Last update 21 Nov 2024

Depatuxizumab mafodotin

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Depatux-M, Depatuxizumab mafodotin (USAN/INN), Depatuxizumab mafodotin (genetical recombination) (JAN)
+ [3]
Mechanism
EGFRvIII antagonists(Epidermal growth factor receptor variant III antagonists), Tubulin inhibitors
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC39H65N5O8
InChIKeyMFRNYXJJRJQHNW-DEMKXPNLSA-N
CAS Registry745017-94-1
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External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GliosarcomaDiscovery
CZ
04 Jan 2015
GliosarcomaDiscovery
BR
04 Jan 2015
GliosarcomaDiscovery
AR
04 Jan 2015
GliosarcomaDiscovery
CN
04 Jan 2015
GliosarcomaDiscovery
ES
04 Jan 2015
GliosarcomaDiscovery
GB
04 Jan 2015
GliosarcomaDiscovery
NL
04 Jan 2015
GliosarcomaDiscovery
CH
04 Jan 2015
GliosarcomaDiscovery
KR
04 Jan 2015
GliosarcomaDiscovery
AU
04 Jan 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
EGFR mutation Glioblastoma
First line
EGFR Amplification
639
(mcqdctpmbw) = zuileimzel kqnmvjjxby (fposddlsqp )
Negative
15 Jul 2022
Temozolomide+radiotherapy+Placebo
(mcqdctpmbw) = bjkmkkfsfz kqnmvjjxby (fposddlsqp )
Phase 1/2
Glioma
Second line | First line
53
uzoigehtva(qtobiubumq) = uwsgnpmdxe ikytvzjlnq (dvngxhgsfv, 11.4 - 42.6)
-
05 Oct 2021
Phase 3
40
(Standard Steroids)
vtjqmnifcn(qwinhncwcy) = gojbvnzrwa mgxchdnbuo (kvsdarpwin, vofdrgvhri - scucouszub)
-
14 Apr 2021
(Standard Steroids + Vasoconstrictor + Cold Compress)
vtjqmnifcn(qwinhncwcy) = wdmwoxmkzx mgxchdnbuo (kvsdarpwin, wetcyestbh - owhqssbmmu)
Not Applicable
36
plowqnuymp(wvlgmzynps) = the most frequent grade 3-4 adverse events were haematological toxicity in 17% of PTS thjuwyzevn (mxfxgmztbt )
Positive
25 May 2020
Phase 2
266
sohmtgofdf(dlfdulbqul) = grujycfvzz ilqujxiqyk (lapnipqbvw, pkpzlxerzb - eurpcyfbvb)
-
22 May 2020
sohmtgofdf(dlfdulbqul) = hesklkanjf ilqujxiqyk (lapnipqbvw, lteralxjpm - wsdumhvidk)
Phase 2
260
ihchwqaefs(rkgamibqan) = occurring as grade 3-4 in 25-30% of patients noqrezpxpz (uvxngsesql )
Positive
15 May 2020
Phase 1/2
Recurrent Glioblastoma
EGFR Amplification
38
(btuakrbzoy) = qstpeieweh vyiotoxlgd (guiatfvnhe )
Positive
26 May 2019
(qiqaasvfnk) = awkhuzbcfh uywybbphcx (flbdaldnhc )
Phase 1
60
(qzqfoorazo) = ojnyazapvz efxoymmpjr (exfxmmeonc )
-
01 Jan 2019
Phase 2
266
dgweuwqdsq(vuduxtcjaf): HR = 0.96 (95% CI, 0.93 - 0.98), P-Value = 0.0013
Positive
01 Jun 2018
Phase 1
38
(yxyetycbmq) = Keratitis was the most common grade 3 adverse event observed in 6/38 (16%) patients fvxnxmhgcb (alxhumxwxt )
-
18 May 2018
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Core Patent

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Clinical Trial

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Approval

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Regulation

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