: Kuriyama, Aika ; Shimazawa, Masamitsu ; Hidaka, Yae ; Hara, Hideaki ; Nishinaka, Anri ; Nakaya, Seigo ; Takahashi, Kei ; Kubota, Takeshi ; Nakamura, Shinsuke

100 Deals associated with Wakamoto Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with Wakamoto Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

10

6

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Antibiotics-Resistant Lactic Acid Bacteriae(Wakamoto Pharmaceutical)	Dysbacteriosis More	Approved
Acitazanolast Hydrate	Seasonal allergic conjunctivitis More	Approved
Flavin Adenine Dinucleotide Sodium/Chondroitin Sulfate Sodium	Corneal Diseases More	Approved
Timolol Maleate ( β-adrenoceptors )	Cataract More	Approved
Triamcinolone Acetonide ( GR )	Diabetic macular oedema More	Approved