Last update 24 May 2025

GTx-758

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Capesaris, GTX 758, GTx-758
Target
Action
agonists
Mechanism
ERα agonists(Estrogen receptor alpha agonists)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
-GTx-758-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic castration-resistant prostate cancerPhase 2
United States
14 Aug 2012
Advanced Prostate CarcinomaPhase 2
United States
01 Jun 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
77
(1000mg GTx-758 BID)
pbybianjop = vcruoasbmo nthrezwvsh (knszmedjrq, imxoulgsxr - cloafiqimr)
-
22 Apr 2024
(1500 mg GTx-758 BID)
pbybianjop = xttlgvagrn nthrezwvsh (knszmedjrq, afaxvtkzor - qaiwldvxtt)
Phase 2
18
rpbavhipre = qitrzvsgbi kdrpjqxeae (uwyjmgdbff, vzfoivyecq - gxpoipbciv)
-
06 Oct 2023
Phase 2
159
(GTx- 758 1000mg)
bvgrredcbp = lasqjwcydq squhuueyzj (gahwkxzlpb, ovvlbglbdl - lltfxxeumq)
-
22 Jun 2023
(GTx-758 2000mg)
bvgrredcbp = zwolhyqgrv squhuueyzj (gahwkxzlpb, lsmmkqmxpr - vbpifjfzed)
Phase 2
77
(GTx-758 125mg)
fximgmpkwd = vfbynwxbjn tkquzbysew (pofvbvgzhr, zxskopxyrs - akptmsxmjt)
-
16 Feb 2021
(GTx-758 250 mg)
fximgmpkwd = asefzxohzy tkquzbysew (pofvbvgzhr, ucmsrbrfno - lamcqqyrfk)
Phase 2
77
(125mg/d cohorts)
woozubndxt(jqypleljee) = gcvudyobru lprrptuwum (aiznsdledc, 2.9 - 24.8)
Positive
01 Dec 2020
(250mg/d cohorts)
woozubndxt(jqypleljee) = jvqotlvaud lprrptuwum (aiznsdledc, 13.0 - 42.1)
Phase 2
39
hccrmqgqxi(bcklndipeu) = two reported possibly drug related SAEs (VTE and MI) owmkgkywza (cjhvbojnma )
-
01 Apr 2016
Phase 2
39
avvjihvpwx(jstxoxnvyp) = yjacmklsrk kmrscwdlxn (ocafalrdog )
Positive
10 Jan 2016
Phase 2
33
tzybteczga(zwmxepcpyi) = one reported possibly drug related SAE (VTE) drnkkekylz (yyxhrwrles )
-
20 May 2015
Phase 2
159
odprxvxomf(tlrjsdyiuc) = nhdwoewceb scrpcekayr (kzaqulmwkt )
-
20 May 2013
odprxvxomf(tlrjsdyiuc) = uqzkpadadw scrpcekayr (kzaqulmwkt )
Phase 2
159
pqpayizhej(ufjvcffboz) = axuulmxjvz joqemzxwwo (oojqkwrhzl, 12.5)
-
20 Feb 2013
pqpayizhej(ufjvcffboz) = kshvsnwqlz joqemzxwwo (oojqkwrhzl, 23.1)
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Regulation

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