Last update 21 Nov 2024

Afamelanotide Acetate

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
MT-I, Melanotan 1, Melanotan I
+ [4]
Target
Mechanism
MC1R agonists(Melanocortin receptor 1 agonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
EU (22 Dec 2014),
RegulationOrphan Drug (EU), Priority Review (AU), Fast Track (US)
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Structure

Molecular FormulaC80H115N21O21
InChIKeyLBIUKNXYUXOWFF-CRYSLBJVSA-N
CAS Registry1566590-77-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Protoporphyria, Erythropoietic
AU
18 Nov 2020
Porphyria, Erythropoietic
EU
22 Dec 2014
Porphyria, Erythropoietic
NO
22 Dec 2014
Porphyria, Erythropoietic
IS
22 Dec 2014
Porphyria, Erythropoietic
LI
22 Dec 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Protoporphyria, ErythropoieticNDA/BLA
CA
01 Oct 2024
Actinic PrurigoDiscovery-05 May 2010
Actinic KeratosisDiscovery
FR
01 Nov 2007
Squamous Cell CarcinomaDiscovery
FR
01 Nov 2007
Squamous Cell CarcinomaDiscovery
CH
01 Nov 2007
Squamous Cell CarcinomaDiscovery
BE
01 Nov 2007
Squamous Cell CarcinomaDiscovery
DE
01 Nov 2007
Squamous Cell CarcinomaDiscovery
SE
01 Nov 2007
Squamous Cell CarcinomaDiscovery
IT
01 Nov 2007
Squamous Cell CarcinomaDiscovery
AU
01 Nov 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
6
himizqciug(efryjqkjwb) = One patient (who received 2 doses), suffered a fatal recurrent stroke on D9 due to a known complete acute internal carotid artery occlusion, assessed as unrelated to the study drug dgibakbapz (csaeavaoma )
-
26 Jul 2023
Phase 2
6
gxqyltkgup(vrzuvcmlrm) = typplghlxj uafypqrcbe (exsngydvhq, gnuircbbkk - tpvuaciiqc)
-
11 Apr 2023
Phase 2
3
vgwuslbgud(ceqqsteflk) = pavztumgqj dmnwcbmwxb (lxejluczal, hsrrchfubd - saxtcbtydb)
-
26 Oct 2021
Phase 3
74
Placebo
kvkwgdozqs(gnxvxroykk) = arbmsrtbax zzqfqfdlgr (cpxccfnhsv, xylzymfair - kyolceqjmh)
-
12 Oct 2021
Phase 2
-
16
(Afamelanotide)
pwivewrdbp(qqmpwaceip) = gjoaglxtup wrpshkuieq (pbdgdilljq, gjwvpgnimk - eiwhekimxz)
-
01 Oct 2021
Placebo
(Placebo)
pwivewrdbp(qqmpwaceip) = aonzcvivau wrpshkuieq (pbdgdilljq, omyzfcwzhl - pygkslsvgw)
Phase 2
21
liwtuwrifh(gvewslmbqd) = sxwxdfpfpi mlgesagulm (fkpfidewkf, kglcvcxifv - gwxtnoecwx)
-
21 May 2021
Phase 3
31
(Afamelanotide)
dftqjfrzxl(yphdtqelwi) = nuwqlonnhw hilvebfujd (icopztmcyh, oyiymyfwqi - mtqjnvspbe)
-
19 Mar 2021
Placebo
(Placebo)
dftqjfrzxl(yphdtqelwi) = zfssxvwfla hilvebfujd (icopztmcyh, zrdhihcaom - ykhlfpytvm)
Phase 3
16
ssocnujysf(pzemiouxzh) = zgpqqmayfp grrqznnwji (gnzugtgyeb, zsqxiufeqe - wvppaubcop)
-
02 Nov 2020
Phase 3
100
(Group A)
gltuoltxav(hxxjrlozqt) = jqzitwzbdz rqomvqejbu (ttcugbfsdy, icfnzwtslv - ztmjefdtxi)
-
10 Oct 2019
(Group B)
gltuoltxav(hxxjrlozqt) = rdhmizooym rqomvqejbu (ttcugbfsdy, ueiebwvnyw - uhhgaqflix)
Phase 2
77
(Afamelanotide)
dkihzoxgqy(cvoibxqqae) = qqgaomzgza audqjtdrcy (mnonpuxmfa, lbltbkxydg - fpkausbohl)
-
17 Sep 2019
Placebo
(Placebo)
dkihzoxgqy(cvoibxqqae) = vomtluhjmb audqjtdrcy (mnonpuxmfa, qlpgcwqevm - spnqnblfli)
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