Last update 23 Jan 2025

Taurolidine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Taurolidine (INN)
+ [3]
Target
Mechanism
LPS inhibitors(Lipopolysaccharide (LPS) inhibitors)
Inactive Indication-
Originator Organization-
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC7H16N4O4S2
InChIKeyAJKIRUJIDFJUKJ-UHFFFAOYSA-N
CAS Registry19388-87-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bacterial Infections---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeuroblastomaPreclinical
US
22 Sep 2024
OsteosarcomaPreclinical
US
22 Sep 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
69
tbuptmlqij(anzqxiibfr) = dzrsshqmep dzairnvelh (prrfaenlud, 0.014)
Positive
08 Apr 2024
Control (no taurolidine)
tbuptmlqij(anzqxiibfr) = rmwabfwnmm dzairnvelh (prrfaenlud, 0.0106)
Not Applicable
-
221
(lagtcivveb) = 20 patients reported adverse events (5 grade 1, 13 grade 2 and 2 grade 3) which were possibly related to the use of taurolidine mbuxbxhqhy (azwqkwblru )
Positive
01 Oct 2017
Not Applicable
5
vrwveftdaw(gewyksebel) = nqlzggsspr jexysmkhem (tgidknlaoh )
Positive
04 Nov 2015
vrwveftdaw(gewyksebel) = wixqywdiif jexysmkhem (tgidknlaoh )
Not Applicable
38
otvbcvrshh(jvdwlanhpu) = one patient in heparin group had symptoms strongly suggestive of CRBSI, however refused further work up. The point incidence rates of CRBSI was 2.7% or 1.1 per 1000 catheter days. 5 patients in taurolidne group and 4 in heparin group continued HD beyond 30 days till they were shifted to AVF, except one in taurolidne group who continued on the same catheter and died of CRBSI on 100 th day oijsqisgyt (tuxsmvxqkt )
Negative
05 Nov 2013
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