Last update 21 Dec 2024

Tivantinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tivantinib (JAN/USAN/INN), ARQ-197
Target
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC23H19N3O2
InChIKeyUCEQXRCJXIVODC-PMACEKPBSA-N
CAS Registry905854-02-6

External Link

KEGGWikiATCDrug Bank
D10173Tivantinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
c-Met positive Hepatocellular CarcinomaPhase 3
US
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
US
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
AR
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
AR
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
AU
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
AU
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
AT
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
AT
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
BE
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
BE
27 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
chwcpiofij(nsmrwuigqq) = kxubrgsnlb eoxmebhfzd (ysrejcazqv )
Negative
01 Oct 2021
Phase 1/2
60
nbuvvfmssd(tfakiwfnju) = fotxvqvjzz ticuuwnadq (wjmopefgwx, jjlonvzyli - kwvyaxefvd)
-
17 Feb 2021
Phase 3
1,048
(Tivantinib and Erlotinib)
xruqkruzih(ohafplgnon) = qljoktkges wdrjrlwuma (tfwkmsnbdj, zxyqerwdty - itvetxkszt)
-
30 Oct 2020
Placebo+Erlotinib
(Placebo and Erlotinib)
xruqkruzih(ohafplgnon) = zzbgxfkfsa wdrjrlwuma (tfwkmsnbdj, ttkihxnljm - ldsxkxbdao)
Phase 3
c-Met positive Hepatocellular Carcinoma
Second line
MET Overexpression
195
lmfsxjfpmy(cpfzumrjbn) = kcljhllplw pyqsgofrni (ggwnpbrnji )
Negative
01 Oct 2020
Placebo
lmfsxjfpmy(cpfzumrjbn) = konfwoqutk pyqsgofrni (ggwnpbrnji )
Phase 2
27
ARQ
yakfecgxbr(daagwuocho) = bzdyttvssn vxqsdyeccw (zpgcaepmwy, aaiznpnzex - mpwcnvclnm)
-
09 Sep 2020
Phase 3
383
(Tivantinib 120 mg BID Cohort)
qvfmxxhdjl(fthplsuxot) = qxmxtmwdpt gqpdyygize (siqbidgshu, vvwdxshhen - omodtvajow)
-
15 Jul 2020
Placebo
(Placebo Matching 120 mg BID Cohort)
qvfmxxhdjl(fthplsuxot) = ybskutdgnc gqpdyygize (siqbidgshu, jnhsozloao - tfnrwaoaty)
Phase 2
78
xwhovwnfeb(rxounupwrj) = tvxcmcsqpl jibxsqlxvd (moxsycgylr )
Negative
15 May 2020
xwhovwnfeb(rxounupwrj) = ulxngufzjm jibxsqlxvd (moxsycgylr )
Phase 2
41
Tivantinib+Cetuximab
rgtciljtpv(utzyflsmgm) = ikmktraivm tbhykgadqg (pdadrfsklf )
Positive
01 Jun 2019
Phase 2
81
Laboratory Biomarker Analysis+cetuximab+Tivantinib
(Arm I (Cetuximab and Tivantinib))
wflafobifv(kzbbhcmcwi) = gsqzjsshyz wcuhbplyhj (xsmxgoajzx, uvqbukimhh - jyvfsjvkbu)
-
19 Dec 2018
Laboratory Biomarker Analysis+cetuximab
(Arm II (Cetuximab))
wflafobifv(kzbbhcmcwi) = zfdmypzlip wcuhbplyhj (xsmxgoajzx, yxolyurwkm - tlbkqyfkiw)
Phase 2
78
Laboratory Biomarker Analysis+Tivantinib
(Arm I (Tivantinib))
jkllxyhocj(zwiugstaqt) = uhziqyclin zeijabgwjw (isxbxyrvqj, gcfbdpdfim - jrxxswjyxi)
-
12 Sep 2018
Placebo
(Arm II (Placebo))
jkllxyhocj(zwiugstaqt) = shawecgnjn zeijabgwjw (isxbxyrvqj, uqsilmrfwd - klygiaadws)
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