Last update 08 May 2025

USL-311

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
CXCR4
Action
antagonists
Mechanism
CXCR4 antagonists(C-X-C motif chemokine receptor 4 antagonists)
Therapeutic Areas
NeoplasmsNervous System DiseasesOther Diseases
Active Indication
Glioblastoma
Inactive Indication
Advanced Malignant Solid NeoplasmGlioblastoma MultiformeRecurrent Glioblastoma
Originator Organization
Ligand Pharmaceuticals, Inc.Ligand Pharmaceuticals, Inc.
Active Organization
Ligand Pharmaceuticals, Inc.Ligand Pharmaceuticals, Inc.
Inactive Organization
Proximagen Group Ltd.
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC24H34N6O
InChIKeyXNUNVQKARNSSEO-UHFFFAOYSA-N
CAS Registry1373268-67-7

Related

2
Clinical Trials associated with USL-311
EUCTR2015-004214-14-ES
/ Not yet recruitingPhase 1/2
A Phase 1/2 Dose-escalation of USL311 as Single Agent and in Combination with Lomustine (CCNU) in Subjects with Advanced Solid Tumors, with Subsequent Single Agent and Combination Phase 2 Cohorts for Subjects with Relapsed/Recurrent Glioblastoma Multiforme (GBM).
NCT02765165
/ TerminatedPhase 1/2
A Phase 1/2 Dose-escalation of USL311 as Single Agent and in Combination With Lomustine (CCNU) in Subjects With Advanced Solid Tumors, With Subsequent Single Agent and Combination Phase 2 Cohorts for Subjects With Relapsed/Recurrent Glioblastoma Multiforme (GBM)
100 Clinical Results associated with USL-311
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100 Translational Medicine associated with USL-311
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100 Patents (Medical) associated with USL-311
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100 Deals associated with USL-311
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External Link

KEGGWikiATCDrug Bank
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DB15265

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlioblastomaPhase 2-
Ligand Pharmaceuticals, Inc.Ligand Pharmaceuticals, Inc.
-
Advanced Malignant Solid NeoplasmPreclinical
United States
Proximagen Group Ltd.
01 Apr 2016
Advanced Malignant Solid NeoplasmPreclinical
Spain
Proximagen Group Ltd.
01 Apr 2016
Glioblastoma MultiformePreclinical
United States
Proximagen Group Ltd.
01 Apr 2016
Glioblastoma MultiformePreclinical
Spain
Proximagen Group Ltd.
01 Apr 2016
Recurrent GlioblastomaPreclinical
Spain
Proximagen Group Ltd.
01 Apr 2016
Recurrent GlioblastomaPreclinical
United States
Proximagen Group Ltd.
01 Apr 2016
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Clinical Result

Indication
Phase
Evaluation
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Clinical Trial

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Approval

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Regulation

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