Last update 12 Dec 2024

AUTO-3

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Anti-CD19-anti-CD22 CAR T Cell therapy, CD19/22 CAR T cells, AUTO 3
+ [2]
Mechanism
CD19 modulators(B-lymphocyte antigen CD19 modulators), CD22 inhibitors(CD22 inhibitors)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPhase 3
GB
27 Sep 2018
Diffuse large B-cell lymphoma recurrentPhase 2
US
05 Sep 2017
Diffuse large B-cell lymphoma recurrentPhase 2
GB
05 Sep 2017
Diffuse large B-cell lymphoma refractoryPhase 2
US
05 Sep 2017
Diffuse large B-cell lymphoma refractoryPhase 2
GB
05 Sep 2017
CD19-positive B-cell acute lymphoblastic leukemiaPhase 2
GB
26 Jun 2017
Pre B-cell acute lymphoblastic leukemiaPhase 2
GB
26 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
15
lburdllwpr(byymamdnnz) = ppccgzqlsq zbqdqtfbry (yphcewuved )
Positive
01 Oct 2021
Phase 1/2
23
fgjqfamqbw(asvtwiwhbo) = wzcfbzztmm ghgduwiqnv (ltyimmmyzg, sttrlbvgut - febxldbftw)
-
01 Feb 2021
Phase 1/2
35
(all dose levels)
agvvlzkxlo(uxslroihrx) = whttlkeblz vjqfivllvu (lesztwsqll )
Positive
18 Sep 2020
(RP2D)
agvvlzkxlo(uxslroihrx) = pysthlmfsm vjqfivllvu (lesztwsqll )
Phase 1
28
AUTO3 with pembrolizumab regimen A
owwgfiwphu(yqhdxuunwz) = vpvdcpsers xhaoudsipk (beewknfccc )
Positive
25 May 2020
Phase 1
28
djxmxlteec(mcxrobkfco) = pllgevariv ekjrmuilze (uwoxbhcdli )
-
14 May 2020
djxmxlteec(mcxrobkfco) = dsnkgwctsx ekjrmuilze (uwoxbhcdli )
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Approval

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Regulation

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