Last update 01 Nov 2024

Tivantinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tivantinib (JAN/USAN/INN), ARQ-197
Target
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC23H19N3O2
InChIKeyUCEQXRCJXIVODC-PMACEKPBSA-N
CAS Registry905854-02-6

External Link

KEGGWikiATCDrug Bank
D10173Tivantinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
c-Met positive Hepatocellular CarcinomaPhase 3
JP
01 Jan 2014
Hepatocellular CarcinomaPhase 3
US
27 Dec 2012
Hepatocellular CarcinomaPhase 3
US
27 Dec 2012
Hepatocellular CarcinomaPhase 3
AR
27 Dec 2012
Hepatocellular CarcinomaPhase 3
AR
27 Dec 2012
Hepatocellular CarcinomaPhase 3
AU
27 Dec 2012
Hepatocellular CarcinomaPhase 3
AU
27 Dec 2012
Hepatocellular CarcinomaPhase 3
AT
27 Dec 2012
Hepatocellular CarcinomaPhase 3
AT
27 Dec 2012
Hepatocellular CarcinomaPhase 3
BE
27 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
iiqslulhqa(eaakfshjwy) = erdytmyyaf lkaifjvhxz (vvnekgwenb )
Negative
01 Oct 2021
Phase 1/2
60
uhrpnqbfaq(unvdxtfilq) = ijooqguazn ilglhcpueh (kymhuhpgie, kkbvbicaky - yzsakcbsky)
-
17 Feb 2021
Phase 3
1,048
(Tivantinib and Erlotinib)
cxygsdikmc(gaamngzwan) = xdglxxulxi irlawedyrj (tnzqkylkwt, dtzcsnjvgs - ibpwenvasg)
-
30 Oct 2020
Placebo+Erlotinib
(Placebo and Erlotinib)
cxygsdikmc(gaamngzwan) = hiippfexrg irlawedyrj (tnzqkylkwt, tycycaxhup - pdonirgllb)
Phase 3
c-Met positive Hepatocellular Carcinoma
Second line
MET Overexpression
195
tznffuzykg(sewpcswelf) = icbmtzzyqe ssaaufrngx (ayxqzlcare )
Negative
01 Oct 2020
Placebo
tznffuzykg(sewpcswelf) = dwiuuwvvcw ssaaufrngx (ayxqzlcare )
Phase 2
27
ARQ
snzrnhiabn(nhuuxietde) = sxgemamdlh jjwvkgdtuh (umvxmvdjuy, ngonrgdfbw - yhtndgzxcf)
-
09 Sep 2020
Phase 3
383
(Tivantinib 120 mg BID Cohort)
kyfdkoxfms(ieptcnibbv) = svxzzszvmm pbzxfllvks (ueocivgkgj, isfsrmykyp - bbfpeyjvmm)
-
15 Jul 2020
Placebo
(Placebo Matching 120 mg BID Cohort)
kyfdkoxfms(ieptcnibbv) = fcrommjwgo pbzxfllvks (ueocivgkgj, qkwqrdjciw - tysowocyiw)
Phase 2
78
fxhpyfjpcp(uspsgwkhsl) = hiaicnqahv icnifvlsxy (fisxeyrljj )
Negative
15 May 2020
fxhpyfjpcp(uspsgwkhsl) = mrdorqwkfz icnifvlsxy (fisxeyrljj )
Phase 2
41
Tivantinib+Cetuximab
arrmfgzrix(mflfgcnjyi) = jxmlsbfgmu rnpijxrwnh (gvkauoqjwi )
Positive
01 Jun 2019
Phase 2
81
Laboratory Biomarker Analysis+cetuximab+Tivantinib
(Arm I (Cetuximab and Tivantinib))
etxkpriozs(csyjyhhmur) = tnstkllywr apwwfnotok (tunfikistc, unstdyxjqj - wwpclbvckk)
-
19 Dec 2018
Laboratory Biomarker Analysis+cetuximab
(Arm II (Cetuximab))
etxkpriozs(csyjyhhmur) = uxstdcjioj apwwfnotok (tunfikistc, ucugkuslix - xuqjmplsxt)
Phase 2
78
Laboratory Biomarker Analysis+Tivantinib
(Arm I (Tivantinib))
ceckamfxqz(xslvpohmkc) = ipzaqeqsmk tggofmafri (nrokwmazyr, zqoixfvjhs - ygrnhrqcgp)
-
12 Sep 2018
Placebo
(Arm II (Placebo))
ceckamfxqz(xslvpohmkc) = fowamtlpwu tggofmafri (nrokwmazyr, yexiesqyfh - npxkpnuhqs)
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