HMG-CoA reductase inhibitors(HMG-CoA reductase inhibitors), NPC1L1 inhibitors(Niemann-Pick C1-like protein 1 inhibitors), Cholesterol absorption inhibitors

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Egis Gyógyszergyár Zrt.

Active Organization

Egis Gyógyszergyár Zrt.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

NL (05 Feb 2014)

Regulation-

Structure

Molecular FormulaC44H54F2N6O12S2Zn

InChIKeyKUQHZGJLQWUFPU-UHFFFAOYSA-L

CAS Registry953412-08-3

View All Structures (2)

Clinical Trials associated with Ezetimibe/Rosuvastatin Zinc

NCT06186037 / RecruitingPhase 4IIT

Clinical Comparison of Low-dose Rosuvastatin Plus Ezetimibe Combination Therapy and High-dose Rosuvastatin Monotherapy in Patients With Minimal to Intermediate Coronary Artery Disease Without Percutaneous Coronary Intervention : A Prospective, Multicenter, Randomized, Open-label Trial

[Purpose of the Clinical Study]:The purpose of this study is to conduct a clinical comparison of low-dose rosuvastatin plus ezetimibe combination therapy and high-dose rosuvastatin monotherapy in patients with minimal to intermediate coronary artery disease without percutaneous coronary intervention to confirm non-inferiority in the reduction of key cardiovascular events.
[Hypothesis]:In patients who have not undergone percutaneous coronary intervention for minimal to moderate coronary artery disease, low-dose rosuvastatin and ezetimibe combination therapy are non-inferior in terms of reducing major cardiovascular events compared to high-dose rosuvastatin monotherapy.

Start Date01 Feb 2024

Sponsor / Collaborator-

NCT04862962 / CompletedNot Applicable

Retrospective Study to Evaluate the Safety of the Fixed-dose Combination Rosuvastatin / Ezetimibe as a Treatment for Patients With Dyslipidaemia in Usual Medical Practice.

Retrospective, analytical, longitudinal, multicenter study to evaluate the safety of the fixed-dose combination of rosuvastatin / ezetimibe as treatment for patients with dyslipidemia in routine medical practice.

Start Date30 Sep 2021

Sponsor / Collaborator

Laboratorios Silanes SA de CV

NCT04669041 / CompletedPhase 3

A Randomized Double-blinded, Double Dummy, Active-controlled, Parallel Design, Phase 3 Clinical Trial to Evaluate the Efficacy and the Safety of Single Pill Combination (SPC) Ezetimibe/Rosuvastatin in Chinese Adult Patients With Primary Hypercholesterolemia, Not Adequately Controlled on Statin Therapy

Primary Objective:
To demonstrate the superiority of the single pill combination (SPC) ezetimibe 10 mg/rosuvastatin 10 mg (E10/R10) compared to rosuvastatin 10 mg (R10), in the reduction of low density lipoprotein cholesterol (LDL-C) after 8 weeks.
Secondary Objectives:
To evaluate the proportion of patients who attain their LDL-C goal.
To evaluate the effect of SPC (E10/R10) compared to rosuvastatin 10 mg (R10) in reduction of LDL-C at Week 4.
To evaluate the effect of SPC (E10/R10) compared to R10 on other lipid parameters at Week 4 and Week 8.
To evaluate the safety of SPC (E10/R10) and R10.

Start Date08 Dec 2020

Sponsor / Collaborator

Sanofi

100 Clinical Results associated with Ezetimibe/Rosuvastatin Zinc

100 Translational Medicine associated with Ezetimibe/Rosuvastatin Zinc

100 Patents (Medical) associated with Ezetimibe/Rosuvastatin Zinc

100 Deals associated with Ezetimibe/Rosuvastatin Zinc

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	C10BA	-

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