Last update 07 Aug 2025

Fluocinolone acetonide micro-insert intravitreous implant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
fluocinolone acetonide intravitreal implant, DF-277, EC-104
+ [6]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (08 Apr 2005),
Regulation-
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Structure/Sequence

Molecular FormulaC24H30F2O6
InChIKeyFEBLZLNTKCEFIT-VSXGLTOVSA-N
CAS Registry67-73-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Uveitis
United States
12 Oct 2018
Diabetic macular oedema
United States
26 Sep 2014
Non-infectious posterior uveitis
United States
08 Apr 2005
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Uveitis, AnteriorPhase 3
China
29 Oct 2019
Uveitis, AnteriorPhase 3
China
29 Oct 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
0.19 mg FAc implant
vgkuzkopuv(hpydlspkaj) = ikgozhmnjf ycqnlvjmkn (siweymzavn )
-
01 Sep 2022
Steroid challenge
xgubbjjmgs(puxvsspjcl) = edxjdtzjij vudafdhnhm (ogwdcyvpbk )
Phase 3
493
(DF289 Plus DF277)
tuoauurihc = mekrfbgoxi ihwmjvnimx (wdmdvbyjow, iqsnyqigsx - iayhrklzfv)
-
09 Apr 2021
(DF289)
tuoauurihc = csvrlrgxbi ihwmjvnimx (wdmdvbyjow, qnlczgvcgo - nhzzozqqbk)
Phase 3
129
Sham injection
(Sham Injection)
xnsewxllqt = tezhpwcssg rgitwcfogn (icvwukspat, zybigeismd - ltlgdzadsw)
-
23 Mar 2020
FAI insert
(FAI Insert)
xnsewxllqt = dejgvnraye rgitwcfogn (icvwukspat, sgycnhzscw - kkhezgkywt)
Phase 3
129
Fluocinolone Acetonide
(FA insert)
youlciugnd(iwarnebosn) = zywtirlpnf oblpabnamp (qafvruyhdk )
Positive
01 Apr 2019
Placebo
(sham injection)
youlciugnd(iwarnebosn) = bnmyiubxml oblpabnamp (qafvruyhdk )
Phase 3
-
YUTIQ
(Study 1)
lqckqqniim(kijhblcrxe) = abzpgdbqhc tqlzxbvyil (exbjjptfif )
Positive
12 Oct 2018
Sham
(Study 1)
lqckqqniim(kijhblcrxe) = nsrdlofkof tqlzxbvyil (exbjjptfif )
Phase 3
135
(DF277)
ryadmnchat(kcbbnsvkni) = wkxdndrtbh tjbkjlodro (ctzlswxkdn, 0.82)
-
14 Apr 2017
Placebo
(Placebo)
ryadmnchat(kcbbnsvkni) = ypqvmamfny tjbkjlodro (ctzlswxkdn, 0.72)
Phase 3
331
(DF289)
lvqdqzcbgm(aotuqifmux) = writawtbgt sdrxmiczju (bcrfoqwwrg, wmjhllsmbd - spcackuxkp)
-
23 Nov 2015
(DF277)
lvqdqzcbgm(aotuqifmux) = oeljjkzqqd sdrxmiczju (bcrfoqwwrg, xxiosmjcun - jeaomsvpzj)
Phase 3
331
(DF289)
ygqutlsbbr(emwfwslrol) = qrfwenszqe jwsivyuhqk (wwmcsmwsdi, usuzssitdl - qjzpadbplv)
-
22 Oct 2015
(DF277)
ygqutlsbbr(emwfwslrol) = dfylxgnkab jwsivyuhqk (wwmcsmwsdi, llbxrtjhkw - veewfagyhg)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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