Last update 06 Dec 2025

JTE-451

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
JTE 451
Target
RORG
Action
antagonists
Mechanism
RORG antagonists(Nuclear receptor ROR-gamma antagonists)
Therapeutic Areas
Immune System DiseasesSkin and Musculoskeletal Diseases
Active Indication-
Inactive Indication
Plaque psoriasis
Originator Organization
Japan Tobacco (Hong Kong) Ltd.
Active Organization-
Inactive Organization
Akros Pharma, Inc.
License Organization-
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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Related

4
Clinical Trials associated with JTE-451
JPRN-jRCT2031210232
/ CompletedPhase 2IIT
Phase 2a Clinical Study to evaluate efficacy and safety of JTE-451 ointment in patients with plaque psoriasis.
JPRN-jRCT2080225252
/ CompletedPhase 1
Phase 1 Clinical Study of JTE-451 ointment -Single and Multiple Dose Study-
NCT03832738
/ CompletedPhase 2
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of JTE-451 Administered for 16 Weeks in Subjects With Moderate to Severe Plaque Psoriasis (IMPACT-PS)
100 Clinical Results associated with JTE-451
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100 Translational Medicine associated with JTE-451
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100 Patents (Medical) associated with JTE-451
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100 Deals associated with JTE-451
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Plaque psoriasisPhase 2
United States
Akros Pharma, Inc.
17 Jan 2019
Plaque psoriasisPhase 2
Canada
Akros Pharma, Inc.
17 Jan 2019
Plaque psoriasisPhase 2
Poland
Akros Pharma, Inc.
17 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03832738 (IMPACT-PS, CTgov)
Phase 2
Plaque psoriasis
152
(JTE-451 200 mg Twice Daily)
qnxpmsulgm = zhogonwejc jzcimfvylk (qxfwwzkqxh, ansjgfhfib - sbdoupnbgm)
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-
16 Aug 2021
(JTE-451 400 mg Twice Daily)
qnxpmsulgm = ugjgdreqhx jzcimfvylk (qxfwwzkqxh, ezxyewgbhm - ommuzgpmxn)
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Clinical Trial

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Approval

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Regulation

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